David Kluth
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View article: #935 Rituximab for primary membranous nephropathy: a decade of experience
#935 Rituximab for primary membranous nephropathy: a decade of experience Open
Background and Aims Membranous nephropathy is a common cause of nephrotic syndrome in adults. Traditional glucocorticoid and cyclophosphamide treatment regimens have significant associated toxicity. Over the last two decades, immunological…
View article: The Situational Judgement Test: not the right answer for UK Foundation Programme Allocation
The Situational Judgement Test: not the right answer for UK Foundation Programme Allocation Open
Editor – Allocation to UK Foundation Programme training posts has long been an issue of contention. Following recent analysis of the allocation process, the UK Foundation Programme Office has now moved away from the use of a Situational Ju…
View article: Automated Item Generation: impact of item variants on performance and standard setting
Automated Item Generation: impact of item variants on performance and standard setting Open
Background Automated Item Generation (AIG) uses computer software to create multiple items from a single question model. There is currently a lack of data looking at whether item variants to a single question result in differences in stude…
View article: Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice
Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice Open
Acute kidney injury (AKI) is common and associated with increased risks of cardiovascular and chronic kidney disease. Causative molecular/physiological pathways are poorly defined. There are no therapies to improve long-term outcomes. An a…
View article: Automated Item Generation: – Impact of item variants on performance and standard setting
Automated Item Generation: – Impact of item variants on performance and standard setting Open
Background Automated Item Generation (AIG) uses computer software to create multiple items from a single question model. Items generated using AIG software have been shown to be of similar quality to those produced using traditional item w…
View article: Utility of interval kidney biopsy in ANCA-associated vasculitis
Utility of interval kidney biopsy in ANCA-associated vasculitis Open
Objectives ANCA-associated vasculitis (AAV) is a rare autoimmune disorder that commonly involves the kidney. Early identification of kidney involvement, assessing treatment-response and predicting outcome are important clinical challenges.…
View article: Variation in performance on common content items at UK medical schools
Variation in performance on common content items at UK medical schools Open
Background Due to differing assessment systems across UK medical schools, making meaningful cross-school comparisons on undergraduate students’ performance in knowledge tests is difficult. Ahead of the introduction of a national licensing …
View article: Variation in Performance on Common Content Items at UK Medical Schools
Variation in Performance on Common Content Items at UK Medical Schools Open
Background Due to the diverse approaches to medical school assessment, making meaningful cross-school comparisons on knowledge is difficult. Ahead of the introduction of national licensing assessment in the UK, we evaluate schools on “comm…
View article: Effect of remote online exam delivery on student experience and performance in applied knowledge tests
Effect of remote online exam delivery on student experience and performance in applied knowledge tests Open
Background The use of remote online delivery of summative assessments has been underexplored in medical education. Due to the COVID-19 pandemic, all end of year applied knowledge multiple choice question (MCQ) tests at one UK medical schoo…
View article: Long-term outcomes in elderly patients with ANCA-associated vasculitis
Long-term outcomes in elderly patients with ANCA-associated vasculitis Open
Objective ANCA-associated vasculitis (AAV) is a small vessel vasculitis that commonly presents in the elderly. However, there are few long-term outcome data for these patients. Here, we assessed long-term outcomes in a single-centre cohort…
View article: Using prescribing very short answer questions to identify sources of medication errors: a prospective study in two UK medical schools
Using prescribing very short answer questions to identify sources of medication errors: a prospective study in two UK medical schools Open
Objective To assess the utility and ability of the novel prescribing very short answer (VSA) question format to identify the sources of undergraduate prescribing errors when compared with the conventional single best answer (SBA) question …
View article: A novel role for myeloid endothelin-B receptors in hypertension
A novel role for myeloid endothelin-B receptors in hypertension Open
Mφ and ET-1 may play an important role in BP control and potentially have a critical role as a therapeutic target in hypertension.
View article: Variation in passing standards for graduation‐level knowledge items at <scp>UK</scp> medical schools
Variation in passing standards for graduation‐level knowledge items at <span>UK</span> medical schools Open
Objectives Given the absence of a common passing standard for students at UK medical schools, this paper compares independently set standards for common ‘one from five’ single‐best‐answer (multiple‐choice) items used in graduation‐level ap…
View article: Working with Commercially Available Quantum Dots for Immunofluorescence on Tissue Sections
Working with Commercially Available Quantum Dots for Immunofluorescence on Tissue Sections Open
Quantum dots are semiconductor fluorescent nanocrystals that exhibit excellent characteristics compared with more commonly used organic fluorescent dyes. For many years quantum dot conjugated products have been available in multiple forms …
View article: Choice of Illumination System & Fluorophore for Multiplex Immunofluorescence on FFPE Tissue Sections
Choice of Illumination System & Fluorophore for Multiplex Immunofluorescence on FFPE Tissue Sections Open
The recent availability of novel dyes and alternative light sources to facilitate complex tissue immunofluorescence studies such as multiplex labelling has not been matched by reports critically evaluating the considerations and relative b…
View article: Clinical Trial: Heme Arginate in patients planned for Cardiac Surgery (HACS)
Clinical Trial: Heme Arginate in patients planned for Cardiac Surgery (HACS) Open
Acute kidney injury (AKI) is a significant complication of cardiac surgery and is associated with increased morbidity and mortality [1]. Despite much research, there is no specific therapy available. Although AKI can be multifactorial, isc…
View article: Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes
Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes Open
Autoimmunity is associated with defective phagocytic clearance of apoptotic cells. IgM deficient mice exhibit an autoimmune phenotype consistent with a role for circulating IgM antibodies in apoptotic cell clearance. We have extensively ch…
View article: Hemin Preconditioning Upregulates Heme Oxygenase-1 in Deceased Donor Renal Transplant Recipients
Hemin Preconditioning Upregulates Heme Oxygenase-1 in Deceased Donor Renal Transplant Recipients Open
The primary outcome was achieved and demonstrated for the first time that HA safely induces HO-1 in transplant recipients. Planned larger studies will determine the impact of HO-1 upregulation on clinical outcomes and evaluate the benefit …