David M E Freeman
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View article: First in pregnancy continuous lactate monitoring using a minimally invasive microneedle device: a proof of concept study in healthy pregnant volunteers
First in pregnancy continuous lactate monitoring using a minimally invasive microneedle device: a proof of concept study in healthy pregnant volunteers Open
Objectives Validation and testing of a microneedle device capable of continuously monitoring lactate concentrations in healthy pregnant volunteers. Setting Clinical research facility in a Liverpool hospital in the UK. Participants Seven he…
View article: Advancing the management of maternal, fetal, and neonatal infection through harnessing digital health innovations
Advancing the management of maternal, fetal, and neonatal infection through harnessing digital health innovations Open
Infections occurring in the mother and neonate exert a substantial health burden worldwide. Optimising infection management is crucial for improving individual outcomes and reducing the incidence of antimicrobial resistance. Digital health…
View article: Wireless implantable bioelectronics with a direct electron transfer lactate enzyme for detection of surgical site infection in orthopaedics
Wireless implantable bioelectronics with a direct electron transfer lactate enzyme for detection of surgical site infection in orthopaedics Open
Periprosthetic infection is one of the most devastating complications following orthopaedic surgery. Rapid detection of an infection can change the treatment pathway and improve outcomes for the patient. In here, we propose a miniaturized …
View article: Continuous Measurement of Lactate Concentration in Human Subjects through Direct Electron Transfer from Enzymes to Microneedle Electrodes
Continuous Measurement of Lactate Concentration in Human Subjects through Direct Electron Transfer from Enzymes to Microneedle Electrodes Open
Microneedle lactate sensors may be used to continuously measure lactate concentration in the interstitial fluid in a minimally invasive and pain-free manner. First- and second-generation enzymatic sensors produce a redox-active product tha…
View article: A Perspective on microneedle sensor arrays for continuous monitoring of the body's chemistry
A Perspective on microneedle sensor arrays for continuous monitoring of the body's chemistry Open
Recent advances in the field of microneedle devices are having an impact on both diagnostic and therapeutic approaches to sustaining healthy populations globally. Whether this is for improving drug and vaccine efficacy or for continuous se…
View article: Real-time continuous measurement of lactate through a minimally invasive microneedle patch: a phase I clinical study
Real-time continuous measurement of lactate through a minimally invasive microneedle patch: a phase I clinical study Open
Introduction Determination of blood lactate levels supports decision-making in a range of medical conditions. Invasive blood-sampling and laboratory access are often required, and measurements provide a static profile at each instance. We …
View article: Real-time Continuous Measurement of Lactate through a Minimally-invasive Microneedle Biosensor: a Phase I Clinical Study
Real-time Continuous Measurement of Lactate through a Minimally-invasive Microneedle Biosensor: a Phase I Clinical Study Open
Introduction Determination of blood lactate levels supports decision-making in a range of medical conditions. Invasive blood-sampling and laboratory access are often required, and measurements provide a static profile at each instance. We …
View article: Microneedle biosensors for real-time, minimally invasive drug monitoring of phenoxymethylpenicillin: a first-in-human evaluation in healthy volunteers
Microneedle biosensors for real-time, minimally invasive drug monitoring of phenoxymethylpenicillin: a first-in-human evaluation in healthy volunteers Open
National Institute for Health Research Imperial Biomedical Research Centre, Mérieux Foundation.