David M Reck
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View article: Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2
Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2 Open
Polycomb Repressive Complex 2 (PRC2) is an essential chromatin regulator responsible for mono-, di- and tri-methylating H3K27. Control of PRC2 activity is a critical process in development and disease, yet no inhibitory cofactor has been i…
View article: A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells Open
Polycomb repressive complex 2 (PRC2), composed of the core subunits EED, SUZ12, and either EZH1 or EZH2, is critical for maintaining cellular identity in multicellular organisms. PRC2 deposits H3K27me3, which is thought to recruit the cano…