David J. Schaeffer
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View article: A Deep Learning Framework for Classification of Neuroendocrine Neoplasm Whole Slide Images
A Deep Learning Framework for Classification of Neuroendocrine Neoplasm Whole Slide Images Open
Background/Objectives: Neuroendocrine neoplasms (NENs) are uncommon neoplasms. Grading informs the prognosis and treatment decision of NENs and is determined by cell proliferation, which is measured by mitotic count and Ki-67 index. These …
View article: Diagnostic findings of copper, selenium and manganese deficiency in dairy and beef cattle submitted to the California Animal Health and Food Safety Laboratory
Diagnostic findings of copper, selenium and manganese deficiency in dairy and beef cattle submitted to the California Animal Health and Food Safety Laboratory Open
Copper (Cu), selenium (Se) and manganese (Mn) concentrations in 1,490 beef and dairy cattle livers submitted to the California Animal Health & Food Safety Lab System (CAHFS) laboratory between 2012 and 2021 were analyzed. The aim was to…
View article: Percutaneous extracapsular repair as a cost-effective alternative for treating cranial cruciate ligament deficiency in dogs
Percutaneous extracapsular repair as a cost-effective alternative for treating cranial cruciate ligament deficiency in dogs Open
Objective To evaluate the duration of surgery, cost, and outcomes associated with percutaneous placement of a lateral fabellotibial suture (pLFS) in dogs with unilateral cranial cruciate ligament deficiency (CCLD) treated in a low-cost cli…
View article: Noninvasive focal gene transfer of chemogenetic proteins in the primate brain
Noninvasive focal gene transfer of chemogenetic proteins in the primate brain Open
The development of chemogenetic neuromodulators, including Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), have enabled focally specific, long-lasting, and reversible neuromodulation in the primate brain. Although sys…
View article: Improving Access to Hereditary Testing in Pancreatic Ductal Carcinoma
Improving Access to Hereditary Testing in Pancreatic Ductal Carcinoma Open
PURPOSE Approximately 5%-10% of patients with pancreatic ductal adenocarcinoma (PDAC) have an inherited basis, yet uptake of genetic testing remains low and subject to disparities. This study compared two genetic testing pathways available…
View article: Inflammatory Bowel Disease Uncovered in Fecal Immunochemical Test Positive Patients in a Canadian Provincial Colon Cancer Screening Program
Inflammatory Bowel Disease Uncovered in Fecal Immunochemical Test Positive Patients in a Canadian Provincial Colon Cancer Screening Program Open
Objectives: Inflammatory Bowel Disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory condition that usually affects younger adults but has a second incidence peak in the older population. Mos…
View article: Implementation and evaluation of a national quality improvement initiative in cancer surgery
Implementation and evaluation of a national quality improvement initiative in cancer surgery Open
Background In 2017, the Canadian Partnership Against Cancer, a Canadian federally sponsored organisation, initiated a national multijurisdictional quality improvement (QI) initiative to maximise the use of synoptic data to drive cancer sys…
View article: Analysis of published and clinical sample data to develop new ranges of liver and blood concentrations of vitamin A for diagnosis of vitamin A deficiency in cattle
Analysis of published and clinical sample data to develop new ranges of liver and blood concentrations of vitamin A for diagnosis of vitamin A deficiency in cattle Open
In cattle, liver stores of vitamin A (VA) maintain blood VA concentrations until liver supplies are nearly exhausted, providing VA to tissues during insufficient dietary intake. Therefore, normal blood levels do not indicate adequate VA,…
View article: Ex vivo comparison of pin placement with patient‐specific drill guides or freehand technique in canine cadaveric spines
Ex vivo comparison of pin placement with patient‐specific drill guides or freehand technique in canine cadaveric spines Open
Objective To compare vertebral implant placement in the canine thoracolumbar spine between 3D‐printed patient‐specific drill guides (3DPG) and the conventional freehand technique (FH). Study design Ex vivo study. Animals Cadaveric canine s…
View article: Well-Differentiated Grade 3 Neuroendocrine Tumors
Well-Differentiated Grade 3 Neuroendocrine Tumors Open
Objectives We evaluated a population-based cohort of metastatic well-differentiated grade 3 gastroenteropancreatic neuroendocrine tumors (G3 NETs) to describe their characteristics, prognosis, and treatment outcomes. Methods The British Co…
View article: The effect of repeated freezing and thawing on the suture pull‐out strength in equine arytenoid and cricoid cartilages
The effect of repeated freezing and thawing on the suture pull‐out strength in equine arytenoid and cricoid cartilages Open
Objective To assess the effect of repeated freezing and thawing on the suture pull‐out strength in arytenoid and cricoid cartilages subjected to the laryngoplasty (LP) procedure. Study design Ex vivo experimental study. Sample population T…
View article: Kinetic Analysis in Horses With Deep Digital Flexor Tendinopathy Within the Digit Diagnosed by Magnetic Resonance Imaging
Kinetic Analysis in Horses With Deep Digital Flexor Tendinopathy Within the Digit Diagnosed by Magnetic Resonance Imaging Open
Objectives To determine the stance duration and ground reaction forces (GRF) of horses with deep digital flexor (DDF) tendinopathy at the level of the foot and compare the stance duration and GRF to those of clinically sound horses. Design…
View article: Three-dimensional hydrogel culture systems support growth and determination of chemosensitivity of feline sarcoma and carcinoma cell lines
Three-dimensional hydrogel culture systems support growth and determination of chemosensitivity of feline sarcoma and carcinoma cell lines Open
OBJECTIVE To evaluate feline injection site-associated sarcoma (FISAS) and oral squamous cell carcinoma (FOSCC) cells in 3-D hydrogel-based cell cultures to determine chemosensitivity to carboplatin at concentrations comparable to those el…
View article: Three-dimensional hydrogel culture systems support growth and determination of chemosensitivity of feline sarcoma and carcinoma cell lines
Three-dimensional hydrogel culture systems support growth and determination of chemosensitivity of feline sarcoma and carcinoma cell lines Open
OBJECTIVE To evaluate feline injection site-associated sarcoma (FISAS) and oral squamous cell carcinoma (FOSCC) cells in 3-D hydrogel-based cell cultures to determine chemosensitivity to carboplatin at concentrations comparable to those el…
View article: USCAP 2022 Abstracts: Liver Pathology (1018-1075)
USCAP 2022 Abstracts: Liver Pathology (1018-1075) Open
Background: Men and post-menopausal women are at increased risk of developing non-alcoholic steatohepatitis (NASH) compared to pre-menopausal women.However, the impact of age and gender on NASH progression remains controversial.We sought t…