J. David Jentsch
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View article: Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations
Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations Open
Genetic and other predisposing factors can influence the progression from initiation of drug intake to compulsive substance use through distinct biobehavioral processes. Operant cocaine self-administration studies in laboratory mice offer …
View article: Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations
Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations Open
Genetic and other predisposing factors can influence the progression from initiation of drug intake to compulsive substance use through distinct biobehavioral processes. Operant cocaine self-administration studies in laboratory mice offer …
View article: Differing genetics of saline and cocaine self-administration in the hybrid mouse diversity panel
Differing genetics of saline and cocaine self-administration in the hybrid mouse diversity panel Open
To identify genes that regulate the response to the potentially addictive drug cocaine, we performed a control experiment using genome-wide association studies (GWASs) and RNA-Seq of a panel of inbred and recombinant inbred mice undergoing…
View article: Dysbindin-1 Mutation Alters Prefrontal Cortex Extracellular Glutamate and Dopamine In Vivo
Dysbindin-1 Mutation Alters Prefrontal Cortex Extracellular Glutamate and Dopamine In Vivo Open
Elevated risk for schizophrenia is associated with a variation in the DTNBP1 gene encoding dysbindin-1, which may underpin cognitive impairments in this prevalent neuropsychiatric disorder. The cognitive symptoms of schizophrenia involve a…
View article: Neuron Navigator 1 (Nav1) regulates the response to cocaine in mice
Neuron Navigator 1 (Nav1) regulates the response to cocaine in mice Open
Genetic variation accounts for much of the risk for developing a substance use disorder, but the underlying genetic factors and their genetic effector mechanisms are mostly unknown. Inbred mouse strains exhibit substantial and heritable di…
View article: <i>Neuron Navigator 1</i>Regulates Learning, Memory, and the Response to Multiple Potentially Addictive Drugs
<i>Neuron Navigator 1</i>Regulates Learning, Memory, and the Response to Multiple Potentially Addictive Drugs Open
Genetic variation accounts for much of the risk for developing a substance use disorder (SUD). Inbred mouse strains exhibit substantial and heritable differences in the extent of voluntary cocaine intravenous self-administration (IVSA). Co…
View article: Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in inbred and recombinant inbred mice
Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in inbred and recombinant inbred mice Open
To identify genetic pathways for addiction, we analyzed intravenous self-administration of cocaine or saline in a panel of 84 inbred and recombinant inbred mouse strains over 10 days. We integrated the behavior data with RNA-Seq data from …
View article: Gonadal Sex and Sex-Chromosome Complement Interact to Affect Ethanol Consumption in Adolescent Four Core Genotypes Mice
Gonadal Sex and Sex-Chromosome Complement Interact to Affect Ethanol Consumption in Adolescent Four Core Genotypes Mice Open
Background Sex differences in ethanol consumption have been reported in both humans and laboratory rodents, but the independent/dependent contributions of genetic and hormonal sex◻biasing mechanisms to these phenotypes have not yet been fu…
View article: Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel
Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel Open
Cocaine self‐administration is a complexly determined trait, with a substantial proportion of individual differences being determined by genetic variation. However, the relevant genetic variants that drive heritable differences in cocaine …
View article: The Collaborative Cross strains and their founders vary widely in cocaine-induced behavioral sensitization
The Collaborative Cross strains and their founders vary widely in cocaine-induced behavioral sensitization Open
Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United States in the last 10 years. Despite the prevalence of cocaine use disorder (CUD) and the personal and societal problems it presents, there ar…
View article: Reversal Learning Phenotypes are Linked with Novel Genetic Loci in Diversity Outbred Mice
Reversal Learning Phenotypes are Linked with Novel Genetic Loci in Diversity Outbred Mice Open
Impulsive behavior and impulsivity are heritable phenotypes that are strongly associated with risk for substance use disorders in human subjects. Consequently, identifying the neurogenetic mechanisms that influence impulsivity may also rev…
View article: Genetic pathways regulating the longitudinal acquisition of cocaine self administration in mice
Genetic pathways regulating the longitudinal acquisition of cocaine self administration in mice Open
To identify genetic pathways for addiction, we analyzed intravenous self-administration of cocaine or saline in a panel of 84 inbred and recombinant inbred mouse strains over 10 days. We integrated the behavior data with RNA-Seq data from …
View article: <i>Syn3</i> Gene Knockout Negatively Impacts Aspects of Reversal Learning Performance
<i>Syn3</i> Gene Knockout Negatively Impacts Aspects of Reversal Learning Performance Open
Behavioral flexibility enables the ability to adaptively respond to changes in contingency requirements to maintain access to desired outcomes, and deficits in behavioral flexibility have been documented in many psychiatric disorders. Prev…
View article: Extreme Phenotypic Diversity in Operant Responding for an Intravenous Cocaine or Saline Infusion in the Hybrid Mouse Diversity Panel
Extreme Phenotypic Diversity in Operant Responding for an Intravenous Cocaine or Saline Infusion in the Hybrid Mouse Diversity Panel Open
Cocaine self-administration is complexly determined trait, and a substantial proportion of individual differences in cocaine use is determined by genetic variation. Cocaine intravenous self-administration (IVSA) procedures in laboratory an…
View article: Heritability of ethanol consumption and pharmacokinetics in a genetically diverse panel of Collaborative Cross mouse strains and their inbred founders
Heritability of ethanol consumption and pharmacokinetics in a genetically diverse panel of Collaborative Cross mouse strains and their inbred founders Open
Background Inter-individual variation in voluntary ethanol consumption and ethanol response is partially influenced by genetic variation. Discovery of the genes and allelic variants that affect these phenotypes may clarify the etiology and…
View article: Dopamine D2 Receptors in Dopaminergic Neurons Modulate Performance in a Reversal Learning Task in Mice
Dopamine D2 Receptors in Dopaminergic Neurons Modulate Performance in a Reversal Learning Task in Mice Open
Neuroimaging studies in animal models and human subjects have each revealed that relatively low striatal dopamine D2-like receptor binding potential is associated with poor impulse control and with vulnerability for addiction-related behav…
View article: Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate
Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate Open
By analyzing multi-tissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalogue of expression quantitative trait loci (eQTLs)…