Logan A. Walsh
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View article: Obesity-associated checkpoint blockade sensitivity is regulated by the diet-microbiota-immunity axis 4468
Obesity-associated checkpoint blockade sensitivity is regulated by the diet-microbiota-immunity axis 4468 Open
Description Globally, more people are overweight/obese than underweight, and obesity is associated with increased risk and mortality of several types of cancer. Paradoxically, obesity is associated with improved immune checkpoint inhibitor…
Spatially mapping the tumour immune microenvironments of non-small cell lung cancer Open
Lung cancer is the leading cause of cancer-related deaths. An enhanced understanding of the immune microenvironments within these tumours may foster more precise and efficient treatment, particularly for immune-targeted therapies. The spat…
Policy Considerations of Open-Source Intelligence: A Study of Bellingcat's Online Investigation Patterns (2014-2024) Open
With the proliferation of social media and digital information tools, more and more internet users can participate in intelligence collection through open-source investigations – an area previously reserved for government agencies with acc…
View article: Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis
Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis Open
Objective Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but …
OS10.5.A MINIMALLY INVASIVE BRAIN METASTASES ARE CHARACTERIZED BY AN ACTIVE, ANTI-CANCER IMMUNE INFILTRATE Open
BACKGROUND Cancer metastasis to the brain is a common complication of advanced disease with limited therapeutic options. Although immune checkpoint inhibition has shown some efficacy in treating brain metastases (BrM), patient response is …
View article: Metabolic Stress Accelerates Dysregulated Synovial Macrophage-Fibroblast Communication and Htra1 Overproduction in Osteoarthritis
Metabolic Stress Accelerates Dysregulated Synovial Macrophage-Fibroblast Communication and Htra1 Overproduction in Osteoarthritis Open
Biomechanical and metabolic factors increase the risk for osteoarthritis (OA) by causing supraphysiological stresses on joint tissues. Chronic exposure to these stresses contributes to failure of the joint organ system, resulting in pain a…
Supplementary Data Legends from HER2∆16 Engages ENPP1 To Promote an Immune Cold Microenvironment in Breast Cancer Open
Legends for Supp. Figures S1-20
Supplementary Figures from HER2∆16 Engages ENPP1 To Promote an Immune Cold Microenvironment in Breast Cancer Open
Supp. Figures S1-20
Supplementary Data Legends from HER2∆16 Engages ENPP1 To Promote an Immune Cold Microenvironment in Breast Cancer Open
Legends for Supp. Figures S1-20
Data from HER2∆16 Engages ENPP1 To Promote an Immune Cold Microenvironment in Breast Cancer Open
The tumor immune microenvironment (TIME) is a critical determinant of therapeutic response. However, the mechanisms regulating its modulation are not fully understood. HER216, an oncogenic splice variant of the human epidermal growth fact…
Supplementary Figures from HER2∆16 Engages ENPP1 To Promote an Immune Cold Microenvironment in Breast Cancer Open
Supp. Figures S1-20
Spatial computational modelling illuminates the role of the tumour microenvironment for treating glioblastoma with immunotherapies Open
Glioblastoma is the most common and deadliest brain tumour in adults, with a median survival of 15 months under the current standard of care. Immunotherapies like immune checkpoint inhibitors and oncolytic viruses have been extensively stu…
View article: LGG-13. UNRAVELING THE SPATIAL TUMOR MICROENVIRONMENT OF PEDIATRIC LOW-GRADE GLIOMAS USING IMAGING MASS CYTOMETRY
LGG-13. UNRAVELING THE SPATIAL TUMOR MICROENVIRONMENT OF PEDIATRIC LOW-GRADE GLIOMAS USING IMAGING MASS CYTOMETRY Open
Pediatric low-grade gliomas (pLGG) are the most common brain tumors in children and are associated with significant morbidity. Therefore, there is an urgent need for novel therapeutic strategies. While some studies have described pLGG’s tu…
View article: Table S2 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Table S2 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of NSCLC cell lines with corresponding BRD4 mRNA levels and IC50 values for palbociclib.
View article: Table S3 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Table S3 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of common direct target genes of BRD4 in KRAS-mutant NSCLC cells.
View article: Supplementary Data from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Supplementary Data from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of supplementary data and Supplementary Figures 1-9.
View article: Supplementary Data from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Supplementary Data from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of supplementary data and Supplementary Figures 1-9.
View article: Table S1 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Table S1 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of top candidates identified from the cDNA screen.
View article: Table S4 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Table S4 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of genes related to cell cycle that are suppressed by BRD4 inhibition.
View article: Table S4 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Table S4 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of genes related to cell cycle that are suppressed by BRD4 inhibition.
View article: Table S2 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Table S2 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of NSCLC cell lines with corresponding BRD4 mRNA levels and IC50 values for palbociclib.
View article: Table S1 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Table S1 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of top candidates identified from the cDNA screen.
View article: Table S3 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Table S3 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of common direct target genes of BRD4 in KRAS-mutant NSCLC cells.
View article: Table S1 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Table S1 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of top candidates identified from the cDNA screen.
View article: Table S2 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Table S2 from Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer Open
List of NSCLC cell lines with corresponding BRD4 mRNA levels and IC50 values for palbociclib.