David J. Polhemus — Impact Story

David J. Polhemus 2025 Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss 2025 • Mahmoud H. Elbatreek, Zhen Li, Xiaoman Yu, Natalie Gehred, Tatiana Gromova, Jingshu Chen, Naoto Muraoka, Martin Borch Jensen, Vinay K. Kartha, Chri... 2024 Vericiguat rescues cyclic guanosine monophosphate production in human aortic vascular smooth muscle cells and augments vasorelaxation in aortic rings exposed to high glucose 2024 • David J. Polhemus, Diego Almodiel, Nuria Amat-Codina, Tarek Harb, Efthymios Ziogos, Lakshmi Santhanam, Gary Gerstenblith, Thorsten M. Leucker 2024 VERICIGUAT RESCUES CYCLIC GUANOSINE MONOPHOSPHATE PRODUCTION IN HUMAN AORTIC VASCULAR SMOOTH MUSCLE CELLS AND AUGMENTS VASORELAXATION IN AORTIC RINGS EXPOSED TO HIGH GLUCOSE 2024 • David J. Polhemus, Diego Almodiel, Tarek Harb, Efthymios Ziogos, Nuria Amat-Codina, Mark J. Ranek, Lakshmi Santhanam, Gary Gerstenblith, Thorsten M... 2023 Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a “2‐Hit” Murine Model 2023 • Kyle B. LaPenna, Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, Traci Goodchild,... 2025 Vericiguat prevents high glucose-mediated impaired vascular smooth muscle cGMP production and vasorelaxation 2025 • David J. Polhemus, Diego Almodiel, Tarek Harb, Efthymios Ziogos, Nuria Amat-Codina, Mark J. Ranek, Lakshmi Santhanam, Gary Gerstenblith, Thorsten M... Open Author Page

Exploring foci of 2025-02-10 Vericiguat prevents high glucose-mediated impaired vascular smooth muscle cGMP production and vasorelaxation 2025-02-10 • David J. Polhemus, Diego Almodiel, Tarek Harb, Efthymios Ziogos, Nuria Amat-Codina, Mark J. Ranek, Lakshmi Santhanam, Gary Gerstenblith, Thorsten M... Normal endothelial cell dependent vascular smooth muscle cell function is mediated by nitric oxide (NO), which stimulates soluble guanylyl cyclase (sGC) production of the second messenger cyclic guanosine monophosphate (cGMP) leading to increased protein kinase G (PKG) activity and vascular smooth muscle relaxation. NO bioavailability is impaired in high glucose (HG). We tested the hypothesis that the sGC sensitizer vericiguat reverses HG-mediated decreased sGC activity in two experimental models, human aortic vas… Open Article Page

High-Rise (Novel) High School Prodigies Have It Easy Even In Another World High Vis Infinity On High Roswell High Legal High (South Korean Tv Series) Long Beach Polytechnic High School High-Throughput Screening High Plains (United States) Open Article Page

Exploring foci of 2025-09-29 Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss 2025-09-29 • Mahmoud H. Elbatreek, Zhen Li, Xiaoman Yu, Natalie Gehred, Tatiana Gromova, Jingshu Chen, Naoto Muraoka, Martin Borch Jensen, Vinay K. Kartha, Chri... Abstract BACKGROUND AND AIMS Heart failure with preserved ejection fraction (HFpEF) remains a therapeutic challenge. GLP-1 receptor agonists (GLP-1RAs) show clinical promise, and the prevailing hypothesis is that their benefits are primarily driven by weight loss and the downstream benefits of improved functional status. We investigated the weight loss-independent effects of low-dose GLP-1RA therapy in a clinically relevant rodent model of severe cardiometabolic HFpEF. METHODS Ten-week-old male ZSF1 obese rats wit… Open Article Page

Maggot Therapy Physical Therapy Craniosacral Therapy Inversion Therapy Oxygen Therapy Dialectical Behavior Therapy Collagen Induction Therapy Therapy Dog Negative-Pressure Wound Therapy Open Article Page

Exploring foci of 2024-04-14 Vericiguat rescues cyclic guanosine monophosphate production in human aortic vascular smooth muscle cells and augments vasorelaxation in aortic rings exposed to high glucose 2024-04-14 • David J. Polhemus, Diego Almodiel, Nuria Amat-Codina, Tarek Harb, Efthymios Ziogos, Lakshmi Santhanam, Gary Gerstenblith, Thorsten M. Leucker <p class="first" dir="auto" id="d1150034e140"> <b>Background:</b>Vascular smooth muscle cell (VSMC) function relies on endothelial derived nitric oxide (NO) to stimulate cyclic guanosine monophosphate (cGMP) production through soluble guanylyl cyclase (sGC), and vasorelaxation. In inflammatory contexts like high glucose (HG), NO availability is reduced. We investigated whether vericiguat, an sGC stimulator, enhances cGMP production in HG exposed VSMCs and vasorelaxation in isolated aortic rings. <p dir="auto" id="… Open Article Page

Cyclic Voltammetry Computation Of Cyclic Redundancy Checks Cyclic Group Cyclic Adenosine Monophosphate Cyclic Permutation Cyclic Redundancy Check Cyclic Model Cyclic Compound Cyclic Guanosine Monophosphate Open Article Page

Exploring foci of 2024-06-22 VERICIGUAT RESCUES CYCLIC GUANOSINE MONOPHOSPHATE PRODUCTION IN HUMAN AORTIC VASCULAR SMOOTH MUSCLE CELLS AND AUGMENTS VASORELAXATION IN AORTIC RINGS EXPOSED TO HIGH GLUCOSE 2024-06-22 • David J. Polhemus, Diego Almodiel, Tarek Harb, Efthymios Ziogos, Nuria Amat-Codina, Mark J. Ranek, Lakshmi Santhanam, Gary Gerstenblith, Thorsten M... Abstract Background Normal endothelial cell dependent vascular smooth muscle cell function is mediated by nitric oxide (NO), which stimulates soluble guanylyl cyclase (sGC) production of the second messenger, cyclic guanosine monophosphate (cGMP) leading to increased protein kinase G (PKG) activity and vascular smooth muscle relaxation. NO bioavailability is impaired in inflammatory settings, such as high glucose (HG). We examined whether the direct sGC sensitizer/stimulator vericiguat, augments cGMP production in… Open Article Page

Cyclic Voltammetry Computation Of Cyclic Redundancy Checks Cyclic Group Cyclic Permutation Cyclic Redundancy Check Cyclic Model Cyclic Adenosine Monophosphate Cyclic Compound Cyclic Guanosine Monophosphate Open Article Page

Exploring foci of 2023-02-08 Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a “2‐Hit” Murine Model 2023-02-08 • Kyle B. LaPenna, Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, Traci Goodchild,... Background Recent studies have suggested that cardiac nitrosative stress mediated by pathological overproduction of nitric oxide (NO) via inducible NO synthase (iNOS) contributes to the pathogenesis of heart failure with preserved ejection fraction (HFpEF). Other studies have suggested that endothelial NO synthase (eNOS) dysfunction and attenuated NO bioavailability contribute to HFpEF morbidity and mortality. We sought to further investigate dysregulated NO signaling and to examine the effects of a NO‐based dual … Open Article Page

Sodium Oxybate Sodium Sulfide Sodium Fluoroacetate Sodium Methoxide Sodium Metasilicate Sodium-Vapor Lamp Sodium Polyacrylate Sodium Chlorate Sodium Hexametaphosphate Open Article Page