David L. Bolduc
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View article: Dosimetry Characterization and Early-Phase Dose and Injury-Severity Biomarkers in a Rhesus Macaque Dose-Response Model System
Dosimetry Characterization and Early-Phase Dose and Injury-Severity Biomarkers in a Rhesus Macaque Dose-Response Model System Open
The purpose of this study was to characterize radiation dosimetry and validate early-phase radiation biomarkers using a Rhesus macaque (Macaca mulatta) non-human-primate radiation model. Non-human-primates in pairs (male and females; 4.4 t…
View article: Severity scoring systems for radiation-induced GI injury – prioritization for use of GI-ARS medical countermeasures
Severity scoring systems for radiation-induced GI injury – prioritization for use of GI-ARS medical countermeasures Open
Severity scoring systems for ionizing radiation-induced gastrointestinal injury have been used in animal radiation models, human studies involving the use of radiation therapy, and human radiation accidents. Various radiation exposure scen…
View article: Captopril reduces lung inflammation and accelerated senescence in response to thoracic radiation in mice
Captopril reduces lung inflammation and accelerated senescence in response to thoracic radiation in mice Open
The lung is sensitive to radiation and exhibits several phases of injury, with an initial phase of radiation-induced pneumonitis followed by delayed and irreversible fibrosis. The angiotensin-converting enzyme inhibitor captopril has been …
View article: System for Scoring Severity of Acute Radiation Syndrome Response in Rhesus Macaques (<i>Macaca mulatta</i>)
System for Scoring Severity of Acute Radiation Syndrome Response in Rhesus Macaques (<i>Macaca mulatta</i>) Open
We developed a clinical assessment tool for use in an NHP radiation model to 1) quantify severity responses for subsyndromes of the acute radiation syndrome (ARS; that is, hematopoietic and others) and 2) identify animals that required enh…
View article: Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma
Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma Open
Exposure to ionizing radiation alone or combined with traumatic tissue injury is a crucial life-threatening factor in nuclear and radiological incidents. Radiation injuries occur at the molecular, cellular, tissue and systemic levels; thei…
View article: DEVELOPMENT OF PEDIATRIC MODEL OF HEMATOPOIETIC ACUTE RADIATION SYNDROME (H-ARS) AND COUNTERMEASURE TESTING USING THE GÖTTINGEN MINIPIG
DEVELOPMENT OF PEDIATRIC MODEL OF HEMATOPOIETIC ACUTE RADIATION SYNDROME (H-ARS) AND COUNTERMEASURE TESTING USING THE GÖTTINGEN MINIPIG Open
There is a pressing need to develop animal models as well as treatment appropriate for age-specific radiation injuries.The minipig represents a promising animal model for testing the effects of radiation on the pediatric population.We subj…
View article: MODELING H-ARS USING HEMATOLOGICAL PARAMETERS: A COMPARISON BETWEEN THE NON-HUMAN PRIMATE AND MINIPIG
MODELING H-ARS USING HEMATOLOGICAL PARAMETERS: A COMPARISON BETWEEN THE NON-HUMAN PRIMATE AND MINIPIG Open
Multiple hematological biomarkers (i.e. complete blood counts and serum chemistry parameters) were used in a multivariate linear-regression fit to create predictive algorithms for estimating the severity of hematopoietic acute radiation sy…
View article: Captopril Increases Survival after Whole-Body Ionizing Irradiation but Decreases Survival when Combined with Skin-Burn Trauma in Mice
Captopril Increases Survival after Whole-Body Ionizing Irradiation but Decreases Survival when Combined with Skin-Burn Trauma in Mice Open
Past and recent radiation events have involved a high incidence of radiation combined injury where victims often succumb to serious infections as a consequence of bacterial translocation and subsequent sepsis. The risk of infection is exac…
View article: Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice
Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice Open
Combination therapy eliminates infection and prolongs survival time but does not assure CI mouse survival, suggesting that additional treatment for proliferative-cell recovery is required.