David J. Rickard
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View article: Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin
Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin Open
Our work describes a progressive series of assays to demonstrate the potential clinical value of a novel RORγ inverse agonist small molecule with high potency and selectivity, which will enter clinical trials in late 2015 for psoriasis pat…
View article: MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses
MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses Open
CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and other pathways. Previous studies have suggested that as part of this complex, MALT1 functions as both a scaffolding protein to activate NF-κB through rec…