David LaRocca
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View article: Additional Cover
Additional Cover Open
Cover legend: The cover image is based on the article Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles by Tianpeng Zhang et al., https://doi.org/10.1111/acel.70071. [Image: see…
View article: Identification of Senomorphic <scp>miRNAs</scp> in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles
Identification of Senomorphic <span>miRNAs</span> in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles Open
Extracellular vesicles (EVs) are secreted by most cell types, transmitting crucial signaling molecules like proteins, small RNAs, and DNA. We previously demonstrated that EVs from murine and human mesenchymal stem cells (MSCs) functioned a…
View article: Exosomes derived from highly scalable and regenerative human progenitor cells promote functional improvement in a rat model of ischemic stroke
Exosomes derived from highly scalable and regenerative human progenitor cells promote functional improvement in a rat model of ischemic stroke Open
Globally, there are 15 million stroke patients each year who have significant neurological deficits. Today, there are no treatments that directly address these deficits. With demographics shifting to an older population, the problem is wor…
View article: Emerging Roles of Exosomes in Stroke Therapy
Emerging Roles of Exosomes in Stroke Therapy Open
Stroke is the number one cause of morbidity in the United States and number two cause of death worldwide. There is a critical unmet medical need for more effective treatments of ischemic stroke, and this need is increasing with the shift i…
View article: Emerging Roles of Exosomes in Stroke Therapy
Emerging Roles of Exosomes in Stroke Therapy Open
Stroke is the number one cause of morbidity in the United States and number two cause of death worldwide. There is a critical unmet medical need for more effective treatments of ischemic stroke, and this need is increasing with the shift i…
View article: Clonal and Scalable Endothelial Progenitor Cell Lines from Human Pluripotent Stem Cells
Clonal and Scalable Endothelial Progenitor Cell Lines from Human Pluripotent Stem Cells Open
Human pluripotent stem cells (hPSCs) can be used as a renewable source of endothelial cells for treating cardiovascular disease and other ischemic conditions. Here, we present the derivation and characterization of a panel of distinct clon…
View article: Clonal and Scalable Endothelial Progenitor Cell Lines from Human Pluripotent Stem Cells
Clonal and Scalable Endothelial Progenitor Cell Lines from Human Pluripotent Stem Cells Open
Human pluripotent stem cells (hPSCs) can be used as a renewable source of endothelial cells for treating cardiovascular disease and other ischemic conditions. Here, we present the derivation and characterization of a panel of distinct clon…
View article: Notes on Contributors
Notes on Contributors Open
Her research examines the politics, aesthetics, and ecologies of contemporary art through the lens of human waste, energy consumption and expenditure, and most recently, climate crisis and glacier melt in the circumpolar North.
View article: No Time to Age: Uncoupling Aging from Chronological Time
No Time to Age: Uncoupling Aging from Chronological Time Open
Multicellular life evolved from simple unicellular organisms that could replicate indefinitely, being essentially ageless. At this point, life split into two fundamentally different cell types: the immortal germline representing an unbroke…
View article: No Time to Age: Uncoupling Aging from Chronological Time
No Time to Age: Uncoupling Aging from Chronological Time Open
Multicellular life evolved from simple unicellular organisms that could replicate indefinitely being essentially ageless. At this point, life split into 2 fundamentally different cell types: the immortal germline representing an unbroken l…
View article: Differential Expression of α, β, and γ Protocadherin Isoforms During Differentiation, Aging, and Cancer
Differential Expression of α, β, and γ Protocadherin Isoforms During Differentiation, Aging, and Cancer Open
The cadherin family of cell surface glycoproteins plays a fundamental role in cell-cell recognition, thereby participating in diverse biological process such as embryonic morphogenesis and oncogenic transformation. The subset of clustered …
View article: Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells
Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells Open
Supercentenarians (≥110-year-old, SC) are a uniquely informative population not only because they surpass centenarians in age, but because they appear to age more slowly with fewer incidences of chronic age-related disease than centenarian…
View article: Toward a Unified Theory of Aging and Regeneration
Toward a Unified Theory of Aging and Regeneration Open
Growing evidence supports the antagonistic pleiotropy theory of mammalian aging. Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic-fetal transition, while provid…
View article: Acknowledgments
Acknowledgments Open
Thanking well is difficult work. And only someone who has attempted to convey thanks will know of the adversity one finds in trying to find (one’s own?) words of thanks. In an academic or we might say more broadly, bibliophilic context, th…
View article: Editorial Comment
Editorial Comment Open
A year has elapsed since Stanley Cavell died, and in that time those who knew him and read his work, have been coming to terms with his permanent departure. For many it has not been easy, and part of this difficulty includes trying to say …
View article: Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells
Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells Open
Taken together, these data demonstrate that self-renewing adipocyte progenitor cells can be derived from hES cells and that they are functionally like BAT cells but with unique properties that might be advantageous for basic research and f…
View article: Additional file 9: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells
Additional file 9: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells Open
Table S6. A non-targeted relative quantitative liquid chromatographyâ tandem mass spectrometry RP and HILIC)/MS/MS platform was used to capture 624 cell metabolites and 406 metabolites in their respective media at time of harvest. Data is …
View article: Additional file 6: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells
Additional file 6: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells Open
Table S3. Mitochondria quantitation data used in support of Additional file 3: Figure S1 (sheet 1) and ELISA data used in support of Fig. 3b (sheet 2) are shown. (XLSX 16 kb)
View article: Additional file 12: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells
Additional file 12: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells Open
Table S5. Illumina-based microarray data is presented for the expression of Illumina-based microarray mean values and standard deviation for the genes FABP4, UCP1, ADIPOQ, CITED1, LIPASIN, MYH3, HOXA5, and DLX5 in fBAT, SAT, NP88, NP110, a…
View article: Additional file 1: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells
Additional file 1: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells Open
Table S1. Illumina-based microarray data on expression levels of FABP4, UCP1, ADIPOQ, CITED1, LIPASIN, and MYH3, from control cells and 20 random hES cell-derived clonal embryonic progenitor cell lines differentiated for 14â days in (BMP4,…
View article: Additional file 7: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells
Additional file 7: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells Open
Table S4. Illumina-based microarray data is presented for normalized data on all gene expression (sheet 1), the calculation of mean values and standard deviation (sheet 2), the data used in support of Fig. 4 (sheet 3), the data used in sup…
View article: Additional file 2: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells
Additional file 2: of Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells Open
Table S2. Illumina-based microarray data on fBAT and SAT cells and the hES cell-derived clonal embryonic progenitor cell lines E85, E3, C4ELS5.1, C4ELS5.5, C4ELSR2, NP88, and NP110 in progenitor state (Ctrl) or differentiated for 14â days …
View article: Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression of <i>COX7A1</i> in embryonic and cancer cells
Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression of <i>COX7A1</i> in embryonic and cancer cells Open
Here we present the application of deep neural network (DNN) ensembles trained on transcriptomic data to identify the novel markers associated with the mammalian embryonic-fetal transition (EFT). Molecular markers of this process could pro…
View article: Translating Carlyle: Ruminating on the Models of Metafiction at the Emergence of an Emersonian Vernacular
Translating Carlyle: Ruminating on the Models of Metafiction at the Emergence of an Emersonian Vernacular Open
Given the exemplary studies of Thomas Carlyle’s influence on the Boston intelligentsia of the 1830s and 1840s, for instance by Robert D. Richardson and Barbara L. Packer, we may wonder if there are other questions to ask on the subject—and…
View article: Teaching Without Explication: Pedagogical Lessons from Rancière’s The Ignorant Schoolmaster in The Grand Budapest Hotel and The Emperor’s Club
Teaching Without Explication: Pedagogical Lessons from Rancière’s The Ignorant Schoolmaster in The Grand Budapest Hotel and The Emperor’s Club Open
How can one teach what one does not know? Most film depictions of teaching follow a satisfying (and it would seem endlessly entertaining) Aristotelian dramatic structure. But what if the teacher does not know what she is summoned to teach?…
View article: The Germline/Soma Dichotomy: Implications for Aging and Degenerative Disease
The Germline/Soma Dichotomy: Implications for Aging and Degenerative Disease Open
Human somatic cells are mortal due in large part to telomere shortening associated with cell division. Limited proliferative capacity may, in turn, limit response to injury and may play an important role in the etiology of age-related path…