David Ish‐Horowicz
YOU?
Author Swipe
View article: A second genetic screen for <i>gurken</i> mRNA mislocalisation uncovers novel phenotypes of piRNA pathway mutants in <i>Drosophila</i>
A second genetic screen for <i>gurken</i> mRNA mislocalisation uncovers novel phenotypes of piRNA pathway mutants in <i>Drosophila</i> Open
Transposon silencing is essential for germline development. In Drosophila oogenesis, DNA damage caused by transposon activation affects microtubule-dependent mRNA localisation in the oocyte and impairs embryonic axes formation. Our previou…
View article: Dynamically regulated transcription factors are encoded by highly unstable mRNAs in the <i>Drosophila</i> larval brain
Dynamically regulated transcription factors are encoded by highly unstable mRNAs in the <i>Drosophila</i> larval brain Open
The level of each RNA species depends on the balance between its rates of production and decay. Although previous studies have measured RNA decay across the genome in tissue culture and single-celled organisms, few experiments have been pe…
View article: Dynamically regulated transcription factors are encoded by highly unstable mRNAs in the<i>Drosophila</i>larval brain
Dynamically regulated transcription factors are encoded by highly unstable mRNAs in the<i>Drosophila</i>larval brain Open
The level of each RNA species depends on the balance between its rates of production and decay. Although previous studies have measured RNA decay across the genome in tissue culture and single-celled organisms, few experiments have been pe…
View article: Syncrip/hnRNP Q is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation
Syncrip/hnRNP Q is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation Open
Memory and learning involve activity-driven expression of proteins and cytoskeletal reorganization at new synapses, requiring posttranscriptional regulation of localized mRNA a long distance from corresponding nuclei. A key factor expresse…
View article: Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability
Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability Open
The numerous neurons and glia that form the brain originate from tightly controlled growth and division of neural stem cells, regulated systemically by important known stem cell-extrinsic signals. However, the cell-intrinsic mechanisms tha…
View article: <i>Greb1</i> is required for axial elongation and segmentation in vertebrate embryos
<i>Greb1</i> is required for axial elongation and segmentation in vertebrate embryos Open
During vertebrate embryonic development, the formation of axial structures is driven by a population of stem-like cells that reside in a region of the tailbud called the chordoneural hinge (CNH). We have compared the mouse CNH transcriptom…
View article: Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation
Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation Open
During Drosophila and vertebrate brain development, the conserved transcription factor Prospero/Prox1 is an important regulator of the transition between proliferation and differentiation. Prospero level is low in neural stem cells and the…
View article: Author response: Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability
Author response: Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The numerous neurons and glia…
View article: Imp/IGF2BP levels modulate individual neural stem cell growth and division through <i>myc</i> mRNA stability
Imp/IGF2BP levels modulate individual neural stem cell growth and division through <i>myc</i> mRNA stability Open
The numerous neurons and glia that form the brain originate from tightly controlled growth and division of neural stem cells, regulated systemically by known extrinsic signals. However, the intrinsic mechanisms that control the characteris…
View article: <i>Greb1</i>is required for axial elongation and segmentation in vertebrate embryos
<i>Greb1</i>is required for axial elongation and segmentation in vertebrate embryos Open
During vertebrate embryonic development, the formation of axial structures is driven by a population of stem-like cells that reside in a region of the tailbud called the chordoneural hinge (CNH). We have compared the CNH transcriptome with…
View article: Syncrip/hnRNPQ is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation
Syncrip/hnRNPQ is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation Open
Memory and learning involve activity-driven expression of proteins and cytoskeletal reorganisation at new synapses, often requiring post-transcriptional regulation a long distance from corresponding nuclei. A key factor expressed early in …
View article: Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation
Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation Open
During Drosophila and vertebrate brain development, the conserved transcription factor Prospero/Prox1 is an important regulator of the transition between proliferation and differentiation. Prospero level is low in neural stem cells and the…
View article: Imp/Syp temporal gradients govern decommissioning of<i>Drosophila</i>neural stem cells
Imp/Syp temporal gradients govern decommissioning of<i>Drosophila</i>neural stem cells Open
Timing of Drosophila neuroblast decommissioning is controlled in a lineage-specific manner. Following a prepupal ecdysone pulse, the ecdysone receptor and mediator complex cause neuroblasts to shrink. Shrinking is followed by nuclear accum…
View article: Single molecule fluorescence<i>in situ</i>hybridisation for quantitating post-transcriptional regulation in<i>Drosophila</i>brains
Single molecule fluorescence<i>in situ</i>hybridisation for quantitating post-transcriptional regulation in<i>Drosophila</i>brains Open
RNA in situ hybridization can be a powerful method to investigate post-transcriptional regulation, but analysis of intracellular mRNA distributions in thick, complex tissues like the brain poses significant challenges. Here, we describe th…
View article: Imp and Syp RNA-binding proteins govern decommissioning of <i>Drosophila</i> neural stem cells
Imp and Syp RNA-binding proteins govern decommissioning of <i>Drosophila</i> neural stem cells Open
The termination of the proliferation of Drosophila neural stem cells, also known as neuroblasts (NBs), requires a “decommissioning” phase that is controlled in a lineage-specific manner. Most NBs, with the exception of those of the Mushroo…