David J. Crossman
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View article: Sex differences in ventricular muscle energetics in a type 2 diabetic rat model
Sex differences in ventricular muscle energetics in a type 2 diabetic rat model Open
Effects of type 2 diabetes do not manifest in the mechanoenergetic functional performance of isolated cardiac muscles, even when challenged to a wide range of loading conditions. This conclusion is upheld in both male and female rats. Thes…
View article: Sex differences in cardiac energetics in type 2 diabetic rat ventricular muscle
Sex differences in cardiac energetics in type 2 diabetic rat ventricular muscle Open
Background: Sex differences in cardiac function under diabetic conditions have been extensively studied. However, the impacts of type 2 diabetes on cardiac energetics between sexes remain poorly defined. Likewise, whether sex-specific diff…
View article: Reverse remodelling of the mitochondria and cytoskeleton after respiratory heart rate variability pacing of the failing sheep heart
Reverse remodelling of the mitochondria and cytoskeleton after respiratory heart rate variability pacing of the failing sheep heart Open
We have previously demonstrated that pacing the failing sheep heart with respiratory heart rate variability (RespHRV), a natural variability in the heart rate that is linked to respiration on a breath-by-breath basis, improves cardiac outp…
View article: ReefCloud: Harnessing AI for integrated coral reef monitoring and agile conservation
ReefCloud: Harnessing AI for integrated coral reef monitoring and agile conservation Open
Coral reefs, vital to marine biodiversity and the livelihoods of about a billion people worldwide, face unprecedented threats from climate change, pollution, and overfishing. Effective and timely conservation strategies guided by status an…
View article: The absence of collagen VI reduces systolic function but paradoxically increases Ca<sup>2+</sup>release in the rat heart
The absence of collagen VI reduces systolic function but paradoxically increases Ca<sup>2+</sup>release in the rat heart Open
Collagen VI has recently been strongly linked to poor outcomes in heart failure with preserved ejection fraction through increased endotrophin, a collagen VI-derived signalling molecule linked to fibrotic remodelling in cardiovascular dise…
View article: Sex differences in cardiac energetics in the rat ventricular muscle
Sex differences in cardiac energetics in the rat ventricular muscle Open
Cardiac sex-difference functional studies have centred on measurements of twitch force and Ca2+ dynamics. The energy expenditures from these two cellular processes: activation (Ca2+ handling) and contraction (cross-bridge cycling), have no…
View article: Pirfenidone increases transverse tubule length in the infarcted rat myocardium
Pirfenidone increases transverse tubule length in the infarcted rat myocardium Open
Transverse (t)-tubule remodelling is a prominent feature of heart failure with reduced ejection fraction (HFrEF). In our previous research, we identified an increased amount of collagen within the t-tubules of HFrEF patients, suggesting fi…
View article: Reverse re-modelling chronic heart failure by reinstating heart rate variability
Reverse re-modelling chronic heart failure by reinstating heart rate variability Open
Heart rate variability (HRV) is a crucial indicator of cardiovascular health. Low HRV is correlated with disease severity and mortality in heart failure. Heart rate increases and decreases with each breath in normal physiology termed respi…
View article: Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart
Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart Open
The disrupted organisation of the ryanodine receptors (RyR) and junctophilin (JPH) is thought to underpin the transverse tubule (t-tubule) remodelling in a failing heart. Here, we assessed the nanoscale organisation of these two key protei…
View article: Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function
Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function Open
Increased heart size is a major risk factor for heart failure and premature mortality. Although abnormal heart growth subsequent to hypertension often accompanies disturbances in mechano-energetics and cardiac efficiency, it remains uncert…
View article: Shining New Light on the Structural Determinants of Cardiac Couplon Function: Insights From Ten Years of Nanoscale Microscopy
Shining New Light on the Structural Determinants of Cardiac Couplon Function: Insights From Ten Years of Nanoscale Microscopy Open
Remodelling of the membranes and protein clustering patterns during the pathogenesis of cardiomyopathies has renewed the interest in spatial visualisation of these structures in cardiomyocytes. Coincidental emergence of single molecule (su…
View article: Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive—A New Preclinical Model
Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive—A New Preclinical Model Open
Background Among the growing numbers of patients with heart failure, up to one half have heart failure with preserved ejection fraction ( HF p EF ). The lack of effective treatments for HF p EF is a substantial and escalating unmet clinica…
View article: Transverse tubule remodelling: a cellular pathology driven by both sides of the plasmalemma?
Transverse tubule remodelling: a cellular pathology driven by both sides of the plasmalemma? Open
Transverse (t)-tubules are invaginations of the plasma membrane that form a complex network of ducts, 200-400 nm in diameter depending on the animal species, that penetrates deep within the cardiac myocyte, where they facilitate a fast and…
View article: High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice
High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice Open
Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized by progressive weakening and dilatation of the aortic wall. Thrombospondin-1 (TSP-1; gene Thbs1) is a member of the matricellular protein family importa…
View article: Increased collagen within the transverse tubules in human heart failure
Increased collagen within the transverse tubules in human heart failure Open
Increased expression and labelling of collagen in IDCM samples indicates fibrosis may contribute to t-tubule remodelling in human heart failure.
View article: Impaired ADP channeling to mitochondria and elevated reactive oxygen species in hypertensive hearts
Impaired ADP channeling to mitochondria and elevated reactive oxygen species in hypertensive hearts Open
Systemic hypertension initially promotes a compensatory cardiac hypertrophy, yet it progresses to heart failure (HF), and energetic deficits appear to be central to this failure. However, the transfer of energy between the mitochondria and…
View article: Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes
Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes Open
Spatio-temporal dynamics of intracellular calcium, [Ca2+]i, regulate the contractile function of cardiac muscle cells. Measuring [Ca2+]i flux is central to the study of mechanisms that underlie both normal cardiac function and calcium-depe…