David Lieb
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View article: 498 Integrated scRNAseq, TCR repertoire and spatial transcriptomic analysis reveals immune remodeling induced by combined BRAF/MEK/PD-1 inhibition in metastatic BRAFV600E colorectal cancer
498 Integrated scRNAseq, TCR repertoire and spatial transcriptomic analysis reveals immune remodeling induced by combined BRAF/MEK/PD-1 inhibition in metastatic BRAFV600E colorectal cancer Open
View article: Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis
Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis Open
View article: The immune cell landscape in kidneys of patients with lupus nephritis
The immune cell landscape in kidneys of patients with lupus nephritis Open
View article: Evaluation of a model-driven approach for the integration of robot operating system-based complex robot systems
Evaluation of a model-driven approach for the integration of robot operating system-based complex robot systems Open
In system development, integration is crucial—especially in domains like robotics, where the complexity of the applications makes it a particularly challenging task. The rapid growth in the sector can lead to the obsolescence of existing t…
View article: Multimodal blood based profiling reveals insights into mechanisms of immunotherapy resistance
Multimodal blood based profiling reveals insights into mechanisms of immunotherapy resistance Open
Many cancer patients treated with immune checkpoint blockade (ICB) do not have durable treatment responses. Circulating biomarkers have the potential to identify patients with primary resistance or early progression on therapy to alter tre…
View article: Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue Open
Rheumatoid arthritis (RA) is a complex immune-mediated inflammatory disorder in which patients suffer from inflammatory-erosive arthritis. Recent advances on histopathology heterogeneity of RA synovial tissue revealed three distinct phenot…
View article: Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis
Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis Open
Resident macrophages and infiltrating monocytes in kidneys of patients with lupus nephritis are altered both in frequency and function relative to their counterparts in healthy kidneys. The extent to which mouse models might be useful in d…
View article: Single-cell atlas of the liver myeloid compartment with cure of chronic viral hepatitis
Single-cell atlas of the liver myeloid compartment with cure of chronic viral hepatitis Open
Background/Aims Chronic viral infections present serious public health challenges. Direct-acting antivirals (DAAs) are now able to cure nearly all patients infected with the hepatitis C virus (HCV), representing the only cure of a human ch…
View article: Single-cell atlas of the liver myeloid compartment before and after cure of chronic viral hepatitis
Single-cell atlas of the liver myeloid compartment before and after cure of chronic viral hepatitis Open
View article: Cytotoxic CD4<sup>+</sup>T cells eliminate senescent cells by targeting cytomegalovirus antigen
Cytotoxic CD4<sup>+</sup>T cells eliminate senescent cells by targeting cytomegalovirus antigen Open
Senescent cell accumulation has been implicated in the pathogenesis of aging-associated diseases including cancer. The mechanism that prevents the accumulation of senescent cells in aging human organs is unclear. Here, we demonstrate that …
View article: Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial
Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial Open
While BRAF inhibitor combinations with EGFR and/or MEK inhibitors have improved clinical efficacy in BRAF V600E colorectal cancer (CRC), response rates remain low and lack durability. Preclinical data suggest that BRAF/MAPK pathway inhibit…
View article: Intrarenal Myeloid Subsets Associated with Kidney Injury are Comparable in Mice and Patients with Lupus Nephritis
Intrarenal Myeloid Subsets Associated with Kidney Injury are Comparable in Mice and Patients with Lupus Nephritis Open
View article: Plasma proteomic biomarkers identify non-responders and reveal biological insights about the tumor microenvironment in melanoma patients after PD1 blockade
Plasma proteomic biomarkers identify non-responders and reveal biological insights about the tumor microenvironment in melanoma patients after PD1 blockade Open
Most patients treated with immune checkpoint blockade (ICB) do not have durable treatment responses. Therefore, there is a critical need to identify early non-invasive biomarkers of response. We performed plasma proteomic analysis (>700 pr…
View article: Cytotoxic CD4 <sup>+</sup> T Cells Eliminate Senescent Cells by Targeting Commensal Cytomegalovirus Antigen
Cytotoxic CD4 <sup>+</sup> T Cells Eliminate Senescent Cells by Targeting Commensal Cytomegalovirus Antigen Open
View article: Systematic identification of genomic elements that regulate<i>FCGR2A</i>expression and harbor variants linked with autoimmune disease
Systematic identification of genomic elements that regulate<i>FCGR2A</i>expression and harbor variants linked with autoimmune disease Open
Background: FCGR2A binds antibody–antigen complexes to regulate the abundance of circulating and deposited complexes along with downstream immune and autoimmune responses. Although the abundance of FCRG2A may be critical in immune-mediated…
View article: Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial
Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial Open
View article: Spatially organized multicellular immune hubs in human colorectal cancer
Spatially organized multicellular immune hubs in human colorectal cancer Open
View article: Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory Open
View article: Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions Open
View article: Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions Open
View article: Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory Open
T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to improving immunotherapeutic modalities. Analysis of ant…
View article: Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses
Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses Open
Neoantigens sensitize melanomas to checkpoint blockade and trigger epitope spreading to self-antigens, a process mimicked by combination immunotherapy.
View article: Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer
Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer Open
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we tr…
View article: An efficient lentiviral CRISPRi approach to silence genes in primary human monocytes
An efficient lentiviral CRISPRi approach to silence genes in primary human monocytes Open
Human primary monocytes are critical in controlling immune responses and tissue homeostasis. However, to identify and study molecular components that underlie the function of these cells, there remains a need to develop methods to perturb …
View article: Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection Open
View article: Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients
Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients Open
Summary COVID-19 has caused over 1 million deaths globally, yet the cellular mechanisms underlying severe disease remain poorly understood. By analyzing several thousand plasma proteins in 306 COVID-19 patients and 78 symptomatic controls …
View article: Loss of the Nuclear Protein RTF2 Enhances Influenza Virus Replication
Loss of the Nuclear Protein RTF2 Enhances Influenza Virus Replication Open
Viral infection triggers the secretion of type I interferons, which in turn induce the expression of hundreds of antiviral genes. However, the roles of these induced genes in controlling viral infections remain largely unknown, limiting ou…
View article: Radiation Induced Checkpoint Immunotherapy Response in Refractory Colorectal and Pancreatic Adenocarcinoma
Radiation Induced Checkpoint Immunotherapy Response in Refractory Colorectal and Pancreatic Adenocarcinoma Open
Immune checkpoint blockade has limited efficacy in microsatellite stable (MSS) colorectal (CRC) and pancreatic (PDAC) cancer. Preclinical models have demonstrated the use of radiation to activate the innate immune response and stimulate re…
View article: Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection
Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection Open
The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein …
View article: Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages Open
Tumor-associated macrophages (TAM) are regulators of extracellular matrix (ECM) remodeling and metastatic progression, the main cause of cancer-associated death. We found that disabled homolog 2 mitogen-responsive phosphoprotein (DAB2) is …