David Acuña
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View article: Lactate modulates TGF-β1– and IL-1β–induced transcriptional programs in human dermal fibroblasts: Potential implications for wound management
Lactate modulates TGF-β1– and IL-1β–induced transcriptional programs in human dermal fibroblasts: Potential implications for wound management Open
INTRODUCTION Cutaneous wounds are susceptible to metabolic imbalances, via hypoxia and the “Warburg effect,” which can lead to excessive lactate accumulation, potentially delaying healing. It is also accepted that lactylation of histones a…
View article: Hypoxia-Inducible Factor 1-alpha (HIF1α), Nicotinamide Adenine Dinucleotide (NAD+, NADH), and Nitric Oxide (NO) interplay in critically ill patients, with implications for patient safety and targeted therapies: a review
Hypoxia-Inducible Factor 1-alpha (HIF1α), Nicotinamide Adenine Dinucleotide (NAD+, NADH), and Nitric Oxide (NO) interplay in critically ill patients, with implications for patient safety and targeted therapies: a review Open
Background Critical illnesses such as sepsis, trauma, and multi-organ failure initiate complex molecular cascades that disrupt cellular homeostasis and contribute to poor outcomes. Key among these mediators are Nicotinamide Adenine Dinucle…
View article: Epidemiology, management, and outcomes of traumatic atlantooccipital dislocation: National registry study
Epidemiology, management, and outcomes of traumatic atlantooccipital dislocation: National registry study Open
Study design: National registry–based observational cohort study. Objective: This study describes the epidemiology, surgical management, and outcomes of traumatic atlantooccipital dislocation (AOD). Summary of background data: Traumatic AO…
View article: Predictors of surgical management and its impact on outcomes for combined C1–C2 fractures: National registry study
Predictors of surgical management and its impact on outcomes for combined C1–C2 fractures: National registry study Open
Introduction : Combined C1–C2 fractures are common upper cervical injuries with high morbidity and mortality. Controversy exists regarding which patients benefit from surgery because this is an understudied population with only class III e…
View article: Multicenter Study Examining Temporal Trends in Traumatic Intracranial Hemorrhage Over Six Years Using Joinpoint Regression
Multicenter Study Examining Temporal Trends in Traumatic Intracranial Hemorrhage Over Six Years Using Joinpoint Regression Open
The aging US population has altered the epidemiology of traumatic injury, but there are few studies examining changing patterns of traumatic intracranial hemorrhage (tICH). We examined temporal changes in incidence, demographics, severity,…
View article: The effect of circle of willis anatomy and scanning practices on outcomes for blunt cerebrovascular injuries
The effect of circle of willis anatomy and scanning practices on outcomes for blunt cerebrovascular injuries Open
Background Limited research has explored the effect of Circle of Willis (CoW) anatomy among blunt cerebrovascular injuries (BCVI) on outcomes. It remains unclear if current BCVI screening and scanning practices are sufficient in identifica…
View article: Hypoxia Dysregulates the Transcription of Myoendothelial Junction Proteins Involved with Nitric Oxide Production in Brain Endothelial Cells
Hypoxia Dysregulates the Transcription of Myoendothelial Junction Proteins Involved with Nitric Oxide Production in Brain Endothelial Cells Open
Myoendothelial junctions (MEJs) are structures that allow chemical signals to be transmitted between endothelial cells (ECs) and vascular smooth muscle cells, which control vascular tone. MEJs contain hemoglobin alpha (Hbα) and endothelial…
View article: Epidemiology of C2 fractures and determinants of surgical management: analysis of a national registry
Epidemiology of C2 fractures and determinants of surgical management: analysis of a national registry Open
Objective Operative management of axis fractures (C2) usually depend on the stability and location of the break and individual patient characteristics. We sought to describe the epidemiology of C2 fractures and hypothesized that determinan…
View article: A Pilot and Feasibility Study to Evaluate Small and Large Bite Fascial Closure Techniques
A Pilot and Feasibility Study to Evaluate Small and Large Bite Fascial Closure Techniques Open
Introduction. Few randomized controlled studies have been conducted comparing a small to large fascial bite technique, yet recommendations have been made to standardize small bite closures. However, large scale randomized controlled trials…
View article: Decreased adult trauma admission volumes and changing injury patterns during the COVID-19 pandemic at 85 trauma centers in a multistate healthcare system
Decreased adult trauma admission volumes and changing injury patterns during the COVID-19 pandemic at 85 trauma centers in a multistate healthcare system Open
Background Reports indicate social distancing guidelines and other effects of the COVID-19 pandemic impacted trauma patient volumes and injury patterns. This report is the first analysis of a large trauma network describing the extent of t…
View article: Predictors of splenic artery embolization as an adjunct to non-operative management of stable blunt splenic injury: a multi-institutional study
Predictors of splenic artery embolization as an adjunct to non-operative management of stable blunt splenic injury: a multi-institutional study Open
Background We sought to identify predictors of splenic artery embolization (SAE) over observation for hemodynamically stable patients with blunt splenic injury (BSI), by Organ Injury Scale (OIS) grade. Methods This was a multi-institutiona…
View article: Stress Hyperglycemia in Critically Ill Patients: Insight Into Possible Molecular Pathways
Stress Hyperglycemia in Critically Ill Patients: Insight Into Possible Molecular Pathways Open
Severe sepsis, systemic inflammatory response syndrome (SIRS), and traumatic brain injury are frequently associated with hyperglycemia in non-diabetic patients. In patients suffering from any of these conditions, hyperglycemia at admission…
View article: Undersea Constellations: The Global Biology of an Endangered Marine Megavertebrate Further Informed through Citizen Science
Undersea Constellations: The Global Biology of an Endangered Marine Megavertebrate Further Informed through Citizen Science Open
The whale shark is an ideal flagship species for citizen science projects because of its charismatic nature, its size, and the associated ecotourism ventures focusing on the species at numerous coastal aggregation sites. An online database…