David J. Stott
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View article: A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels Open
Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine (TOPMed) program …
View article: Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles
Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles Open
Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compa…
View article: A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels Open
Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine (TOPMed) program …
View article: Prevalence, Trajectory, and Predictors of Poststroke Pain: Retrospective Analysis of Pooled Clinical Trial Data Set
Prevalence, Trajectory, and Predictors of Poststroke Pain: Retrospective Analysis of Pooled Clinical Trial Data Set Open
BACKGROUND: Poststroke pain remains underdiagnosed and inadequately managed. To inform the optimum time to initiate interventions, we examined prevalence, trajectory, and participant factors associated with poststroke pain. METHODS: Eligib…
View article: Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults
Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults Open
Context With age, the prevalence of subclinical hypothyroidism rises. However, incidence and determinants of spontaneous normalization remain largely unknown. Objective To investigate incidence and determinants of spontaneous normalization…
View article: Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles
Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles Open
Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compa…
View article: Weight loss, visit-to-visit body weight variability and cognitive function in older individuals
Weight loss, visit-to-visit body weight variability and cognitive function in older individuals Open
Objective to investigate the association between variability and loss of body weight with subsequent cognitive performance and activities of daily living in older individuals. Design cross-sectional cohort study. Setting PROspective Study …
View article: Comparative validity of informant tools for assessing pre‐stroke cognitive impairment
Comparative validity of informant tools for assessing pre‐stroke cognitive impairment Open
Objectives Various informant‐based questionnaires are used in clinical practice to screen for pre‐stroke cognitive problems. However, there is no guidance on which tool should be preferred. We compared the validity of the two most commonly…
View article: No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials
No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials Open
Context Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence with advancing age. Objective The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin le…
View article: Hospital at Home admission avoidance with comprehensive geriatric assessment to maintain living at home for people aged 65 years and over: a RCT
Hospital at Home admission avoidance with comprehensive geriatric assessment to maintain living at home for people aged 65 years and over: a RCT Open
Background Evidence is required to guide the redesign of health care for older people who require hospital admission. Objectives We assessed the clinical effectiveness and cost-effectiveness of geriatrician-led admission avoidance hospital…
View article: Is comprehensive geriatric assessment hospital at home a cost-effective alternative to hospital admission for older people?
Is comprehensive geriatric assessment hospital at home a cost-effective alternative to hospital admission for older people? Open
Background hospital level healthcare in the home guided by comprehensive geriatric assessment (CGA) might provide a less costly alternative to hospitalisation for older people. Objective to determine the cost-effectiveness of CGA admission…
View article: Comparing performance on the Months of the Year Backwards test in hospitalised patients with delirium, dementia, and no cognitive impairment: an exploratory study
Comparing performance on the Months of the Year Backwards test in hospitalised patients with delirium, dementia, and no cognitive impairment: an exploratory study Open
Purpose To investigate performance of the Months of the Year Backwards (MOTYB) test in older hospitalised patients with delirium, dementia, and no cognitive impairment. Methods Secondary analysis of data from a case–control study of 149 ho…
View article: Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials
Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials Open
Background The cardiovascular effects of treating older adults with subclinical hypothyroidism (SCH) are uncertain. Although concerns have been raised regarding a potential increase in cardiovascular side effects from thyroid hormone repla…
View article: Is Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons?
Is Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? Open
The National Institute for Health Research Health Services and Delivery Research Programme (12/209/66).
View article: Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke: Meta-analysis From 7 Prospective Cohorts.
Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke: Meta-analysis From 7 Prospective Cohorts. Open
We found association of amino acids, glycolysis-related metabolites, acute-phase reaction markers, and several lipoprotein subfractions with the risk of stroke. These findings support the potential of metabolomics to provide new insights i…
View article: Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality
Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality Open
Aims Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflamm…
View article: Is comprehensive geriatric assessment hospital at home a cost-effective alternative to hospital admission for older people?
Is comprehensive geriatric assessment hospital at home a cost-effective alternative to hospital admission for older people? Open
Background\nhospital level healthcare in the home guided by comprehensive geriatric assessment (CGA) might provide a less costly alternative to hospitalisation for older people.\n\nObjective\nto determine …
View article: Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke
Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke Open
Objective To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings.MethodsWe investigated the association of metabolites with risk of stroke in 7 prospective cohort s…
View article: Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial
Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial Open
Background Fatigue often triggers screening for and treatment of subclinical hypothyroidism. However, data on the impact of levothyroxine on fatigue is limited and previous studies might not have captured all aspects of fatigue. Method Thi…
View article: L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms
L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms Open
European Union FP7.
View article: The work of older people and their informal caregivers in managing an acute health event in a hospital at home or hospital inpatient setting
The work of older people and their informal caregivers in managing an acute health event in a hospital at home or hospital inpatient setting Open
Background There is limited understanding of the contribution made by older people and their caregivers to acute healthcare in the home and how this compares to hospital inpatient healthcare. Objectives To explore the work of older people …
View article: Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis
Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis Open
BACKGROUND: Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentratio…
View article: Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium
Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium Open
BackgroundData are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting.…
View article: A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium
A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium Open
BACKGROUND: Increased heart rate and a prolonged QT interval are important risk factors for cardiovascular morbidity and mortality, and can be influenced by the use of various medications, including tricyclic/tetracyclic antidepressants (T…
View article: Alcohol and mortality in older people: understanding the J-shaped curve
Alcohol and mortality in older people: understanding the J-shaped curve Open
Key points:
• The harms of drinking alcohol to excess are widely accepted. However, it has been claimed that there are health benefits from low–moderate levels of drinking, including improved survival in older people.
• There is …
View article: The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial
The Impact of Levothyroxine on Cardiac Function in Older Adults With Mild Subclinical Hypothyroidism: A Randomized Clinical Trial Open
View article: The association of kidney function and cognitive decline in older patients at risk of cardiovascular disease: a longitudinal data analysis
The association of kidney function and cognitive decline in older patients at risk of cardiovascular disease: a longitudinal data analysis Open
View article: A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients
A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients Open
Background: Delirium is a common and serious acute neuropsychiatric syndrome which is often missed in routine clinical care. Inattention is the core cognitive feature. Diagnostic test accuracy (including cut-points) of a smartphone Deliriu…
View article: New horizons in iron deficiency anaemia in older adults
New horizons in iron deficiency anaemia in older adults Open
Iron deficiency anaemia (IDA) is common in older adults and associated with a range of adverse outcomes. Differentiating iron deficiency from other causes of anaemia is important to ensure appropriate investigations and treatment. It is po…
View article: The kidney, subclinical thyroid disease and cardiovascular outcomes in older patients
The kidney, subclinical thyroid disease and cardiovascular outcomes in older patients Open
Objective Thyroid hormones have been implicated to play a role in cardiovascular disease, along with studies linking thyroid hormone to kidney function. The aim of this study is to investigate whether kidney function modifies the associati…