David J.E. Callaway
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View article: Nanoscale dynamics of the cadherin–catenin complex bound to vinculin revealed by neutron spin echo spectroscopy
Nanoscale dynamics of the cadherin–catenin complex bound to vinculin revealed by neutron spin echo spectroscopy Open
We report a neutron spin echo (NSE) study of the nanoscale dynamics of the cell–cell adhesion cadherin–catenin complex bound to vinculin. Our measurements and theoretical physics analyses of the NSE data reveal that the dynamics of full-le…
View article: Activated nanoscale actin-binding domain motion in the catenin–cadherin complex revealed by neutron spin echo spectroscopy
Activated nanoscale actin-binding domain motion in the catenin–cadherin complex revealed by neutron spin echo spectroscopy Open
Significance Mechanical force affects fundamental processes in biology like cell adhesion, tissue morphogenesis, and tumorigenesis. The molecular mechanisms by which cells utilize their protein machineries to sense and transduce mechanical…
View article: An ensemble of flexible conformations underlies mechanotransduction by the cadherin–catenin adhesion complex
An ensemble of flexible conformations underlies mechanotransduction by the cadherin–catenin adhesion complex Open
Significance Adherens junctions are specialized cell–cell adhesion complexes found in epithelial, endothelial, and neuronal tissues of multicellular organism. The cadherin–catenin complex is the core component of the adherens junction and …
View article: Neutron scattering in the biological sciences: progress and prospects
Neutron scattering in the biological sciences: progress and prospects Open
The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent develo…
View article: Alpha-catenin structure in solution and in complex with F-actin as revealed by small-angle X-ray and neutron scattering
Alpha-catenin structure in solution and in complex with F-actin as revealed by small-angle X-ray and neutron scattering Open
As a core component of the adherens junction, the F-actin binding protein -catenin stabilizes the cadherin/catenin complexes to the actin cytoskeleton for the mechanical coupling of cell-cell adhesion.Additionally, -catenin regulates actin…
View article: Controllable activation of nanoscale dynamics in a disordered protein alters binding kinetics
Controllable activation of nanoscale dynamics in a disordered protein alters binding kinetics Open
The phosphorylation of specific residues in a flexible disordered activation loop yields precise control of signal transduction. One paradigm is the phosphorylation of S339/S340 in the intrinsically disordered tail of the multi-domain scaf…
View article: Phosphatidylinositol 4,5-Bisphosphate Clusters the Cell Adhesion Molecule CD44 and Assembles a Specific CD44-Ezrin Heterocomplex, as Revealed by Small Angle Neutron Scattering
Phosphatidylinositol 4,5-Bisphosphate Clusters the Cell Adhesion Molecule CD44 and Assembles a Specific CD44-Ezrin Heterocomplex, as Revealed by Small Angle Neutron Scattering Open
The cell adhesion molecule CD44 regulates diverse cellular functions, including cell-cell and cell-matrix interaction, cell motility, migration, differentiation, and growth. In cells, CD44 co-localizes with the membrane-cytoskeleton adapte…