David J. Feifarek
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View article: Evaluation of the endocrine disrupting potential of Di-isononyl phthalate
Evaluation of the endocrine disrupting potential of Di-isononyl phthalate Open
Low molecular weight ortho-phthalate compounds have been implicated in disruption of androgen pathways when exposure occurs during the masculinization programming window. Di-isononyl phthalate (DINP) is a high molecular weight phtha…
View article: Evaluation of the endocrine disrupting potential of Di-isodecyl phthalate
Evaluation of the endocrine disrupting potential of Di-isodecyl phthalate Open
View article: Corrigendum to “Evaluation of the Endocrine Disrupting Potential of Di-isononyl Phthalate” [Curr. Res. Toxicol. 8 (2025) 100220]
Corrigendum to “Evaluation of the Endocrine Disrupting Potential of Di-isononyl Phthalate” [Curr. Res. Toxicol. 8 (2025) 100220] Open
View article: Evaluation of Complex Mixture Toxicity in the Milwaukee Estuary (WI, USA) Using Whole-Mixture and Component-Based Evaluation Methods
Evaluation of Complex Mixture Toxicity in the Milwaukee Estuary (WI, USA) Using Whole-Mixture and Component-Based Evaluation Methods Open
Anthropogenic activities introduce complex mixtures into aquatic environments, necessitating mixture toxicity evaluation during risk assessment. There are many alternative approaches that can be used to complement traditional techniques fo…
View article: Case Study in 21st-Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Reproductive Outcomes in Fish In Vivo
Case Study in 21st-Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Reproductive Outcomes in Fish In Vivo Open
To reduce the use of intact animals for chemical safety testing, while ensuring protection of ecosystems and human health, there is a demand for new approach methodologies (NAMs) that provide relevant scientific information at a quality eq…
View article: Male fathead minnow transcriptomes and associated chemical analytes in the Milwaukee estuary system
Male fathead minnow transcriptomes and associated chemical analytes in the Milwaukee estuary system Open
View article: dynamic query
dynamic query Open
dynamic query of the chemistry database complete data set
View article: water quality data
water quality data Open
Complete USGS water quality data
View article: Water quality data
Water quality data Open
Complete USGS water quality data
View article: <i>ET&C</i> Best Paper of 2020
<i>ET&C</i> Best Paper of 2020 Open
For pesticide registration, terrestrial ecotoxicity testing mainly focuses on assessing the effects of chemicals on organisms living in the soil (e.g., earthworms, springtails, microorganisms) and on above-ground nontarget arthropods (e.g.…
View article: Case Study in 21st Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Short-Term In Vivo Responses in Adult Female Fish
Case Study in 21st Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Short-Term In Vivo Responses in Adult Female Fish Open
The present study evaluated whether in vitro measures of aromatase inhibition as inputs into a quantitative adverse outcome pathway (qAOP) construct could effectively predict in vivo effects on 17β-estradiol (E2) and vitellogenin (VTG) con…
View article: Pathway-Based Approaches for Assessing Biological Hazards of Complex Mixtures of Contaminants: A Case Study in the Maumee River
Pathway-Based Approaches for Assessing Biological Hazards of Complex Mixtures of Contaminants: A Case Study in the Maumee River Open
Assessment of ecological risks of chemicals in the field usually involves complex mixtures of known and unknown compounds. We describe the use of pathway-based chemical and biological approaches to assess the risk of chemical mixtures in t…
View article: Comparison of Machine Learning Models for the Androgen Receptor
Comparison of Machine Learning Models for the Androgen Receptor Open
The androgen receptor (AR) is a target of interest for endocrine disruption research, as altered signaling can affect normal reproductive and neurological development for generations. In an effort to prioritize compounds with alternative m…
View article: Water Chemistry Profiles of Milwaukee Estuary System Sites
Water Chemistry Profiles of Milwaukee Estuary System Sites Open
Contaminants of Emerging Concern (CECs) can be measured in waters across the United States, including the tributaries of the Great Lakes. The extent to which these contaminants affect gene expression in aquatic wildlife is unclear. This da…
View article: Water Chemistry Profiles of Milwaukee Estuary System Sites
Water Chemistry Profiles of Milwaukee Estuary System Sites Open
Contaminants of Emerging Concern (CECs) can be measured in waters across the United States, including the tributaries of the Great Lakes. The extent to which these contaminants affect gene expression in aquatic wildlife is unclear. This da…
View article: Adverse Outcome Pathway Network–Based Assessment of the Interactive Effects of an Androgen Receptor Agonist and an Aromatase Inhibitor on Fish Endocrine Function
Adverse Outcome Pathway Network–Based Assessment of the Interactive Effects of an Androgen Receptor Agonist and an Aromatase Inhibitor on Fish Endocrine Function Open
Predictive approaches to assessing the toxicity of contaminant mixtures have been largely limited to chemicals that exert effects through the same biological molecular initiating event. However, by understanding specific pathways through w…
View article: Effects–Based Monitoring Under the Great Lakes Restoration Initiative: Evaluation of Spatial and Temporal Patterns in the Milwaukee Estuary
Effects–Based Monitoring Under the Great Lakes Restoration Initiative: Evaluation of Spatial and Temporal Patterns in the Milwaukee Estuary Open
Poster presentation to the SETAC North America annual meeting November 2020
View article: Re-evaluating the Significance of Estrone as an Environmental Estrogen
Re-evaluating the Significance of Estrone as an Environmental Estrogen Open
Studies worldwide have demonstrated the occurrence of feminized male fish at sites impacted by human and animal wastes. A variety of chemicals could contribute to this phenomenon, but those receiving the greatest attention in terms of rese…