Jorge M. David
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View article: The Biflavonoid Agathisflavone Regulates Microglial and Astrocytic Inflammatory Profiles via Glucocorticoid Receptor
The Biflavonoid Agathisflavone Regulates Microglial and Astrocytic Inflammatory Profiles via Glucocorticoid Receptor Open
Nuclear receptors such as glucocorticoid receptors (GRs) are transcription factors with prominent regulatory effects on neuroinflammation. Agathisflavone is a biflavonoid that demonstrates neurogenic, neuroprotective, anti-inflammatory, an…
View article: The Flavonoid Agathisflavone Attenuates Glia Activation After Mechanical Injury of Cortical Tissue and Negatively Regulates Both NRLP3 and IL-1β Expression
The Flavonoid Agathisflavone Attenuates Glia Activation After Mechanical Injury of Cortical Tissue and Negatively Regulates Both NRLP3 and IL-1β Expression Open
Traumatic brain injury (TBI) has a complex and multifactorial pathology and is a major cause of death and disability for humans. Immediately after TBI, astrocytes and microglia react with complex morphological and functional changes known …
View article: Agathisflavone Inhibits Viability and Modulates the Expression of miR-125b, miR-155, IL-6, and Arginase in Glioblastoma Cells and Microglia/Macrophage Activation
Agathisflavone Inhibits Viability and Modulates the Expression of miR-125b, miR-155, IL-6, and Arginase in Glioblastoma Cells and Microglia/Macrophage Activation Open
Glioblastomas (GBM) are malignant tumours with poor prognosis. Treatment involves chemotherapy and/or radiotherapy; however, there is currently no standard treatment for recurrence, and prognosis remains unfavourable. Inflammatory mediator…
View article: RAIMUNDO BRAZ FILHO E SEUS 90 ANOS: MESTRE DA QUÍMICA DE PRODUTOS NATURAIS E INSPIRAÇÃO PARA AS FUTURAS GERAÇÕES
RAIMUNDO BRAZ FILHO E SEUS 90 ANOS: MESTRE DA QUÍMICA DE PRODUTOS NATURAIS E INSPIRAÇÃO PARA AS FUTURAS GERAÇÕES Open
View article: NOVIDADES EM QUÍMICA NOVA: ATUALIZAÇÕES NAS PRÁTICAS DE CIÊNCIA ABERTA E RENOVAÇÃO EDITORIAL
NOVIDADES EM QUÍMICA NOVA: ATUALIZAÇÕES NAS PRÁTICAS DE CIÊNCIA ABERTA E RENOVAÇÃO EDITORIAL Open
View article: A IMPORTÂNCIA DOS ARTIGOS DE REVISÃO NA CIÊNCIA: DADOS, TENDÊNCIAS E IMPACTO
A IMPORTÂNCIA DOS ARTIGOS DE REVISÃO NA CIÊNCIA: DADOS, TENDÊNCIAS E IMPACTO Open
View article: Neuroprotective Effect of Flavonoid Agathisflavone in the Ex Vivo Cerebellar Slice Neonatal Ischemia
Neuroprotective Effect of Flavonoid Agathisflavone in the Ex Vivo Cerebellar Slice Neonatal Ischemia Open
Agathisflavone is a flavonoid that exhibits anti-inflammatory and anti-oxidative properties. Here, we investigated the neuroprotective effects of agathisflavone on central nervous system (CNS) neurons and glia in the cerebellar slice ex vi…
View article: CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF EXTRACTS AND ISOLATED COMPOUNDS FROM THE ROOTS OF Bowdichia virgilioides (Fabaceae)
CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF EXTRACTS AND ISOLATED COMPOUNDS FROM THE ROOTS OF Bowdichia virgilioides (Fabaceae) Open
This study describes the chemical composition and biological activities of extracts and compounds obtained from the roots of Bowdichia virgilioides (Fabaceae). A mixture of very long-chain free fatty acids (VLFAs) and pure compounds, namel…
View article: The Phytochemical Agathisflavone Modulates miR146a and miR155 in Activated Microglia Involving STAT3 Signaling
The Phytochemical Agathisflavone Modulates miR146a and miR155 in Activated Microglia Involving STAT3 Signaling Open
MicroRNAs (miRs) act as important post-transcriptional regulators of gene expression in glial cells and have been shown to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD). Here, we investig…
View article: Hydroxytakakiamide and Other Constituents from a Marine Sponge-Associated Fungus Aspergillus fischeri MMERU23, and Antinociceptive Activity of Ergosterol Acetate, Acetylaszonalenin and Helvolic Acid
Hydroxytakakiamide and Other Constituents from a Marine Sponge-Associated Fungus Aspergillus fischeri MMERU23, and Antinociceptive Activity of Ergosterol Acetate, Acetylaszonalenin and Helvolic Acid Open
An unreported prenylated indole derivative hydroxytakakiamide (4) was isolated, together with the previously described ergosterol (1), ergosterol acetate (2), and (3R)-3-(1H-indol-3-ylmethyl)-3, 4-dihydro-1H-1,4-benzodiazepine-2,5-dione (3…
View article: Microwave extraction and molecular imprinted polymer isolation of bergenin applied to the dendrochronological chemical study of Peltophorum dubium
Microwave extraction and molecular imprinted polymer isolation of bergenin applied to the dendrochronological chemical study of Peltophorum dubium Open
This study describes methodologies for extracting and isolating bergenin, a C -glucoside of 4- O -methylgallic acid found in some plants and it presents various in vitro and in vivo biological activities. Bergenin was previously obtained f…
View article: PUBLICAÇÃO DE ARTIGOS CIENTÍFICOS E IA: UMA REVOLUÇÃO EM CURSO
PUBLICAÇÃO DE ARTIGOS CIENTÍFICOS E IA: UMA REVOLUÇÃO EM CURSO Open
View article: THE FLAVONOID AGATHISFLAVONE DIRECTS MICROGLIA TO AN ANTIOXIDANT AND ANTI-INFLAMMATORY STATUS VIA REGULATION OF NLRP3 INFLAMMASOME, THAT IS NEUROPROTECTIVE.
THE FLAVONOID AGATHISFLAVONE DIRECTS MICROGLIA TO AN ANTIOXIDANT AND ANTI-INFLAMMATORY STATUS VIA REGULATION OF NLRP3 INFLAMMASOME, THAT IS NEUROPROTECTIVE. Open
View article: CHEMICAL COMPOSITION, BIOLOGICAL ACTIVITIES AND USES OF ANACARDIACEAE SPECIES: AN UPDATED REVIEW
CHEMICAL COMPOSITION, BIOLOGICAL ACTIVITIES AND USES OF ANACARDIACEAE SPECIES: AN UPDATED REVIEW Open
The present review, with 169 references, describes a critical updated compilation of studies regarding the Anacardiaceae family. Firstly, it is shown a detailed report of the chemical composition (essential oils, terpenoids, flavonoids, al…
View article: CHEMICAL CONSTITUENTS AND ANTIBACTERIAL ACTIVITY OF THREE TYPES OF AMAZONIAN Melipona spp. GEOPROPOLIS
CHEMICAL CONSTITUENTS AND ANTIBACTERIAL ACTIVITY OF THREE TYPES OF AMAZONIAN Melipona spp. GEOPROPOLIS Open
This work describes the first chemical study on the metabolic profile of three geopropolis samples from Melipona fulva, M. compressipes, and M. paraensis collected in the Amazonian region. The samples were submitted to solvent extractions.…
View article: Green Tea Induces the Browning of Adipose Tissue—Systematic Review
Green Tea Induces the Browning of Adipose Tissue—Systematic Review Open
Several foods and nutrients are being studied extensively because they have a positive effect on thermogenesis and the browning of white adipose tissue. Therefore, this study aims to evaluate, through a systematic review, the effect of gre…
View article: The Flavonoid Agathisflavone Directs Brain Microglia/Macrophages to a Neuroprotective Anti-Inflammatory and Antioxidant State via Regulation of NLRP3 Inflammasome
The Flavonoid Agathisflavone Directs Brain Microglia/Macrophages to a Neuroprotective Anti-Inflammatory and Antioxidant State via Regulation of NLRP3 Inflammasome Open
Agathisflavone, purified from Cenostigma pyramidale (Tul.) has been shown to be neuroprotective in in vitro models of glutamate-induced excitotoxicity and inflammatory damage. However, the potential role of microglial regulation by agathis…
View article: Development of Methods Employing MAE for Extraction and Quantification of Triterpene Acids from Davilla Rugosa and Eriope Blanchetii
Development of Methods Employing MAE for Extraction and Quantification of Triterpene Acids from Davilla Rugosa and Eriope Blanchetii Open
View article: OS DESAFIOS ENFRENTADOS PELOS EDITORES DE PERIÓDICOS CIENTÍFICOS: PLÁGIO E PRODUÇÃO DE PESQUISA FALSA
OS DESAFIOS ENFRENTADOS PELOS EDITORES DE PERIÓDICOS CIENTÍFICOS: PLÁGIO E PRODUÇÃO DE PESQUISA FALSA Open
pesquisador está diretamente ligado à sua produção científica de qualidade.
View article: DESAFIOS SUPERADOS, NOVOS COMPROMISSOS
DESAFIOS SUPERADOS, NOVOS COMPROMISSOS Open
View article: PANORAMA ATUAL E PERSPECTIVAS PARA 2024
PANORAMA ATUAL E PERSPECTIVAS PARA 2024 Open
valor comparável à maioria dos periódicos de editoras internacionais.
View article: Phytochemical Characterization and Chemical Stability of Green Tea Extract
Phytochemical Characterization and Chemical Stability of Green Tea Extract Open
Camellia sinensis leaves tea has been one of the most consumed drinks in worldwide.Green tea has been consumed regularly by the world population, including for medicinal purposes.From a nutritional point of view, phytochemical analyzes is …
View article: Agathisflavone as a Single Therapy or in Association With Mesenchymal Stem Cells Improves Tissue Repair in a Spinal Cord Injury Model in Rats
Agathisflavone as a Single Therapy or in Association With Mesenchymal Stem Cells Improves Tissue Repair in a Spinal Cord Injury Model in Rats Open
Agathisflavone is a flavonoid with anti-neuroinflammatory and myelinogenic properties, being also capable to induce neurogenesis. This study evaluated the therapeutic effects of agathisflavone—both as a pharmacological therapy administered…
View article: The use of Curcuma longa and its Derivatives in the Treatment of Osteorthritis: A Scoping Review
The use of Curcuma longa and its Derivatives in the Treatment of Osteorthritis: A Scoping Review Open
Osteoarthritis is considered a degenerative disease, with knee and hip osteoarthritis being the most common form. Drug treatment is aimed at relieving symptoms with analgesics and non-selective or selective NSAIDs. Curcuma longa is a speci…
View article: Potential therapeutic effects of green tea on obese lipid profile – a systematic review
Potential therapeutic effects of green tea on obese lipid profile – a systematic review Open
Background: Green tea, obtained from the plant Camellis sinensis, is one of the oldest drinks in the world and contains numerous bioactive compounds. Studies have demonstrated the efficacy of green tea in preventing obesity and cardiovascu…
View article: PERSPECTIVAS PARA 2022
PERSPECTIVAS PARA 2022 Open
Para editores de revistas científicas, como a Química Nova, o início de cada ano é sempre um momento de reflexão, de se fazer um retrospecto, tanto em relação às dificuldades encontradas, como na comemoração dos avanços do ano anterior.
View article: METHODS FOR EXTRACTION AND ISOLATION OF AGATHISFLAVONE FROM Poincianella pyramidalis
METHODS FOR EXTRACTION AND ISOLATION OF AGATHISFLAVONE FROM Poincianella pyramidalis Open
Agathisflavone is a natural biflavone with restricted occurrence in plants. This biflavone presents several biological activities and can be important to developing new drugs. Obtaining such a molecule on a large scale for in vivo tests is…
View article: METHODS FOR EXTRACTION AND ISOLATION OF AGATHISFLAVONE FROM POINCIANELLA PYRAMIDALIS
METHODS FOR EXTRACTION AND ISOLATION OF AGATHISFLAVONE FROM POINCIANELLA PYRAMIDALIS Open
Agathisflavone is a natural biflavone with restricted occurrence in plants. This biflavone presents several biological activities and can be important to developing new drugs. Obtaining such a molecule on a large scale for in vivo tests is…
View article: What is new in non-chromatographic flavonoid purification?
What is new in non-chromatographic flavonoid purification? Open
Flavonoids are metabolites occurring in all plant tissues and present different biological activities. They occur in a mixture of similar polarity with laborious separation and purification processes, usually furnishing low yields. Semi-pr…
View article: QUÍMICA NOVA: TENDÊNCIAS, PERSPECTIVAS E NOVOS EDITORES
QUÍMICA NOVA: TENDÊNCIAS, PERSPECTIVAS E NOVOS EDITORES Open