David J. Culp
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View article: Cariogenic potential of the <i>Streptococcus mutans</i> Cid/Lrg system: an <i>in vivo</i> animal case study
Cariogenic potential of the <i>Streptococcus mutans</i> Cid/Lrg system: an <i>in vivo</i> animal case study Open
In our prior study using a dual-species ( Streptococcus mutans/Streptococcus gordonii ) competitive mouse caries model to investigate the contribution of S. mutans LrgAB to in vivo fitness, S. mutans wild-type and Δ lrgAB mutants consisten…
View article: Testing of candidate probiotics to prevent dental caries induced by Streptococcus mutans in a mouse model
Testing of candidate probiotics to prevent dental caries induced by Streptococcus mutans in a mouse model Open
Aims We evaluated two species of human oral commensal streptococci in protection against dental caries induced by Streptococcus mutans. Methods and Results Candidate probiotics, Streptococcus sp. A12, Streptococcus sanguinis BCC23 and an a…
View article: Murine Salivary Amylase Protects Against Streptococcus mutans-Induced Caries
Murine Salivary Amylase Protects Against Streptococcus mutans-Induced Caries Open
Saliva protects dental surfaces against cavities (i. e., dental caries), a highly prevalent infectious disease frequently associated with acidogenic Streptococcus mutans . Substantial in vitro evidence supports amylase, a major constituent…
View article: Manganese transport by <i>Streptococcus sanguinis</i> in acidic conditions and its impact on growth <i>in vitro</i> and <i>in vivo</i>
Manganese transport by <i>Streptococcus sanguinis</i> in acidic conditions and its impact on growth <i>in vitro</i> and <i>in vivo</i> Open
Summary Streptococcus sanguinis is an oral commensal and an etiological agent of infective endocarditis. Previous studies have identified the SsaACB manganese transporter as essential for endocarditis virulence; however, the significance o…
View article: <i>In Vivo</i> Colonization with Candidate Oral Probiotics Attenuates Streptococcus mutans Colonization and Virulence
<i>In Vivo</i> Colonization with Candidate Oral Probiotics Attenuates Streptococcus mutans Colonization and Virulence Open
Our results demonstrate that in vivo testing of potential oral probiotics can be accomplished and can yield information to facilitate the ultimate design and optimization of novel anticaries probiotics. We show that human oral commensals a…
View article: Understanding LrgAB Regulation of Streptococcus mutans Metabolism
Understanding LrgAB Regulation of Streptococcus mutans Metabolism Open
Lack of LrgAB renders cariogenic Streptococcus mutans more sensitive to oxidative stress, as well as limits the capacity of this organism to re-uptake pyruvate upon starvation. This study was aimed at investigating the ecological and metab…
View article: Genomewide Identification of Essential Genes and Fitness Determinants of Streptococcus mutans UA159
Genomewide Identification of Essential Genes and Fitness Determinants of Streptococcus mutans UA159 Open
Tooth decay (dental caries) is a common cause of pain, impaired quality of life, and tooth loss in children and adults. It begins because of a compositional change in the microorganisms that colonize the tooth surface driven by repeated an…
View article: Mrs. Crawford Is Too Sweet for Her Own Good! A Problem-Based Learning Exercise for Dental Students
Mrs. Crawford Is Too Sweet for Her Own Good! A Problem-Based Learning Exercise for Dental Students Open
Introduction This problem-based learning (PBL) exercise is designed for third-year dental students and covers the management of a partially edentulous patient with diabetes, periodontal disease, and financial constraints. This exercise pro…