T. David Koster
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View article: Pneumothorax in Endobronchial Valve Therapy–Still a Lot to Be Learned
Pneumothorax in Endobronchial Valve Therapy–Still a Lot to Be Learned Open
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View article: Airway Scaffolds for Emphysema-related Hyperinflation: Six-Month Results from the BREATHE Trial
Airway Scaffolds for Emphysema-related Hyperinflation: Six-Month Results from the BREATHE Trial Open
Rationale: Despite advancements in emphysema treatment, high morbidity and mortality rates highlight the need for innovative therapies. A novel self-expanding nitinol airway scaffold was designed to alleviate lung hyperinflation by connect…
View article: Highlights from the 11th Bronchitis International Symposium: “Heterogeneity of Lung Disease in a Changing Environment,” Groningen, The Netherlands, 2024
Highlights from the 11th Bronchitis International Symposium: “Heterogeneity of Lung Disease in a Changing Environment,” Groningen, The Netherlands, 2024 Open
This meeting report provides an overview of the highlights of the Bronchitis XI international symposium, held in June 2024 in Groningen, The Netherlands. The theme of this year’s symposium was “heterogeneity of lung disease in a changing e…
View article: Lung Tensioning Device Coil Treatment in Patients with Severe Emphysema: A Prospective Safety and Feasibility Trial (EFFORT)
Lung Tensioning Device Coil Treatment in Patients with Severe Emphysema: A Prospective Safety and Feasibility Trial (EFFORT) Open
Introduction: Currently, there is a lack of bronchoscopic lung volume reduction options that do not depend on fissure integrity. Endobronchial coils have been extensively studied to address this need but exhibited variable patient response…
View article: Lung volume reduction surgery is safe and feasible after initial endobronchial valve treatment for emphysema patients
Lung volume reduction surgery is safe and feasible after initial endobronchial valve treatment for emphysema patients Open
OBJECTIVES Bronchoscopic lung volume reduction with endobronchial valves is a guideline treatment leading to improved pulmonary function, exercise tolerance and quality of life, in patients with advanced emphysema, severe hyperinflation an…
View article: Optimizing clinical outcomes for bronchoscopic lung volume reduction with Zephyr® valves
Optimizing clinical outcomes for bronchoscopic lung volume reduction with Zephyr® valves Open
Bronchoscopic lung volume reduction treatment with Zephyr one-way valves is an effective guideline-based treatment option for patients with severe emphysema and hyperinflation. However, in some cases the treatment response is less than ant…
View article: Bronchoscopic lung volume reduction treatment in severe COPD: from improving patient selection to management of complications
Bronchoscopic lung volume reduction treatment in severe COPD: from improving patient selection to management of complications Open
Chronic Obstructive Pulmonary Disease (COPD) is a common disease, often characterized by shortness of breath and coughing and this can lead to a poor quality of life. In patients with severe COPD, there can be hyperinflation and an increas…
View article: Response to endobronchial valve treatment: it's all about the target lobe
Response to endobronchial valve treatment: it's all about the target lobe Open
Background Bronchoscopic lung volume reduction using endobronchial valves (EBV) has been shown to be beneficial for severe emphysema patients. The most important predictor of treatment response is absence of collateral ventilation between …
View article: High-Resolution Computed Tomography-approximated Perfusion Is Comparable to Nuclear Perfusion Imaging in Severe Chronic Obstructive Pulmonary Disease
High-Resolution Computed Tomography-approximated Perfusion Is Comparable to Nuclear Perfusion Imaging in Severe Chronic Obstructive Pulmonary Disease Open
"HRCT-Approximated Perfusion is Comparable to Nuclear Perfusion Imaging in Severe COPD." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Impact of Endobronchial Valve Treatment on Lung Function Decline
Impact of Endobronchial Valve Treatment on Lung Function Decline Open
Introduction: Endobronchial valve (EBV) treatment has been shown to be beneficial for patients with severe emphysema. The forced expiratory volume in 1 s (FEV1) was found to be significantly higher compared to baseline for up to 3 years af…
View article: Bronchoscopic Lung Volume Reduction in Patients with Emphysema due to Alpha-1 Antitrypsin Deficiency
Bronchoscopic Lung Volume Reduction in Patients with Emphysema due to Alpha-1 Antitrypsin Deficiency Open
Background: Bronchoscopic lung volume reduction using one-way endobronchial valves (EBVs) is a valid therapy for severe emphysema patients. However, alpha-1 antitrypsin (AAT)-deficient patients were excluded from the majority of clinical t…
View article: Prevalence and Impact of COVID-19 among Severe COPD Patients post Bronchoscopic Lung Volume Reduction Treatment with Endobronchial Valves
Prevalence and Impact of COVID-19 among Severe COPD Patients post Bronchoscopic Lung Volume Reduction Treatment with Endobronchial Valves Open
Background: The COVID-19 pandemic has a great impact on numberless aspects of our society. In our bronchoscopic lung volume reduction interventional program, we work with severe COPD patients on a daily basis. Objectives: We were intereste…
View article: Long-term follow-up after bronchoscopic lung volume reduction valve treatment for emphysema
Long-term follow-up after bronchoscopic lung volume reduction valve treatment for emphysema Open
Background Multiple studies have shown that patients with severe emphysema can significantly benefit from bronchoscopic lung volume reduction endobronchial valve (EBV) treatment up to 1 year after treatment. However, hardly any data exist …
View article: A multicenter, prospective, single-arm clinical investigation of a modified staged treatment algorithm using the AeriSeal system - The STAGE trial
A multicenter, prospective, single-arm clinical investigation of a modified staged treatment algorithm using the AeriSeal system - The STAGE trial Open
The staged and lower dosed administration of AeriSeal does not impact the overall safety profile in terms of reducing the type and frequency of respiratory SAEs previously reported for a single-stage treatment. A larger volume of AeriSeal …
View article: Bronchoscopic Lung Volume Reduction for Emphysema: Review and Update
Bronchoscopic Lung Volume Reduction for Emphysema: Review and Update Open
In carefully selected patients with severe chronic obstructive pulmonary disease, characterized by emphysema and hyperinflation, lung volume reduction is an option to reduce lung hyperinflation, improve lung function, quality of life, and …
View article: 3D Fibrotic Lung Extracellular Matrix Hydrogels Trigger Pro-Fibrotic Responses in Primary Lung Fibroblasts
3D Fibrotic Lung Extracellular Matrix Hydrogels Trigger Pro-Fibrotic Responses in Primary Lung Fibroblasts Open
Idiopathic Pulmonary Fibrosis (IPF) is characterized by the aberrant deposition and organization of extracellular matrix (ECM). Increased stiffness of fibrotic lung tissue is a major contributor to fibrosis by perpetuating fibrotic respons…
View article: An adjusted and time-saving method to measure collateral ventilation with Chartis
An adjusted and time-saving method to measure collateral ventilation with Chartis Open
Introduction Bronchoscopic lung volume reduction with endobronchial valves is an important treatment option in selected patients with severe emphysema and absence of collateral ventilation in the treatment target lobe. The Chartis system p…
View article: Revision Bronchoscopy After Endobronchial Valve Treatment for Emphysema: Indications, Findings and Outcomes
Revision Bronchoscopy After Endobronchial Valve Treatment for Emphysema: Indications, Findings and Outcomes Open
Performing a revision bronchoscopy after EBV treatment is a useful procedure leading to an improved treatment effect in most patients. Granulation tissue formation, causing valve dysfunction, is the most common cause of longer term problem…
View article: Response to Endobronchial Valve Treatment in Emphysema Patients With Moderate Hyperinflation
Response to Endobronchial Valve Treatment in Emphysema Patients With Moderate Hyperinflation Open
Klooster, Karin PhD; Hartman, Jorine E. PhD; van Dijk, Marlies MD; Koster, Theodoor David MD; Slebos, Dirk-Jan MD, PhDAuthor Information
View article: Minimal important difference of change in patient-specific goals in severe emphysema patients
Minimal important difference of change in patient-specific goals in severe emphysema patients Open
Change in patient's personal treatment goals is an important patient-reported outcome and can be measured by the patient-specific complaints (PSC) questionnaire. This paper establishes the MID for this questionnaire as -5.9 points. https:/…
View article: Endobronchial valve therapy for severe emphysema: an overview of valve-related complications and its management
Endobronchial valve therapy for severe emphysema: an overview of valve-related complications and its management Open
Treating severe emphysema patients with one-way valves requires continuous dedication and expertise, especially to achieve an optimal outcome and elegantly deal with the various complications after treatment.
View article: Treatment of severe stable COPD: the multidimensional approach of treatable traits
Treatment of severe stable COPD: the multidimensional approach of treatable traits Open
Now that additional treatment options for severe chronic obstructive pulmonary disease (COPD) have emerged in recent years, patients with severe COPD should not be left in the rather hopeless situation of �there is nothing to improve� any …
View article: <p>An Integrative Approach of the Fissure Completeness Score and Chartis Assessment in Endobronchial Valve Treatment for Emphysema</p>
An Integrative Approach of the Fissure Completeness Score and Chartis Assessment in Endobronchial Valve Treatment for Emphysema Open
Quantitative CT analysis is recommended in all patients evaluated for endobronchial valves. Patients with incomplete fissures (left major fissure: FCS <80%; right major fissure: <90%) can be excluded from Chartis measurement and endobronch…
View article: Temporary Right Middle Lobe Occlusion with a Blocking Device to Enable Collateral Ventilation Measurement of the Right Major Fissure
Temporary Right Middle Lobe Occlusion with a Blocking Device to Enable Collateral Ventilation Measurement of the Right Major Fissure Open
Background: Absence of interlobar collateral ventilation is essential to achieve lobar volume reduction after endobronchial valve (EBV) treatment and can be assessed using the Chartis measurement. However, especially in lower lobe measurem…
View article: Supplementary Material for: Temporary Right Middle Lobe Occlusion with a Blocking Device to Enable Collateral Ventilation Measurement of the Right Major Fissure
Supplementary Material for: Temporary Right Middle Lobe Occlusion with a Blocking Device to Enable Collateral Ventilation Measurement of the Right Major Fissure Open
Background: Absence of interlobar collateral ventilation is essential to achieve lobar volume reduction after endobronchial valve (EBV) treatment and can be assessed using the Chartis measurement. However, especially in lower lobe measurem…