David Lübbering
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View article: Autoantigen‐selected B cells are bystanders in spontaneous T cell‐driven experimental autoimmune hepatitis
Autoantigen‐selected B cells are bystanders in spontaneous T cell‐driven experimental autoimmune hepatitis Open
Autoreactive B cells are considered pathogenic drivers in many autoimmune diseases; however, it is not clear whether autoimmune B cells are invariably pathogenic or whether they can also arise as bystanders of T cell‐driven autoimmune path…
View article: Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver
Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver Open
The liver is an immune-privileged organ that can deactivate autoreactive T cells. Yet in autoimmune hepatitis (AIH), autoreactive T cells can defy hepatic control and attack the liver. To elucidate how tolerance to self-antigens is lost du…