David Clarke
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View article: A haplotype-resolved, chromosome-scale genome assembly for the southern live oak, <i>Quercus virginiana</i>
A haplotype-resolved, chromosome-scale genome assembly for the southern live oak, <i>Quercus virginiana</i> Open
Hybridization is a major force driving diversification, migration, and adaptation in Quercus species. While population genetics and phylogenetics have traditionally been used for studying these processes, advances in sequencing technology …
View article: Size and chemistry of 1–2 layer graphene nanosheets at the transition into photoluminescence and assembly with large shifts from blue to red emission
Size and chemistry of 1–2 layer graphene nanosheets at the transition into photoluminescence and assembly with large shifts from blue to red emission Open
View article: Engineering supramolecular dynamics of self-assembly and turnover of oncogenic microRNAs to drive their synergistic destruction in tumor models
Engineering supramolecular dynamics of self-assembly and turnover of oncogenic microRNAs to drive their synergistic destruction in tumor models Open
Rationally-engineered functional biomaterials offer the opportunity to interface with complex biology in a predictive, precise, yet dynamic way to reprogram their behaviour and correct shortcomings. Success here may lead to a desired thera…
View article: Bulge-Forming miRNases Cleave Oncogenic miRNAs at the Central Loop Region in a Sequence-Specific Manner
Bulge-Forming miRNases Cleave Oncogenic miRNAs at the Central Loop Region in a Sequence-Specific Manner Open
The selective degradation of disease-associated microRNA is promising for the development of new therapeutic approaches. In this study, we engineered a series of bulge-loop-forming oligonucleotides conjugated with catalytic peptide [(LeuAr…
View article: Establishing the Socio-Economic Impact of Degenerative Cervical Myelopathy Is Fundamental to Improving Outcomes [AO Spine RECODE-DCM Research Priority Number 8]
Establishing the Socio-Economic Impact of Degenerative Cervical Myelopathy Is Fundamental to Improving Outcomes [AO Spine RECODE-DCM Research Priority Number 8] Open
Study Design: Literature Review (Narrative). Objective: To contextualize AO Spine RECODE-DCM research priority number 5: What is the socio-economic impact of DCM? (The financial impact of living with DCM to the individual, their supporters…
View article: "Bind, cleave and leave": multiple turnover catalysis of RNA cleavage by bulge-loop inducing supramolecular conjugates.
"Bind, cleave and leave": multiple turnover catalysis of RNA cleavage by bulge-loop inducing supramolecular conjugates. Open
Antisense sequence-specific knockdown of pathogenic RNA offers opportunities to find new solutions for therapeutic treatments. However, to gain a desired therapeutic effect, the multiple turnover catalysis is critical to inactivate many co…
View article: “Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates
“Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates Open
Antisense sequence-specific knockdown of pathogenic RNA offers opportunities to find new solutions for therapeutic treatments. However, to gain a desired therapeutic effect, the multiple turnover catalysis is critical to inactivate many co…
View article: A ribosomally synthesized and post-translationally modified peptide containing a β-amino acid and a macrocyclic motif
A ribosomally synthesized and post-translationally modified peptide containing a β-amino acid and a macrocyclic motif Open
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are structurally complex naturally occurring metabolites across all three domains of life. Despite the structural diversity of RiPPs that stems from the extensive p…
View article: Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates
Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates Open
Potent knockdown of pathogenic RNA in vivo is an urgent health need unmet by both small-molecule and biologic drugs. ‘Smart’ supramolecular assembly of catalysts offers precise recognition and potent destruction of targeted RNA, hitherto n…
View article: Buying what people like you buy: Personality Homophily and Well-being in Consumer Behaviour
Buying what people like you buy: Personality Homophily and Well-being in Consumer Behaviour Open
Recommender systems and personalised marketing algorithms now proliferate our daily lives, harnessing similarity to other profiles to guide our purchasing decisions. Recent research indicates that this personalisation can be good for our w…
View article: RNA knockdown by synthetic peptidyl-oligonucleotide ribonucleases: behavior of recognition and cleavage elements under physiological conditions
RNA knockdown by synthetic peptidyl-oligonucleotide ribonucleases: behavior of recognition and cleavage elements under physiological conditions Open
Sequence-specific protein-based ribonucleases are not found in nature. Absolute sequence selectivity in RNA cleavage in vivo normally requires multi-component complexes that recruit a guide RNA or DNA for target recognition a…
View article: Dissecting the structural and functional roles of a vicinal iron-binding site in encapsulated ferritins
Dissecting the structural and functional roles of a vicinal iron-binding site in encapsulated ferritins Open
Encapsulated ferritins belong to the universally distributed ferritin superfamily, which function as iron detoxification and storage systems. Encapsulated ferritins have a distinct annular structure and must associate with an encapsulin na…
View article: Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model
Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model Open
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonu…
View article: Sequence-Specific Detection of Unlabeled Nucleic Acid Biomarkers Using a “One-Pot” 3D Molecular Sensor
Sequence-Specific Detection of Unlabeled Nucleic Acid Biomarkers Using a “One-Pot” 3D Molecular Sensor Open
DNA and RNA biomarkers have not progressed beyond the automated specialized clinic due to failure in the reproducibility necessary to standardize robust and rapid nucleic acid detection at the point of care, where health outcomes can be mo…
View article: Notes on Contributors
Notes on Contributors Open
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View article: NMR detects molecular interactions of graphene with aromatic and aliphatic hydrocarbons in water
NMR detects molecular interactions of graphene with aromatic and aliphatic hydrocarbons in water Open
Polyaromatic carbon is widely held to be strongly diamagnetic and hydrophobic, with textbook van der Waals and 'π-stacked' binding of hydrocarbons, which disrupt their self-assembled supramolecular structures. The NMR of organic molecules …
View article: Sulfide concentrations as a function of time from INSPIRE track 1 collected from 2013 to 2017 (INSPIRE Pyrite project)
Sulfide concentrations as a function of time from INSPIRE track 1 collected from 2013 to 2017 (INSPIRE Pyrite project) Open
track 1 collected from 2013 to 2017 (INSPIRE Pyrite project)
View article: Dispersal of pristine graphene for biological studies
Dispersal of pristine graphene for biological studies Open
Herein, we address the conflicting behaviour of different pristine graphene dispersions through their careful preparation and characterization in aqueous media.
View article: Author Index
Author Index Open
View article: Author Index
Author Index Open