David M. Rothstein
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View article: PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition
PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition Open
Germinal-center (GC) B-cell responses are defined by many positive regulators of affinity maturation, but few components that restrain clonal dominance, notably Nr4a1 , are known. We reveal an unsuspected role for PRDM1 (BLIMP1), a plasma-…
View article: Donor-recipient mismatch at the <i>SIRPA</i> locus adversely affects kidney allograft outcomes
Donor-recipient mismatch at the <i>SIRPA</i> locus adversely affects kidney allograft outcomes Open
Donor-recipient mismatches in histocompatibility antigens recognized by lymphoid cells have been demonstrated to adversely affect allograft outcomes. In contrast, it remains unclear whether mismatches sensed by innate myeloid cells have a …
View article: B cell-derived IL-10 is an autocrine survival factor and maintains immune homeostasis in the spleen
B cell-derived IL-10 is an autocrine survival factor and maintains immune homeostasis in the spleen Open
IL-10 is a key anti-inflammatory cytokine and IL-10 KO mice develop colitis. Mice with a global IL-10 KO or constitutive B cell-specific IL-10 KO (CD19-Cre.IL-10fl/fl) have otherwise normal B cells. Surprisingly, we found that within 14-21…
View article: TIM-4 Identifies Effector B Cells Expressing a RORγt-Driven Proinflammatory Cytokine Module That Promotes Immune Responsiveness
TIM-4 Identifies Effector B Cells Expressing a RORγt-Driven Proinflammatory Cytokine Module That Promotes Immune Responsiveness Open
B cells can express pro-inflammatory cytokines that promote a wide variety of immune responses. Here we show that B cells expressing the phosphatidylserine receptor TIM-4, preferentially express IL-17A, as well as IL-22, IL-6, IL-1β, and G…
View article: Figures S1-S6 from Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy
Figures S1-S6 from Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy Open
GSK-3 inhibition effects on T-cells and anti-tumor responses
View article: Data from Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy
Data from Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy Open
The impact of PD-1 immune checkpoint therapy prompts exploration of other strategies to downregulate PD-1 for cancer therapy. We previously showed that the serine/threonine kinase, glycogen synthase kinase, GSK-3α/β, is a central regulator…
View article: Data from Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy
Data from Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy Open
The impact of PD-1 immune checkpoint therapy prompts exploration of other strategies to downregulate PD-1 for cancer therapy. We previously showed that the serine/threonine kinase, glycogen synthase kinase, GSK-3α/β, is a central regulator…
View article: Figures S1-S6 from Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy
Figures S1-S6 from Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy Open
GSK-3 inhibition effects on T-cells and anti-tumor responses
View article: Regulatory and transitional B cells: potential biomarkers and therapeutic targets in organ transplantation
Regulatory and transitional B cells: potential biomarkers and therapeutic targets in organ transplantation Open
Purpose of the review Regulatory B cells (Bregs) play a prominent role in various disease settings. While progress has been hindered by the lack of a specific Breg marker, new findings highlight their role modulating the alloimmune respons…
View article: B Cell IL-4 Drives Th2 Responses In Vivo, Ameliorates Allograft Rejection, and Promotes Allergic Airway Disease
B Cell IL-4 Drives Th2 Responses In Vivo, Ameliorates Allograft Rejection, and Promotes Allergic Airway Disease Open
B cells can be polarized to express various cytokines. The roles of IFNγ and IL-10, expressed respectively by B effector 1 (Be1) and Bregs, have been established in pathogen clearance, tumor growth, autoimmunity and allograft rejection. Ho…
View article: IL-17–dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10–producing B cells
IL-17–dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10–producing B cells Open
Prior experience of pathogen-associated stimuli reduces morbidity and mortality to newly encountered infections through innate immune training, which can be enhanced by childhood vaccination. Fibroblastic reticular cells (FRCs) are stromal…
View article: The Enzymatic Activity of Inosine 5′-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for <i>Staphylococcus aureus</i> Infections
The Enzymatic Activity of Inosine 5′-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for <i>Staphylococcus aureus</i> Infections Open
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5'-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial I…
View article: Petrographically Quantifying the Damage to Field and Lab-cast Mortars Subject to Freeze-thaw Cycles and Deicer Applications
Petrographically Quantifying the Damage to Field and Lab-cast Mortars Subject to Freeze-thaw Cycles and Deicer Applications Open
Although calcium oxychloride (Ca-Oxy) is known to damage cementitious materials exposed to calcium chloride (CaCl 2 ) deicers, there is little direct observation of Ca-Oxy in the field due to its instability. This paper uses optical micros…
View article: Regulatory B cells: TIM‐1, transplant tolerance, and rejection
Regulatory B cells: TIM‐1, transplant tolerance, and rejection Open
Regulatory B cells (Bregs) ameliorate autoimmune disease and prevent allograft rejection. Conversely, they hinder effective clearance of pathogens and malignancies. Breg activity is mainly attributed to IL‐10 expression, but also utilizes …
View article: CD45 ligation expands Tregs by promoting interactions with DCs
CD45 ligation expands Tregs by promoting interactions with DCs Open
Regulatory T cells (Tregs), which express CD4 and FOXP3, are critical for modulating the immune response and promoting immune tolerance. Consequently, methods to expand Tregs for therapeutic use are of great interest. While transfer of Tre…
View article: Microstructural Evaluation of Durability of Different Cementitious Mixtures in Microbial Induced Corrosion Environments
Microstructural Evaluation of Durability of Different Cementitious Mixtures in Microbial Induced Corrosion Environments Open
Sound and durable concrete mixtures are essential in environments where microbial induced corrosion (MIC) is a concern. In this study three concrete mixtures prepared with different binders (ordinary portland cement (OPC), calcium aluminat…
View article: ITS finally here! The first International Transplant Science meeting jointly organized by AST, ESOT, and TTS
ITS finally here! The first International Transplant Science meeting jointly organized by AST, ESOT, and TTS Open
The Transplantation Society (TTS) has had a long tradition of hosting a basic transplantation science meeting biannually since 1987. In fact, in 2017 TTS hosted its 15th Transplantation Science symposium in Vancouver, Canada. In the past, …
View article: In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease
In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease Open
Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (alloSCT). By static microscopy, cutaneous GVHD lesions contain a mix of T cells and myeloid cells. We used …
View article: Regulatory B cells and transplantation: almost prime time?
Regulatory B cells and transplantation: almost prime time? Open
Purpose of review Regulatory B cells (Bregs) are potent inhibitors of the immune system with the capacity to suppress autoimmune and alloimmune responses. Murine transplant models showing that Bregs can promote allograft tolerance are now …
View article: TIM-4 Identifies IFN-γ–Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection
TIM-4 Identifies IFN-γ–Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection Open
B cells give rise to polarized subsets, including B effector 1 (Be1) cells and regulatory B cells, which can promote or inhibit immune responses through expression of IFN-γ and IL-10, respectively. Such subsets likely explain why B cell de…
View article: The outstanding questions in transplantation: It’s about time…
The outstanding questions in transplantation: It’s about time… Open
To the Editor: Organ transplantation represents one of the most daring efforts of science and medicine to challenge end-stage organ diseases and ultimately death. This extraordinary gift of life would not have been possible without the ear…
View article: Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts
Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts Open
Detection of nonself SIRPα by CD47 triggers an innate immune response to allografts in mice that lack T, B, and NK cells.
View article: A Mutation in the Bacillus subtilis rsbU Gene That Limits RNA Synthesis during Sporulation
A Mutation in the Bacillus subtilis rsbU Gene That Limits RNA Synthesis during Sporulation Open
Mutants of Bacillis subtilis that are temperature sensitive for RNA synthesis during sporulation were isolated after selection with a 32 P suicide agent. Whole-genome sequencing revealed that two of the mutants carried an identical lesion …