David J. Pinsky
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View article: Polymerized Salicylic Acid Microparticles Reduce the Progression and Formation of Human Neutrophil Extracellular Traps (NET)s
Polymerized Salicylic Acid Microparticles Reduce the Progression and Formation of Human Neutrophil Extracellular Traps (NET)s Open
Neutrophils can contribute to inflammatory disease propagation via innate mechanisms intended for inflammation resolution. For example, neutrophil extracellular traps (NETs) are necessary for trapping pathogens but can contribute to clot f…
View article: Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19
Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19 Open
BACKGROUND: SARS-CoV-2 infections cause COVID-19 and are associated with inflammation, coagulopathy, and high incidence of thrombosis. Myeloid cells help coordinate the initial immune response in COVID-19. Although we appreciate that myelo…
View article: Circulating Ectonucleotidases Signal Impaired Myocardial Perfusion at Rest and Stress
Circulating Ectonucleotidases Signal Impaired Myocardial Perfusion at Rest and Stress Open
Background Ectonucleotidases maintain vascular homeostasis by metabolizing extracellular nucleotides, modulating inflammation and thrombosis, and potentially, myocardial flow through adenosine generation. Evidence implicates dysfunction or…
View article: Cargo-free particles divert neutrophil-platelet aggregates to reduce thromboinflammation
Cargo-free particles divert neutrophil-platelet aggregates to reduce thromboinflammation Open
The combination of inflammation and thrombosis is a hallmark of many cardiovascular diseases. Under such conditions, platelets are recruited to an area of inflammation by forming platelet-leukocyte aggregates via interaction of PSGL-1 on l…
View article: Cargo-Free Particles Divert Neutrophil-Platelet Aggregates to Reduce Thromboinflammation
Cargo-Free Particles Divert Neutrophil-Platelet Aggregates to Reduce Thromboinflammation Open
Neutrophil-platelet vascular wall adhesion data in vitro and in vivo in the presence or absence of polymeric nanoparticles.
View article: Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis
Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis Open
People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which are strongly assoc…
View article: Hypoxic pulmonary vasoconstriction as a regulator of alveolar-capillary oxygen flux: A computational model of ventilation-perfusion matching
Hypoxic pulmonary vasoconstriction as a regulator of alveolar-capillary oxygen flux: A computational model of ventilation-perfusion matching Open
The relationship between regional variabilities in airflow (ventilation) and blood flow (perfusion) is a critical determinant of gas exchange efficiency in the lungs. Hypoxic pulmonary vasoconstriction is understood to be the primary activ…
View article: New (re)purpose for an old drug: purinergic modulation may extinguish the COVID-19 thromboinflammatory firestorm
New (re)purpose for an old drug: purinergic modulation may extinguish the COVID-19 thromboinflammatory firestorm Open
Purinergic signaling is discussed as a potential therapeutic target to reduced COVID-19 severity.
View article: CD73 Promotes Age-Dependent Accretion of Atherosclerosis
CD73 Promotes Age-Dependent Accretion of Atherosclerosis Open
Objective: CD73 is an ectonucleotidase which catalyzes the conversion of AMP (adenosine monophosphate) to adenosine. Adenosine has been shown to be anti-inflammatory and vasorelaxant. The impact of ectonucleotidases on age-dependent athero…
View article: Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome Open
Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with antiphospholipid syndrome (APS). Surface adenosine receptors trigger cycl…
View article: ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis
ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis Open
Deep vein thrombosis (DVT), caused by alterations in venous homeostasis is the third most common cause of cardiovascular mortality; however, key molecular determinants in venous thrombosis have not been fully elucidated. Several lines of e…
View article: Tuning the Thromboinflammatory Response to Venous Flow Interruption by the Ectonucleotidase CD39
Tuning the Thromboinflammatory Response to Venous Flow Interruption by the Ectonucleotidase CD39 Open
Objective— Leukocyte flux contributes to thrombus formation in deep veins under pathological conditions, but mechanisms that inhibit venous thrombosis are incompletely understood. Ectonucleotide di(tri)phosphohydrolase 1 ( ENTPD1 or Cd39 )…
View article: Ectonucleotidase-Mediated Suppression of Lupus Autoimmunity and Vascular Dysfunction
Ectonucleotidase-Mediated Suppression of Lupus Autoimmunity and Vascular Dysfunction Open
These data are the first to link ectonucleotidases with lupus autoimmunity and vascular disease. New therapeutic strategies may harness purinergic nucleotide dissipation or signaling to limit the damage inflicted upon organs and blood vess…
View article: CD39 AS A CRITICAL ECTONUCLEOTIDASE DEFENSE AGAINST PATHOLOGICAL VASCULAR REMODELING.
CD39 AS A CRITICAL ECTONUCLEOTIDASE DEFENSE AGAINST PATHOLOGICAL VASCULAR REMODELING. Open
A common thread underlying vascular or tissue injury is the loss of plasmalemmal integrity and the passive (or even active) spillage of intracellular contents into the circulation. Purinergic nucleotides, which serve as energy shuttling mo…
View article: Ischemic Cerebroprotection Conferred by Myeloid Lineage-Restricted or Global CD39 Transgene Expression
Ischemic Cerebroprotection Conferred by Myeloid Lineage-Restricted or Global CD39 Transgene Expression Open
Background: Cerebral tissue damage after an ischemic event can be exacerbated by inflammation and thrombosis. Elevated extracellular ATP and ADP levels are associated with cellular injury, inflammation, and thrombosis. Ectonucleoside triph…
View article: Ectonucleotidase CD39-driven control of postinfarction myocardial repair and rupture
Ectonucleotidase CD39-driven control of postinfarction myocardial repair and rupture Open
Mechanical complications of myocardial infarction (MI) are often fatal. Little is known about endogenous factors that predispose to myocardial rupture after MI. Ectonucleoside triphosphate diphosphohydrolase (CD39) could be a critical medi…
View article: In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody–Mediated Venous Thrombosis
In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody–Mediated Venous Thrombosis Open
Objective Antiphospholipid syndrome (APS) is a leading acquired cause of thrombotic events. Although antiphospholipid antibodies have been shown to promote thrombosis in mice, the role of neutrophils has not been explicitly studied. The ai…
View article: Inflammatory Disequilibrium in Stroke
Inflammatory Disequilibrium in Stroke Open
Over the past several decades, there have been substantial advances in our knowledge of the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to the development of thrombolytic therapy as the cornerstone o…
View article: Purinergic dysregulation in pulmonary hypertension
Purinergic dysregulation in pulmonary hypertension Open
Despite the fact that nucleotides and adenosine help regulate vascular tone through purinergic signaling pathways, little is known regarding their contributions to the pathobiology of pulmonary arterial hypertension, a condition characteri…