David Klank
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View article: Lack of efficacy of Intrapleural applications of Trastuzumab for local Control in metastatic HER-2-positive Breast Cancer
Lack of efficacy of Intrapleural applications of Trastuzumab for local Control in metastatic HER-2-positive Breast Cancer Open
While systemic treatment for HER-2-positive breast cancer is well established, strategies for local progression, particularly pleural infiltration, are less clearly defined. In this case, a 52-year-old female patient with HER-2-positive, h…
View article: The Urine Light Chain/eGFR Quotient as a Tool to Rule out Cast Nephropathy in Myeloma-Associated Kidney Failure
The Urine Light Chain/eGFR Quotient as a Tool to Rule out Cast Nephropathy in Myeloma-Associated Kidney Failure Open
Kidney involvement with resulting kidney failure leads to increased mortality in patients with multiple myeloma (MM). Cast nephropathy (CN), in particular, if left untreated, quickly leads to kidney failure requiring dialysis and has a ver…
View article: Single Center Experience Using Monoclonal COVID-19 Antibodies in the Management of Immunocompromised Patients with COVID-19
Single Center Experience Using Monoclonal COVID-19 Antibodies in the Management of Immunocompromised Patients with COVID-19 Open
The medical care of immunocompromised patients with COVID-19 infection causes major hurdles in the management of these patients in clinical practice. However, poor responses to vaccinations in patients with oncological or autoimmune diseas…
View article: Histological Findings in Kidney Biopsies of Patients with Monoclonal Gammopathy—Always a Surprise
Histological Findings in Kidney Biopsies of Patients with Monoclonal Gammopathy—Always a Surprise Open
Background: The simultaneous occurrence of impaired kidney function and paraproteinemia is common in our constantly aging society. Both can be independent entities; however, renal insufficiency can also be caused by the paraprotein. We ass…
View article: Monoclonal Antibodies for the Prevention and Treatment of COVID-19 Disease in Patients With Hematological Malignancies: Two Case Reports and a Literature Review
Monoclonal Antibodies for the Prevention and Treatment of COVID-19 Disease in Patients With Hematological Malignancies: Two Case Reports and a Literature Review Open
The outbreak of coronavirus disease 2019 (COVID-19) pandemic has caused worldwide problems in the care of patients with hematological malignancies. Since the first reports on the new coronavirus severe acute respiratory syndrome coronaviru…
View article: Bedeutung des CD40 Liganden (CD40L) bei Patienten mit schwerer Sepsis und der Einfluss von aktiviertem Protein C
Bedeutung des CD40 Liganden (CD40L) bei Patienten mit schwerer Sepsis und der Einfluss von aktiviertem Protein C Open