David J. Barlow
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View article: Intermittent upwelling impacts zooplankton and their gray whale predators at multiple scales
Intermittent upwelling impacts zooplankton and their gray whale predators at multiple scales Open
Coastal upwelling dynamics influence the abundance and distribution of marine zooplankton; however, knowledge of how intermittent upwelling patterns impact nearshore prey retention and predator foraging is limited. The Pacific Coast Feedin…
View article: Rendering the European Neutron Research Landscape
Rendering the European Neutron Research Landscape Open
Neutrons, owing to their unique properties, serve as indispensable probes for investigating the structure and dynamics of materials across various length scales. The scientific community utilizing neutron research infrastructures encompass…
View article: Characterisation of the apparent aqueous solubility enhancement of testosterone analogues in micelles of dodecyl-chained surfactants with different headgroups
Characterisation of the apparent aqueous solubility enhancement of testosterone analogues in micelles of dodecyl-chained surfactants with different headgroups Open
The solubilisation capacities of the micelles formed by a range of surfactants possessing a dodecyl (C12) hydrocarbon ‘tail’ and a variety of hydrophilic ‘headgroups’ have been studied for a range of hydrophobic steroids (testosterone (T) …
View article: Understanding and optimising the transfection of lipopolyplexes formulated in saline: the effects of peptide and serum
Understanding and optimising the transfection of lipopolyplexes formulated in saline: the effects of peptide and serum Open
Lipopolyplexes formulated from branched cationic peptides with cell receptor targeting sequences, DOTMA and DOPE, and plasmid DNA in the presence of saline form multilamellar nanoparticles with enhanced stability and transfection in serum.
View article: On the interactions of diols and DMPC monolayers
On the interactions of diols and DMPC monolayers Open
The interactions of lipid molecules with various solvent molecules is of utmost importance in the formulation of various drug delivery and personal care formulations. In this manuscript, a series of all-atom molecular dynamics simulations …
View article: Nanoscale Structure and Dynamics of Model Membrane Lipid Raft Systems, Studied by Neutron Scattering Methods
Nanoscale Structure and Dynamics of Model Membrane Lipid Raft Systems, Studied by Neutron Scattering Methods Open
Quasi-elastic neutron scattering (QENS) and small angle neutron scattering (SANS), in combination with isotopic contrast variation, have been used to determine the structure and dynamics of three-component lipid membranes, in the form of v…
View article: NSAID solubilisation promotes morphological transitions in Triton X-114 surfactant micelles
NSAID solubilisation promotes morphological transitions in Triton X-114 surfactant micelles Open
The structural properties of micelles formed by the non-ionic surfactant, Triton X-114 (TX-114), were investigated using all-atom molecular dynamics (MD) simulations. Additionally, we investigated the effect of the solubilisation of the so…
View article: The importance of ceramide headgroup for lipid localisation in skin lipid models
The importance of ceramide headgroup for lipid localisation in skin lipid models Open
The stratum corneum's lipid matrix is a critical for the skin's barrier function and is primarily composed of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs). The lipids form a long periodicity phase (LPP), a unique trilay…
View article: Impact of drug aggregation on the structural and dynamic properties of Triton X-100 micelles
Impact of drug aggregation on the structural and dynamic properties of Triton X-100 micelles Open
We provide molecular scale detail of how the aggregation of drug molecules within a surfactant micelle can destabilise the micelle.
View article: Stability of α-lactose monohydrate: The discovery of dehydration triggered solid-state epimerization
Stability of α-lactose monohydrate: The discovery of dehydration triggered solid-state epimerization Open
Lactose is present as an excipient in nearly half of all solid medicines. Despite the assumption of chemical stability, in aqueous solution, the chiral composition of lactose is prone to change. It is not known whether such epimerisation c…
View article: The Impact of Lipid Digestion on the Dynamic and Structural Properties of Micelles
The Impact of Lipid Digestion on the Dynamic and Structural Properties of Micelles Open
Self‐assembled, lipid‐based micelles, such as those formed by the short‐chain phosphocholine, dihexanoylphosphatidylcholine (2C6PC), are degraded by the pancreatic enzyme, phospholipase A 2 (PLA2). Degradation yields 1‐hexanoyl‐lysophospho…
View article: A Cyclodextrin‐Stabilized Spermine‐Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency
A Cyclodextrin‐Stabilized Spermine‐Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency Open
Ion‐pairing a lifesaving drug such as theophylline with a targeting moiety could have a significant impact on medical emergencies such as status asthmaticus or COVID‐19 induced pneumomediastinum. However, to achieve rapid drug targeting in…
View article: The Influence of Co-Surfactants on Lamellar Liquid Crystal Structures Formed in Creams
The Influence of Co-Surfactants on Lamellar Liquid Crystal Structures Formed in Creams Open
It is well-established that oil-in-water creams can be stabilised through the formation of lamellar liquid crystal structures in the continuous phase, achieved by adding (emulsifier) mixtures comprising surfactant(s) combined (of necessity…
View article: Arrangement of Ceramides in the Skin: Sphingosine Chains Localize at a Single Position in Stratum Corneum Lipid Matrix Models
Arrangement of Ceramides in the Skin: Sphingosine Chains Localize at a Single Position in Stratum Corneum Lipid Matrix Models Open
Understanding the structure of the stratum corneum (SC) is essential to understand the skin barrier process. The long periodicity phase (LPP) is a unique trilayer lamellar structure located in the SC. Adjustments in the composition of the …
View article: Revealing the Hidden Details of Nanostructure in a Pharmaceutical Cream
Revealing the Hidden Details of Nanostructure in a Pharmaceutical Cream Open
Creams are multi-component semi-solid emulsions that find widespread utility across a wide range of pharmaceutical, cosmetic, and personal care products, and they also feature prominently in veterinary preparations and processed foodstuffs…
View article: Using Polar Ion-Pairs to Control Drug Delivery to the Airways of the Lungs
Using Polar Ion-Pairs to Control Drug Delivery to the Airways of the Lungs Open
The rapid absorptive clearance of drugs delivered to the airways of the lungs means that many inhaled medicines have a short duration of action. The aim of this study was to investigate whether forming polar ion-pairs can modify drug absor…
View article: Nicotinamide <i>N</i>-Methyltransferase: Genomic Connection to Disease
Nicotinamide <i>N</i>-Methyltransferase: Genomic Connection to Disease Open
Single-nucleotide polymorphisms (SNPs) in and around the nicotinamide N-methyltransferase (NNMT) gene are associated with a range of cancers and other diseases and conditions. The data on these associations have been assembled, and their s…
View article: Design, Synthesis and Discovery of <i>N,N’</i>‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication
Design, Synthesis and Discovery of <i>N,N’</i>‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication Open
The recent outbreaks of Zika virus (ZIKV) infection worldwide make the discovery of novel antivirals against flaviviruses a research priority. This work describes the identification of novel inhibitors of ZIKV through a structure‐based vir…
View article: Dataset for "Assessing molecular simulation for the analysis of lipid monolayer reflectometry"
Dataset for "Assessing molecular simulation for the analysis of lipid monolayer reflectometry" Open
Reduced neutron reflectometry dataset associated with a contrast series of DSPC (distearoyl phosphatidylcholine) at the air-water interface. Molecular dynamics simulations at four different areas per molecule are included for three differe…
View article: Status of the UCN<b>τ</b> experiment
Status of the UCN<b>τ</b> experiment Open
The neutron is the simplest nuclear system that can be used to probe the structure of the weak interaction and search for physics beyond the standard model. Measurements of neutron lifetime and β-decay correlation coefficients with precisi…
View article: The discovery and enhanced properties of trichain lipids in lipopolyplex gene delivery systems
The discovery and enhanced properties of trichain lipids in lipopolyplex gene delivery systems Open
Novel trichain lipids have been identified with enhanced transfection properties in lipopolyplexes.
View article: Trichain cationic lipids: the potential of their lipoplexes for gene delivery
Trichain cationic lipids: the potential of their lipoplexes for gene delivery Open
Lipoplexes (LDs) have been prepared from DNA, DOPE and either a dichain oxyethylated cationic lipid or their novel trichain (TC) counterpart.
View article: The mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding
The mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding Open
Mycosporine-like amino acids (MAAs) are UVR-absorbing metabolites typically produced by cyanobacteria and marine algae, but their properties are not limited to direct sun screening protection. Herein, we examine the antioxidant activities …
View article: Application of machine learning in prediction of hydrotrope-enhanced solubilisation of indomethacin
Application of machine learning in prediction of hydrotrope-enhanced solubilisation of indomethacin Open
Systematic in-vitro studies have been conducted to determine the ability of a range of 10 potential hydrotropes to improve the apparent aqueous solubility of the poorly water soluble drug, indomethacin. Solubilisation of the drug in the pr…