David Liebl
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View article: BK Polyomavirus Infection of Bladder Microvascular Endothelial Cells Leads to the Activation of the cGAS‐STING Pathway
BK Polyomavirus Infection of Bladder Microvascular Endothelial Cells Leads to the Activation of the cGAS‐STING Pathway Open
BK polyomavirus (BKPyV) infection in humans is usually asymptomatic but ultimately results in viral persistence. In immunocompromised hosts, virus reactivation can lead to nephropathy or hemorrhagic cystitis. The urinary tract serves as a …
View article: Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications
Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications Open
In this study, spherical or hexagonal NaYF4:Yb,Er nanoparticles (UCNPs) with sizes of 25 nm (S-UCNPs) and 120 nm (L-UCNPs) were synthesized by high-temperature coprecipitation and subsequently modified with three kinds of polymers. These i…
View article: Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications
Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications Open
Spherical or hexagonal NaYF4:Yb,Er nanoparticles (UCNPs) with sizes of 25 nm (S-UCNPs) and 120 nm (L-UCNPs) were synthesized by high-temperature coprecipitation and subsequently modified with three kinds of polymers. These included poly(et…
View article: In-section Click-iT detection and super-resolution CLEM analysis of nucleolar ultrastructure and replication in plants
In-section Click-iT detection and super-resolution CLEM analysis of nucleolar ultrastructure and replication in plants Open
Correlative light and electron microscopy (CLEM) is an important tool for the localisation of target molecule(s) and their spatial correlation with the ultrastructural map of subcellular features at the nanometre scale. Adoption of these a…
View article: In-section Click-iT detection and super-resolution CLEM: Shedding light on nucleolar ultrastructure and S-phase progression in plants
In-section Click-iT detection and super-resolution CLEM: Shedding light on nucleolar ultrastructure and S-phase progression in plants Open
Correlative light and electron microscopy (CLEM) is an essential tool that allows for localisation of a particular target molecule(s) and their spatial correlation with the ultrastructural map of subcellular features at the nanometer scale…
View article: Desmosome dualism – most of the junction is stable, but a plakophilin moiety is persistently dynamic
Desmosome dualism – most of the junction is stable, but a plakophilin moiety is persistently dynamic Open
Desmosomes, strong cell–cell junctions of epithelia and cardiac muscle, link intermediate filaments to cell membranes and mechanically integrate cells across tissues, dissipating mechanical stress. They comprise five major protein classes …
View article: Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain
Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain Open
View article: Desmosomal dualism: the core is stable while plakophilin is dynamic
Desmosomal dualism: the core is stable while plakophilin is dynamic Open
Desmosomes, strong cell-cell junctions of epithelia and cardiac muscle, link intermediate filaments to cell membranes and mechanically integrate cells across tissues, dissipating mechanical stress. They comprise 5 major protein classes - d…
View article: Diversity and Function of Motile Ciliated Cell Types within Ependymal Lineages of the Zebrafish Brain
Diversity and Function of Motile Ciliated Cell Types within Ependymal Lineages of the Zebrafish Brain Open
Motile cilia defects impair cerebrospinal fluid (CSF) flow, and can cause brain and spine disorders. To date, the development of ciliated cells, their impact on CSF flow and their function in brain and axial morphogenesis are not fully und…
View article: Phase Transitions by an Abundant Protein in the Anammox Extracellular Matrix Mediate Cell-to-Cell Aggregation and Biofilm Formation
Phase Transitions by an Abundant Protein in the Anammox Extracellular Matrix Mediate Cell-to-Cell Aggregation and Biofilm Formation Open
By employing biophysical and liquid-liquid phase separation concepts, this study revealed how a highly abundant extracellular protein enhances the key environmental and industrial bioprocess of anaerobic ammonium oxidation (anammox). Extra…
View article: Heterochromatin loss as a determinant of progerin‐induced DNA damage in Hutchinson–Gilford Progeria
Heterochromatin loss as a determinant of progerin‐induced DNA damage in Hutchinson–Gilford Progeria Open
Hutchinson–Gilford progeria is a premature aging syndrome caused by a truncated form of lamin A called progerin. Progerin expression results in a variety of cellular defects including heterochromatin loss, DNA damage, impaired proliferatio…
View article: Baseplate Component TssK and Spatio-Temporal Assembly of T6SS in Pseudomonas aeruginosa
Baseplate Component TssK and Spatio-Temporal Assembly of T6SS in Pseudomonas aeruginosa Open
The Gram-negative bacteria use the contractile multi-molecular structure, called the Type VI Secretion System (T6SS) to inject toxic products into eukaryotic and prokaryotic cells. In this study, we use fluorescent protein fusions and time…
View article: Structural and Functional Characterization of the Type Three Secretion System (T3SS) Needle of Pseudomonas aeruginosa
Structural and Functional Characterization of the Type Three Secretion System (T3SS) Needle of Pseudomonas aeruginosa Open
The type three secretion system (T3SS) is a macromolecular protein nano-syringe used by different bacterial pathogens to inject effectors into host cells. The extracellular part of the syringe is a needle-like filament formed by the polyme…
View article: SopB-Mediated Recruitment of SNX18 Facilitates Salmonella Typhimurium Internalization by the Host Cell
SopB-Mediated Recruitment of SNX18 Facilitates Salmonella Typhimurium Internalization by the Host Cell Open
To invade epithelial cells, Salmonella enterica serovar Typhimurium (S. Typhimurium) induces macropinocytosis through the action of virulence proteins delivered across the host cell membrane via a type III secretion system. We show that af…
View article: CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses
CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses Open
It is well established that Ly6Chi monocytes develop from common monocyte progenitors (cMoPs) and reside in the bone marrow (BM) until they are mobilized into the circulation. In our study, we found that BM Ly6Chi monocytes are not a homog…
View article: <scp>PscI</scp> is a type <scp>III</scp> secretion needle anchoring protein with <i>in vitro</i> polymerization capacities
<span>PscI</span> is a type <span>III</span> secretion needle anchoring protein with <i>in vitro</i> polymerization capacities Open
Summary The export of bacterial toxins across the bacterial envelope requires the assembly of complex, membrane‐embedded protein architectures. P seudomonas aeruginosa employs type III secretion ( T 3 S ) injectisome to translocate exotoxi…