David M. Selva
YOU?
Author Swipe
View article: Acute Downregulation of Zinc α2-Glycoprotein: Evidence from Human and HepG2 Cell Studies
Acute Downregulation of Zinc α2-Glycoprotein: Evidence from Human and HepG2 Cell Studies Open
Zinc-alpha2-glycoprotein (ZAG) is a soluble glycoprotein primarily produced in adipocytes and the liver, with key roles in lipid metabolism, including lipolysis and the browning of adipose tissue. Despite extensive studies on its role in r…
View article: Sex hormone-binding globulin, testosterone and type 2 diabetes risk in middle-aged African women: exploring the impact of HIV and menopause
Sex hormone-binding globulin, testosterone and type 2 diabetes risk in middle-aged African women: exploring the impact of HIV and menopause Open
Objectives Sex hormone-binding globulin (SHBG) and testosterone are differentially associated with type 2 diabetes (T2D) risk. We investigated whether these associations differ by HIV and menopausal status in Black South African women livi…
View article: Plasma SHBG Levels as an Early Predictor of Response to Bariatric Surgery
Plasma SHBG Levels as an Early Predictor of Response to Bariatric Surgery Open
Background Obesity is a growing global health problem, and currently, bariatric surgery (BS) is the best solution in terms of sustained total weight loss (TWL). However, a significant number of patients present weight regain (WR) in time. …
View article: When Sugar Reaches the Liver: Phenotypes of Patients with Diabetes and NAFLD
When Sugar Reaches the Liver: Phenotypes of Patients with Diabetes and NAFLD Open
Type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) have been traditionally linked to one another. Recent studies suggest that NAFLD may be increasingly common in other types of diabetes such as type 1 diabetes (T…
View article: Influence of Type 2 Diabetes in the Association of PNPLA3 rs738409 and TM6SF2 rs58542926 Polymorphisms in NASH Advanced Liver Fibrosis
Influence of Type 2 Diabetes in the Association of PNPLA3 rs738409 and TM6SF2 rs58542926 Polymorphisms in NASH Advanced Liver Fibrosis Open
Nonalcoholic steatohepatitis (NASH) is a leading cause of cirrhosis in western countries. Insulin resistance (IR), type 2 diabetes (T2D), and the polymorphisms patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 and transmembr…
View article: Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity
Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity Open
Background Sex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponect…
View article: Sex Hormone–Binding Globulin Expression Correlates With Acetyl-Coenzyme A Carboxylase and Triglyceride Content in Human Liver
Sex Hormone–Binding Globulin Expression Correlates With Acetyl-Coenzyme A Carboxylase and Triglyceride Content in Human Liver Open
Our findings suggest that SHBG plays a role in regulating hepatic lipogenesis by reducing ACC levels. These results suggest a strategy for the treatment of NAFLD.
View article: Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development
Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development Open
Low plasma sex hormone-binding globulin (SHBG) levels are a hallmark in chronic metabolic diseases, including nonalcoholic fatty liver disease (NAFLD), which represents a spectrum of disease ranging from hepatocellular steatosis through st…
View article: SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development
SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development Open
Low plasma sex hormone-binding globulin (SHBG) levels in overweight individuals are a biomarker for the metabolic syndrome and are predictive of type 2 diabetes and cardiovascular disease risk. There are no in vivo models to study SHBG exp…
View article: SHBG-C57BL/ksJ-db/db: a new mouse model to study the link between SHBG regulation and obesity development
SHBG-C57BL/ksJ-db/db: a new mouse model to study the link between SHBG regulation and obesity development Open
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)