David M. Lovinger
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View article: Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice
Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice Open
Background Ethanol metabolism is intimately linked with the physiological and behavioral aspects of ethanol consumption. Ethanol is mainly oxidized by alcohol dehydrogenase (ADH) to acetaldehyde and further to acetate via aldehyde dehydrog…
View article: A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments
A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments Open
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce the detection of effects because they condense within-trial signals into summary measures, and discard trial-leve…
View article: Impact of plastic sipper devices on alcohol self-administration in rodents: Limitations for long-term access paradigms
Impact of plastic sipper devices on alcohol self-administration in rodents: Limitations for long-term access paradigms Open
Open source devices are becoming widely used in behavioral neuroscience. Despite their advantages in cost effectiveness, modularity, and customization, measurements obtained using newly developed devices may not always recapitulate measure…
View article: Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice
Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice Open
Background Ethanol metabolism is intimately linked with the physiological and behavioral aspects of ethanol consumption. Ethanol is mainly oxidized by alcohol dehydrogenase (ADH) to acetaldehyde and further to acetate via aldehyde dehydrog…
View article: Ketone ester–enriched diet ameliorates motor and dopamine release deficits in MitoPark mice
Ketone ester–enriched diet ameliorates motor and dopamine release deficits in MitoPark mice Open
Parkinson's disease (PD) is a progressive, neurodegenerative disease characterized by motor dysfunction and dopamine deficits. The MitoPark (MP) mouse model of PD recapitulates several facets of Parkinson's disease, including gradual devel…
View article: A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments
A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments Open
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce detection of effects because they con dense within-trial signals into summary measures, and discard trial-level i…
View article: Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution
Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution Open
Functional deficits in basal ganglia (BG) circuits contribute to cognitive and motor dysfunctions in alcohol use disorder. Chronic alcohol exposure alters synaptic function and neuronal excitability in the dorsal striatum, but it remains u…
View article: Reviewer #1 (Public Review): A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments
Reviewer #1 (Public Review): A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments Open
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce detection of effects because they condense within-trial signals into summary measures, and discard trial-level in…
View article: A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments
A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments Open
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce the detection of effects because they condense within-trial signals into summary measures, and discard trial-leve…
View article: Author Response: A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments
Author Response: A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments Open
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce detection of effects because they condense within-trial signals into summary measures, and discard trial-level in…
View article: Reviewer #2 (Public Review): A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments
Reviewer #2 (Public Review): A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments Open
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce detection of effects because they condense within-trial signals into summary measures, and discard trial-level in…
View article: Reviewer #3 (Public Review): A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments
Reviewer #3 (Public Review): A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments Open
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce detection of effects because they condense within-trial signals into summary measures, and discard trial-level in…
View article: A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments
A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments Open
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce detection of effects because they condense within-trial signals into summary measures, and discard trial-level in…
View article: Motor cortex somatostatin interneurons adaptively shape the structure of action sequences
Motor cortex somatostatin interneurons adaptively shape the structure of action sequences Open
The brain can flexibly reorganize the structure of action sequence, or motor programs, to efficiently reach positive outcomes. These behavioral adaptations are primarily driven by reinforcement learning, leading to structural and kinematic…
View article: Chronic alcohol induces subcircuit-specific striatonigral plasticity shifting action control to the sensorimotor striatum
Chronic alcohol induces subcircuit-specific striatonigral plasticity shifting action control to the sensorimotor striatum Open
While cortico-striatal circuit deficits contribute to Alcohol Use Disorder, the impact of alcohol on synaptic function in the basal ganglia output, the substantia nigra pars reticulata (SNr), remains unclear. Here, we found that the inputs…
View article: A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments
A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments Open
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce detection of effects because they condense within-trial signals into summary measures, and discard trial-level in…
View article: Dopaminergic D2 receptor modulation of striatal cholinergic interneurons contributes to sequence learning
Dopaminergic D2 receptor modulation of striatal cholinergic interneurons contributes to sequence learning Open
Learning action sequences is necessary for normal daily activities. Medium spiny neurons (MSNs) in the dorsal striatum (dStr) encode action sequences through changes in firing at the start and/or stop of action sequences or sustained chang…
View article: Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring
Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring Open
Fetal Alcohol Spectrum Disorder (FASD) comprises a group of neurodevelopmental deficits caused by alcohol exposure during pregnancy. Clinical studies suggest that while the male progeny experiences serious neurodevelopmental defects, femal…