David A. Mead
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View article: Developing coral seeding devices and rapid deployment methods to scale up reef restoration
Developing coral seeding devices and rapid deployment methods to scale up reef restoration Open
Current coral restoration methods are constrained by several factors, including low survival rates and high costs of coral production and deployment, making it difficult to address ecosystem‐wide coral declines. This study introduces a new…
View article: The Sensory Shark: High-quality Morphological, Genomic and Transcriptomic Data for the Small-spotted Catshark <i>Scyliorhinus Canicula</i> Reveal the Molecular Bases of Sensory Organ Evolution in Jawed Vertebrates
The Sensory Shark: High-quality Morphological, Genomic and Transcriptomic Data for the Small-spotted Catshark <i>Scyliorhinus Canicula</i> Reveal the Molecular Bases of Sensory Organ Evolution in Jawed Vertebrates Open
Cartilaginous fishes (chondrichthyans: chimeras and elasmobranchs -sharks, skates, and rays) hold a key phylogenetic position to explore the origin and diversifications of jawed vertebrates. Here, we report and integrate reference genomic,…
View article: B-241 A Novel Approach to Develop Multiplex Loop Mediated Amplification (LAMP) Assays
B-241 A Novel Approach to Develop Multiplex Loop Mediated Amplification (LAMP) Assays Open
Background Loop mediated amplification (LAMP) technology is a sensitive, accurate and rapid method for point-of-care (POC) molecular diagnostic detection. One disadvantage is that current LAMP methods can detect only one target per reactio…
View article: Nanoscaled Discovery of a Shunt Rifamycin from <i>Salinispora arenicola</i> Using a Three-Color GFP-Tagged <i>Staphylococcus aureus</i> Macrophage Infection Assay
Nanoscaled Discovery of a Shunt Rifamycin from <i>Salinispora arenicola</i> Using a Three-Color GFP-Tagged <i>Staphylococcus aureus</i> Macrophage Infection Assay Open
Antimicrobial resistance has emerged as a global public health threat, and development of novel therapeutics for treating infections caused by multi-drug resistant bacteria is urgent. Staphylococcus aureus is a major human and animal patho…
View article: Functional biology and biotechnology of thermophilic viruses
Functional biology and biotechnology of thermophilic viruses Open
Viruses have developed sophisticated biochemical and genetic mechanisms to manipulate and exploit their hosts. Enzymes derived from viruses have been essential research tools since the first days of molecular biology. However, most viral e…
View article: A Survey of Didemnin Depsipeptide Production in Tistrella
A Survey of Didemnin Depsipeptide Production in Tistrella Open
As one of the first families of marine natural products to undergo clinical trials, the didemnin depsipeptides have played a significant role in inspiring the discovery of marine drugs. Originally developed as anticancer therapeutics, the …
View article: Table S2 Functional Biology Biotechnology of Thermophilic Viruses.xlsx
Table S2 Functional Biology Biotechnology of Thermophilic Viruses.xlsx Open
Table S2. Extended summary of protein families (Pfams) counts associated with the genes of interest found in publically available UViGs from thermal environments in the IMG/VR v4 database.
View article: Supplementary Material for Functional Biology and Biotechnology of Thermophilic Viruses Review
Supplementary Material for Functional Biology and Biotechnology of Thermophilic Viruses Review Open
Extended summary of protein families (Pfams) counts associated with the genes of interest found in UViGs from thermal environments in the IMG/VR v4 database.
View article: Supplementary Material for Functional Biology and Biotechnology of Thermophilic Viruses Review.xlsx
Supplementary Material for Functional Biology and Biotechnology of Thermophilic Viruses Review.xlsx Open
Extended summary of protein families (Pfams) counts associated with the genes of interest found in UViGs from thermal environments in the IMG/VR v4 database/
View article: Novel Viral DNA Polymerases From Metagenomes Suggest Genomic Sources of Strand-Displacing Biochemical Phenotypes
Novel Viral DNA Polymerases From Metagenomes Suggest Genomic Sources of Strand-Displacing Biochemical Phenotypes Open
Viruses are the most abundant and diverse biological entities on the planet and constitute a significant proportion of Earth’s genetic diversity. Most of this diversity is not represented by isolated viral-host systems and has only been ob…
View article: Discovery of Novel Biosynthetic Gene Cluster Diversity From a Soil Metagenomic Library
Discovery of Novel Biosynthetic Gene Cluster Diversity From a Soil Metagenomic Library Open
Soil microorganisms historically have been a rich resource for natural product discovery, yet the majority of these microbes remain uncultivated and their biosynthetic capacity is left underexplored. To identify the biosynthetic potential …
View article: Diversity and Distribution of a Novel Genus of Hyperthermophilic Aquificae Viruses Encoding a Proof-Reading Family-A DNA Polymerase
Diversity and Distribution of a Novel Genus of Hyperthermophilic Aquificae Viruses Encoding a Proof-Reading Family-A DNA Polymerase Open
Despite the high abundance of Aquificae in many geothermal systems, these bacteria are difficult to culture and no viruses infecting members of this phylum have been isolated. Here, we describe the complete, circular dsDNA Uncultivated Vir…
View article: Interventions to help coral reefs under global change—A complex decision challenge
Interventions to help coral reefs under global change—A complex decision challenge Open
Climate change is impacting coral reefs now. Recent pan-tropical bleaching events driven by unprecedented global heat waves have shifted the playing field for coral reef management and policy. While best-practice conventional management re…
View article: Cloning, Expression and Characterization of the α-glucuronidase from the Hyperthermophile DictyoglomusturgidumDSM 6724Ô
Cloning, Expression and Characterization of the α-glucuronidase from the Hyperthermophile DictyoglomusturgidumDSM 6724Ô Open
Conversion of biomass into fermentable sugars is a major requirement for successful and cost-effective biofuels production. The conversion of xylan to sugars requires multiple enzymes including α-glucuronidase. Here we report the cloning, …
View article: Diversity and Distribution of a Novel Genus of Hyperthermophilic<i>Aquificae</i>Viruses Encoding a Proof-reading Family-A DNA Polymerase
Diversity and Distribution of a Novel Genus of Hyperthermophilic<i>Aquificae</i>Viruses Encoding a Proof-reading Family-A DNA Polymerase Open
Despite the high abundance of Aquificae in many geothermal systems, these bacteria are difficult to culture and no viruses infecting members of this phylum have been isolated. Here, we describe the complete, circular dsDNA Uncultivated Vir…
View article: Trichoderma reesei (Hypocrea jecorina) Bgl1 is a Novel, Exo-Acting Glucanase and Xylanase
Trichoderma reesei (Hypocrea jecorina) Bgl1 is a Novel, Exo-Acting Glucanase and Xylanase Open
Trichoderma reeseiβ-glucosidase (Bgl1) is one of four enzymes demonstrated to act synergistically to degrade cellulose both in vitro and in vivo. Our work attempted to better understand the substrate specificity and potential biotechnologi…
View article: Immobilisation of living coral embryos and larvae
Immobilisation of living coral embryos and larvae Open
Embedding and immobilisation of living cells and microorganisms is used in a variety of research and commercial applications. Here we report the successful extended immobilisation of coral larvae in a low-gelling temperature agarose. Embry…
View article: Symposium report: Great Barrier Reef restoration symposium, 2018
Symposium report: Great Barrier Reef restoration symposium, 2018 Open
The Great Barrier Reef (GBR), located off the coast of Queensland, Australia, is a UNESCO1 World Heritage site, one of the seven natural wonders of the world and the world's largest living structure. Spanning 2300 km, it has more than 450 …
View article: Hydrolysis of Cellulose by Soluble Clostridium Thermocellum and Acidothermus Cellulolyticus Cellulases
Hydrolysis of Cellulose by Soluble Clostridium Thermocellum and Acidothermus Cellulolyticus Cellulases Open
The goal of this work was to clone, express, characterize and assemble a set of soluble thermostablecellulases capable of significantly degrading cellulose. We successfully cloned, expressed, and purified eleven Clostridium thermocellum (C…
View article: The Complete Genome Sequence of Hyperthermophile Dictyoglomus turgidum DSM 6724™ Reveals a Specialized Carbohydrate Fermentor
The Complete Genome Sequence of Hyperthermophile Dictyoglomus turgidum DSM 6724™ Reveals a Specialized Carbohydrate Fermentor Open
Here we report the complete genome sequence of the chemoorganotrophic, extremely thermophilic bacterium, Dictyoglomus turgidum, which is a Gram negative, strictly anaerobic bacterium. D. turgidum and D. thermophilum together form the Dicty…
View article: Molecular Diagnostic Field Test for Point-of-Care Detection of Ebola Virus Directly From Blood
Molecular Diagnostic Field Test for Point-of-Care Detection of Ebola Virus Directly From Blood Open
A molecular diagnostic method for robust detection of Ebola virus (EBOV) at the point of care (POC) directly from blood samples is described. This assay is based on reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) of …
View article: Erratum to: Complete genome sequences of Geobacillus sp. Y412MC52, a xylan-degrading strain isolated from obsidian hot spring in Yellowstone National Park
Erratum to: Complete genome sequences of Geobacillus sp. Y412MC52, a xylan-degrading strain isolated from obsidian hot spring in Yellowstone National Park Open
After publication of this study [1], the authors noticed that GenBank accession number is incorrect. The correct GenBank accession number is CP002442.