David L. Cheung
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View article: Probing the Adsorption of Fibronectin onto Model Biomaterial Surfaces using Molecular Dynamics Simulations
Probing the Adsorption of Fibronectin onto Model Biomaterial Surfaces using Molecular Dynamics Simulations Open
Fibronectin is a versatile extracellular matrix glycoprotein, which fulfils many roles in cell adhesion and growth. Adsorption of fibronectin on biomaterial surfaces can influence the eventual biological fate of implanted medical devices o…
View article: Approach to management of bleeding during EUS-guided liver biopsy: salvage therapy using absorbable gelatin sponge
Approach to management of bleeding during EUS-guided liver biopsy: salvage therapy using absorbable gelatin sponge Open
View article: In silico investigations of albumin-GLP-1 receptor agonist complexes for diabetes drug delivery applications
In silico investigations of albumin-GLP-1 receptor agonist complexes for diabetes drug delivery applications Open
This paper describes the specific conformational folding patterns and residues involved in stabilizing the Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) peptide-albumin protein complex using molecular dynamic (MD) simulations and sur…
View article: Molecular dynamics simulation of fibronectin adsorption on peptoid brushes
Molecular dynamics simulation of fibronectin adsorption on peptoid brushes Open
In recent years there has been significant interest in the development of material surfaces that can control their interactions with proteins for mediating subsequent cell attachment. Such biointerfaces can have applications in e.g. medica…
View article: Surface Hydrophobicity Strongly Influences Adsorption and Conformation of Amyloid Beta Derived Peptides
Surface Hydrophobicity Strongly Influences Adsorption and Conformation of Amyloid Beta Derived Peptides Open
The formation of amyloid fibrils is a common feature of many protein systems. It has implications in both health, as amyloid fibrils are implicated in over 30 degenerative diseases, and in the biological functions of proteins. Surfaces hav…
View article: Aggregation of an Amyloidogenic Peptide on Gold Surfaces
Aggregation of an Amyloidogenic Peptide on Gold Surfaces Open
Solid surfaces have been shown to affect the aggregation and assembly of many biomolecular systems. One important example is the formation of protein fibrils, which can occur on a range of biological and synthetic surfaces. The rate of fib…
View article: Adsorption of Heparin-Binding Fragments of Fibronectin onto Hydrophobic Surfaces
Adsorption of Heparin-Binding Fragments of Fibronectin onto Hydrophobic Surfaces Open
Fibronectin is a multi-domain, extracellular matrix protein that plays a number of biological roles. As the adsorption of fibronectin onto the surface of implanted devices can lead to an inflammatory response or bacterial colonisation, und…
View article: Elucidation of microbial lignin degradation pathways using synthetic isotope-labelled lignin
Elucidation of microbial lignin degradation pathways using synthetic isotope-labelled lignin Open
Pathways by which the biopolymer lignin is broken down by soil microbes could be used to engineer new biocatalytic routes from lignin to renewable chemicals, but are currently not fully understood.
View article: Effect of Surface Hydrophobicity on the Adsorption of a Pilus-Derived Adhesin-like Peptide
Effect of Surface Hydrophobicity on the Adsorption of a Pilus-Derived Adhesin-like Peptide Open
Bacterial colonization of abiotic surfaces such as those of medical implants, membrane filters, and everyday household items is a process of tremendous importance for public health. Bacteria use adhesive cell surface structures called adhe…
View article: The Amyloidogenic Peptide Amyloid Beta(16–22) Displays Facet Dependent Conformation on Metal Surfaces
The Amyloidogenic Peptide Amyloid Beta(16–22) Displays Facet Dependent Conformation on Metal Surfaces Open
Currently, it is not understood how metal nanoparticles influence the formation of protein fibrils, although recent literature highlights that the shape and chemical composition of such nanoparticles can strongly influence the process. Und…
View article: The amyloidogenic peptide amyloid beta(16-22) displays facet dependent conformation on metal surfaces
The amyloidogenic peptide amyloid beta(16-22) displays facet dependent conformation on metal surfaces Open
Currently, it is not understood how metal nanoparticles influence the formation of protein fibrils, although recent literature highlights that the shape and chemical composition of such nanoparticles can strongly influence the process. Und…
View article: The amyloidogenic peptide amyloid beta(16-22) displays facet dependent conformation on metal surfaces
The amyloidogenic peptide amyloid beta(16-22) displays facet dependent conformation on metal surfaces Open
Currently, it is not understood how metal nanoparticles influence the formation of protein fibrils, although recent literature highlights that the shape and chemical composition of such nanoparticles can strongly influence the process. Und…
View article: Effect of the Air-Water Interface on the Conformation of Amyloid Beta
Effect of the Air-Water Interface on the Conformation of Amyloid Beta Open
Using MD simulation the conformation of the fibril forming protein amyloid beta at the air-water interface. It is found that adsorption at the air-water interface induces the formation of aggregation prone alpha-helical conformations, cons…
View article: Effect of the air–water interface on the conformation of amyloid beta
Effect of the air–water interface on the conformation of amyloid beta Open
It has long been recognized that liquid interfaces, such as the air–water interface (AWI), can enhance the formation of protein fibrils. This makes liquid interfaces attractive templates for fibril formation but fully realizing this requir…
View article: Effect of the Air-Water Interface on the Conformation of Amyloid Beta
Effect of the Air-Water Interface on the Conformation of Amyloid Beta Open
Using MD simulation the conformation of the fibril forming protein amyloid beta at the air-water interface. It is found that adsorption at the air-water interface induces the formation of aggregation prone alpha-helical conformations, cons…
View article: Effect of surface chemistry on islet amyloid polypeptide conformation
Effect of surface chemistry on islet amyloid polypeptide conformation Open
The formation of dense, linear arrays (fibrils) by biomolecules is the hallmark of a number of degenerative diseases, such as Alzheimer’s and type-2 diabetes. Protein fibrils have also attracted interest as building blocks for new material…
View article: Effect of Surface Chemistry on Islet Amyloid Polypeptide Conformation
Effect of Surface Chemistry on Islet Amyloid Polypeptide Conformation Open
The formation of dense, linear protein arrays (fibrils) is the hallmark of a number of degenerativediseases, such as Alzheimer’s and type-2 diabetes. Protein fibrils have also attracted interestas building blocks for new materials. It has …
View article: Effect of Surface Chemistry on IAPP Conformation
Effect of Surface Chemistry on IAPP Conformation Open
The formation of dense, linear protein arrays (fibrils) is the hallmark of a number of degenerativediseases, such as Alzheimer’s and type-2 diabetes. Protein fibrils have also attracted interestas building blocks for new materials. It has …
View article: Effect of Surface Structure on Peptide Adsorption on Soft Surfaces
Effect of Surface Structure on Peptide Adsorption on Soft Surfaces Open
Using molecular dynamics simulations the adsorption of peptides onto nanostructured surfaces, consisting of alternating hydrophilic-hydrophobic stripes, was investigated. The adsorption strength, calculated using metadynamics, was found to…
View article: Self-Assembly of Porphyrin Nanostructures at the Interface between Two Immiscible Liquids
Self-Assembly of Porphyrin Nanostructures at the Interface between Two Immiscible Liquids Open
One of the many evolved functions of photosynthetic organisms is to synthesize light harvesting nanostructures from photoactive molecules such as porphyrins. Engineering synthetic analogues with optimized molecular order necessary for the …
View article: Understanding and Controlling Food Protein Structure and Function in Foods: Perspectives from Experiments and Computer Simulations
Understanding and Controlling Food Protein Structure and Function in Foods: Perspectives from Experiments and Computer Simulations Open
The structure and interactions of proteins play a critical role in determining the quality attributes of many foods, beverages, and pharmaceutical products. Incorporating a multiscale understanding of the structure–function relationships o…
View article: Self-assembly of porphyrin nanostructures at the interface between two immiscible liquids
Self-assembly of porphyrin nanostructures at the interface between two immiscible liquids Open
One of the many evolved functions of photosynthetic organisms is to synthesize light harvesting nanostructures from photoactive molecules such as porphyrins. Engineering synthetic analogues with optimized molecular order necessary for the …
View article: Soft-Photoconversion Using Floating Self-Assembled Crystalline Films of Porphyrin Nanostructures
Soft-Photoconversion Using Floating Self-Assembled Crystalline Films of Porphyrin Nanostructures Open
One of many evolved functions of biological cell membranes is to induce and regulate self-assembly of photoactive molecules into efficient light harvesting nanomaterials. Synthetic molecular assemblies at soft interfaces exhibit macroscale…
View article: The Air-Water Interface Stabilises Alpha-Helical Conformations of the Insulin B-Chain
The Air-Water Interface Stabilises Alpha-Helical Conformations of the Insulin B-Chain Open
Using enhanced molecular dynamics simulations the structure of the insulin B-chain was investigated at the air-water interface and in bulk solution. Significant differences in the conformational behaviour between these environments were fo…
View article: The Air-Water Interface Stabilises Alpha-Helical Conformations of the Insulin B-Chain
The Air-Water Interface Stabilises Alpha-Helical Conformations of the Insulin B-Chain Open
Using enhanced molecular dynamics simulations the structure of the insulin B-chain was investigated at the air-water interface and in bulk solution. Significant differences in the conformational behaviour between these environments were fo…
View article: The Air-Water Interface Stabilises Alpha-Helical Conformations of the Insulin B-Chain
The Air-Water Interface Stabilises Alpha-Helical Conformations of the Insulin B-Chain Open
Using enhanced molecular dynamics simulations the structure of the insulin B-chain was investigated at the air-water interface and in bulk solution. Significant differences in the conformational behaviour between these environments were fo…
View article: Molecular Dynamics Simulation of Protein Biosurfactants
Molecular Dynamics Simulation of Protein Biosurfactants Open
Surfaces and interfaces are ubiquitous in nature and are involved in many biological processes. Due to this, natural organisms have evolved a number of methods to control interfacial and surface properties. Many of these methods involve th…
View article: Atomistic Study of Zwitterionic Peptoid Antifouling Brushes
Atomistic Study of Zwitterionic Peptoid Antifouling Brushes Open
Using molecular dynamics (MD) simulations, we study the molecular behavior and hydration properties of a set of zwitterionic "peptoid" brushes, grafted on a rutile surface, that has been previously reported to exhibit excellent resistance …
View article: Effect of Surface Structure on Peptide Adsorption on Soft Surfaces
Effect of Surface Structure on Peptide Adsorption on Soft Surfaces Open
Using molecular dynamics simulations the adsorption of peptides onto nanostructured surfaces, consisting of alternating hydrophilic-hydrophobic stripes, was investigated. The adsorption strength, calculated using metadynamics, was found to…
View article: Effect of Surface Structure on Peptide Adsorption on Soft Surfaces
Effect of Surface Structure on Peptide Adsorption on Soft Surfaces Open
Using molecular dynamics simulations the adsorption of peptides onto nanostructured surfaces, consisting of alternating hydrophilic-hydrophobic stripes, was investigated. The adsorption strength, calculated using metadynamics, was found to…