David K. Klassen
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View article: Assessing colorectal cancer screening and outcomes among First Nations people in Alberta
Assessing colorectal cancer screening and outcomes among First Nations people in Alberta Open
Background First Nations (FN) people in Canada are commonly diagnosed with colorectal cancers. Although Canada has treaty responsibilities to ensure FNs people have equitable access to quality health services, access to colorectal cancer s…
View article: Postoperative fluid restriction to prevent delayed hyponatremia after endoscopic transsphenoidal surgery
Postoperative fluid restriction to prevent delayed hyponatremia after endoscopic transsphenoidal surgery Open
Background Readmission following endoscopic endonasal transsphenoidal surgery (EETS) for pituitary neuroendocrine tumor (PitNET) and other sellar pathology is most commonly due to delayed hyponatremia. Studies suggest postoperative fluid r…
View article: Impact of removing OPTN region from vascularized composite allograft allocation
Impact of removing OPTN region from vascularized composite allograft allocation Open
On 6/18/2020, the Organ Procurement and Transplantation Network (OPTN) implemented new policy replacing OPTN region with a 500 nautical mile (NM) circle around the donor hospital for the purpose of vascularized composite allograft (VCA) al…
View article: To B or Not to B Remains a Question
To B or Not to B Remains a Question Open
Equity in organ allocation has challenged the Organ Procurement and Transplantation Network (OPTN) since its inception in 1986. Inequity was recognized to be multifactorial and the result factors, such as differences between donor and reci…
View article: 1993. Donor-Derived Transmission of Candida species: 10-year Analysis from the OPTN ad hoc Disease Transmission Advisory Committee (DTAC)
1993. Donor-Derived Transmission of Candida species: 10-year Analysis from the OPTN ad hoc Disease Transmission Advisory Committee (DTAC) Open
Background Solid organ transplantation (SOT) is lifesaving, but donor-derived infections can be associated with significant morbidity and mortality. Candida species are common colonizers in deceased donors managed in the intensive care env…
View article: Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Through Solid Organ Transplantation and Outcomes of Coronavirus Disease 2019 Among Recent Transplant Recipients
Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Through Solid Organ Transplantation and Outcomes of Coronavirus Disease 2019 Among Recent Transplant Recipients Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmissible through lung transplantation, and outcomes among infected organ recipients may be severe. Transmission risk to extrapulmonary organ recipients and rec…
View article: Risk and reward: Balancing safety and maximizing lung donors during the COVID-19 pandemic
Risk and reward: Balancing safety and maximizing lung donors during the COVID-19 pandemic Open
In response to Kaul et al.’s article (page 2885), the editorialists recommend testing lower respiratory tract samples from potential deceased lung donors for SARS-CoV-2 to mitigate the risk of donor derived disease.
View article: SARS-CoV-2 Infections among Recent Organ Recipients, March–May 2020, United States
SARS-CoV-2 Infections among Recent Organ Recipients, March–May 2020, United States Open
We conducted public health investigations of 8 organ transplant recipients who tested positive for severe acute respiratory syndrome coronavirus 2 infection. Findings suggest the most likely source of transmission was community or healthca…
View article: New Answers to Old Questions: Waitlist Versus Transplant Outcomes in the Coronavirus Disease 2019 Era
New Answers to Old Questions: Waitlist Versus Transplant Outcomes in the Coronavirus Disease 2019 Era Open
See Clinical Research on Page 46 See Clinical Research on Page 46 The coronavirus disease 2019 (COVID-19) pandemic has dramatically affected health care systems and health outcomes around the world. Transplantation has responded with criti…
View article: Maximizing donors’ gifts: A comparison of actual and expected solid organ yield among VCA donors
Maximizing donors’ gifts: A comparison of actual and expected solid organ yield among VCA donors Open
Vascularized Composite Allograft (VCA) transplantation provides life-changing transplants, but VCA adds complexity to the donation process and timing, possibly impeding solid organ donation. Expanding upon descriptive analyses, this study …
View article: Can Behavioral Research Improve Transplant Decision-Making? A Mock Offer Study on the Role of Kidney Procurement Biopsies
Can Behavioral Research Improve Transplant Decision-Making? A Mock Offer Study on the Role of Kidney Procurement Biopsies Open
Background The use of procurement biopsies for assessing kidney quality has been implicated as a driver of the nearly 20% kidney discard rate in the United States. Yet in some contexts, biopsies may boost clinical confidence, enabling acce…
View article: Can donor narratives yield insights? A natural language processing proof of concept to facilitate kidney allocation
Can donor narratives yield insights? A natural language processing proof of concept to facilitate kidney allocation Open
Although expedited placement could ameliorate stagnant kidney utilization, precisely identifying difficult-to-place organs is crucial to mitigate potential harms associated with this policy. Existing algorithms have only leveraged structur…
View article: National landscape of HIV+ to HIV+ kidney and liver transplantation in the United States
National landscape of HIV+ to HIV+ kidney and liver transplantation in the United States Open
The HIV Organ Policy Equity (HOPE) Act, enacted on November 21, 2013, enables research on the transplantation of organs from donors infected with human immunodeficiency virus (HIV) (HIV+) into HIV+ individuals who, prior to transplantation…
View article: KAS Turns Four: The State of Deceased Donor Kidney Allocation in the U.S.
KAS Turns Four: The State of Deceased Donor Kidney Allocation in the U.S. Open
Background: This study examines very recent trends in deceased donor kidney transplantation to assess the performance of the kidney allocation system (KAS), implemented December 4, 2014, and whether bolus effects associated with KAS have s…
View article: Living kidney donor risk of ESRD
Living kidney donor risk of ESRD Open
To the Editor: We thank Dr Steiner for his comments on our recent paper on end-stage renal disease (ESRD) among prior living kidney donors.1Steiner R. GFR-related risks for kidney donors are here to stay, but what are they? [published onli…
View article: Vascularized composite allotransplantation in the United States: A descriptive analysis of the Organ Procurement and Transplantation Network Data
Vascularized composite allotransplantation in the United States: A descriptive analysis of the Organ Procurement and Transplantation Network Data Open
On July 3, 2014, the Organ Procurement and Transplantation Network/United Network for Organ Sharing was charged with the oversight of vascularized composite allograft (VCA) procurement and transplantation in the United States. As of Decemb…
View article: Social, economic, and policy implications of organ preservation advances
Social, economic, and policy implications of organ preservation advances Open
Organ preservation advances stand to increase local and global access to transplantation, improve transplant outcomes, and accelerate progress in related areas such as immune tolerance induction and xenotransplantation. This area holds the…
View article: Early Experience with the New Kidney Allocation System
Early Experience with the New Kidney Allocation System Open
Podcast This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2017_11_21_CJASNPodcast_18_1_v.mp3
View article: New Insights Into the Alleged Kidney Donor Profile Index Labeling Effect on Kidney Utilization
New Insights Into the Alleged Kidney Donor Profile Index Labeling Effect on Kidney Utilization Open
The Kidney Donor Profile Index (KDPI) became a driving factor in deceased donor kidney allocation on December 4, 2014, with the implementation of the kidney allocation system (KAS). On April 20, 2016, the annual recalibration of the Kidney…
View article: Delays in Prior Living Kidney Donors Receiving Priority on the Transplant Waiting List
Delays in Prior Living Kidney Donors Receiving Priority on the Transplant Waiting List Open
Background and objectives Prior living donors (PLDs) receive very high priority on the Organ Procurement and Transplantation Network (OPTN) kidney waiting list. Program delays in adding PLDs to the waiting list, setting their status to act…