David Leffers
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View article: Immunomodulatory Response of the Middle Ear Epithelial Cells in Otitis Media
Immunomodulatory Response of the Middle Ear Epithelial Cells in Otitis Media Open
Hypothesis The middle ear (ME) epithelium transforms because of changed immunomodulation during infection. Introduction The epithelial cells of the tympanic cavity represent the first line of defense in the context of otitis media. They ca…
View article: Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media
Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media Open
Hypothesis: Otitis media (OM) can be successfully visualized and diagnosed by dynamic microscopic optical coherence tomography (dmOCT). Background: OM is one of the most common infectious diseases and, according to the WHO, one of the lead…
View article: Effort-Reward Imbalance among otolaryngology residents in Germany
Effort-Reward Imbalance among otolaryngology residents in Germany Open
Introduction An increased psychosocial workload can have an negative impact on health. An effective way to record this is the effort reward imbalance model postulated by Siegrist. Values on this topic from ENT residents are missing, which …
View article: Complete response under pembrolizumab therapy
Complete response under pembrolizumab therapy Open
Background With the use of checkpoint inhibitors in the palliative setting of HNSCC, a therapy response up to a complete response could be achieved in individual cases.
View article: Immunomodulation as a Protective Strategy in Chronic Otitis Media
Immunomodulation as a Protective Strategy in Chronic Otitis Media Open
Introduction Major features of the pathogenesis in otitis media, the most common disease in childhood, include hyperplasia of the middle ear mucosa and infiltration by leukocytes, both of which typically resolve upon bacterial clearance vi…
View article: (Mammary analog) Secretory Carcinoma (MASC) of the salivary glands
(Mammary analog) Secretory Carcinoma (MASC) of the salivary glands Open
Background (Mammary analog) Secretory Carcinoma (MASC) is a new, very rare variant of malignant salivary gland diseases. It was first described in 2010 and included in the WHO classification in 2017. In 95% of the cases there is an ETV6-NT…
View article: Immunomodulation in Cholesteatoma
Immunomodulation in Cholesteatoma Open
Immunomodulation in Cholesteatoma Introduction The etiopathogenesis of chronic otitis media epitympanalis and its proliferative destructive course with possible complications such as destruction of bony structures with hearing loss, vestib…
View article: Survey on the need for an interactive e-Learning platform for ENT residents
Survey on the need for an interactive e-Learning platform for ENT residents Open
Objective Interactive - e-learning - platforms may replace the classical textbook in the future. Such media have the possible advantage of including video and audio files in a more comprehensive way, but ENT-specific platforms do not curre…
View article: Large cell neuroendocrine carcinoma of the nasopharynx
Large cell neuroendocrine carcinoma of the nasopharynx Open
Primary neuroendocrine tumors of the head and neck are a very rare entity. Poorly differentiated neuroendocrine carcinomas are highly aggressive tumors associated with a high propensity for recurrence, distant metastasis and poor survival …
View article: The thick tongue – a rare differential diagnosis
The thick tongue – a rare differential diagnosis Open
Amyloidosis manifests in up to 20% of the cases in head and neck. This leads to different symptoms depending on the affected tissue. The diagnosis is confirmed by histological detection of amyloid deposits in Congo red stain in a polarizin…