Explanipedia

Neutrophil arrest in myocardial capillaries drives hypoxia and impairs diastolic function in a mouse model of heart failure with preserved ejection fraction Open

David M. Small, Anne E Buglione, Nathaniel H. Allan‐Rahill, T. J. Locke, Laila Abd Elmagid , et al. · 2025

Myocardial blood flow deficits in heart failure with preserved ejection fraction (HFpEF) patients and related animal models have been recognized for decades, but the underlying mechanisms and resulting consequences for HFpEF pathogenesis r…

Enhancing the Teaching of Research Ethics Through Emotional Priming with Encounters with Patients and Reflection Open

Ashley Earle, Nozomi Nishimura, Isaac Smith, David M. Small · 2024

Previous research has shown that the ability to consider the view of others impacted by actions is a major predictor for good ethical behavior. However, it is often hard to teach a student to understand the perspectives of impacted people …

Genetically engineered mice for combinatorial cardiovascular optobiology Open

Frank K. Lee, Jane C. Lee, Bo Shui, Shaun Reining, Megan Jibilian , et al. · 2021

Optogenetic effectors and sensors provide a novel real-time window into complex physiological processes, enabling determination of molecular signaling processes within functioning cellular networks. However, the combination of these optica…

Author response: Genetically engineered mice for combinatorial cardiovascular optobiology Open

Frank K. Lee, Jane C. Lee, Bo Shui, Shaun Reining, Megan Jibilian , et al. · 2021

Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Optogenetic effectors and sensors provide …

Genetically Engineered Mice for Combinatorial Cardiovascular Optobiology Open

Frank K. Lee, Jane C. Lee, Bo Shui, Shaun Reining, Megan Jibilian , et al. · 2021

Optogenetic effectors and sensors provide a novel real-time window into complex physiological processes, enabling determination of molecular signaling processes within functioning cellular networks. However, the combination of these optica…

Intravital Microscopy of the Beating Murine Heart to Understand Cardiac Leukocyte Dynamics Open

Nathaniel H. Allan‐Rahill, Michael R. E. Lamont, William M. Chilian, Nozomi Nishimura, David M. Small · 2020

Cardiovascular disease is the leading cause of worldwide mortality. Intravital microscopy has provided unprecedented insight into leukocyte biology by enabling the visualization of dynamic responses within living organ systems at the cell-…

An intravital window to image the colon in real time Open

Nikolai Rakhilin, Aliesha Garrett, C. John Eom, Katherine Ramos Chavez, David M. Small , et al. · 2019

Intravital microscopy is a powerful technique to observe dynamic processes with single-cell resolution in live animals. No intravital window has been developed for imaging the colon due to its anatomic location and motility, although the c…

Computed optical coherence microscopy of mouse brain ex vivo Open

Meiqi Wu, David M. Small, Nozomi Nishimura, Steven G. Adie · 2019

The compromise between lateral resolution and usable imaging depth range is a bottleneck for optical coherence tomography (OCT). Existing solutions for optical coherence microscopy (OCM) suffer from either large data size and long acquisit…

In Vivo Calcium Imaging of Cardiomyocytes in the Beating Mouse Heart With Multiphoton Microscopy Open

Jason S. Jones, David M. Small, Nozomi Nishimura · 2018

Background: Understanding the microscopic dynamics of the beating heart has been challenging due to the technical nature of imaging with micrometer resolution while the heart moves. The development of multiphoton microscopy has made…

Indoxyl Sulfate Induces Apoptosis and Hypertrophy in Human Kidney Proximal Tubular Cells Open

Robert J. Ellis, David M. Small, Keng Lim Ng, David A. Vesey, Luis Vitetta , et al. · 2018

Indoxyl sulfate (IS) is a protein-bound uremic toxin that accumulates in patients with declining kidney function. Although generally thought of as a consequence of declining kidney function, emerging evidence demonstrates direct cytotoxic …

In vivo multiphoton microscopy of cardiomyocyte calcium dynamics in the beating mouse heart Open

Jason S. Jones, David M. Small, Nozomi Nishimura · 2018

We demonstrated intravital multiphoton microscopy in the beating heart in an intact mouse and optically measured action potentials with GCaMP6f, a genetically-encoded calcium indicator. Images were acquired at 30 fps with spontaneous heart…

<i>N-</i>acetyl-cysteine increases cellular dysfunction in progressive chronic kidney damage after acute kidney injury by dampening endogenous antioxidant responses Open

David M. Small, Washington Y. Sanchez, Sandrine Roy, Christudas Morais, Heddwen L. Brooks , et al. · 2018

Oxidative stress and mitochondrial dysfunction exacerbate acute kidney injury (AKI), but their role in any associated progress to chronic kidney disease (CKD) remains unclear. Antioxidant therapies often benefit AKI, but their benefits in …

Label-free imaging of atherosclerotic plaques using third-harmonic generation microscopy Open

David M. Small, Jason S. Jones, Irwin I. Tendler, Paul E. Miller, Andre Ghetti , et al. · 2017

Multiphoton microscopy using laser sources in the mid-infrared range (MIR, 1,300 nm and 1,700 nm) was used to image atherosclerotic plaques from murine and human samples. Third harmonic generation (THG) from atherosclerotic plaques reveale…

Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease Open

David M. Small, Kassia S. Beetham, Erin J. Howden, David Briskey, David W. Johnson , et al. · 2017

Exercise and lifestyle modification in stage 3-4 CKD did not produce changes in systemic biomarkers of oxidative stress over a 12-month period, but patients with high IsoP may benefit most from the addition of intervention to standard care.

Simultaneous optical and electrical in vivo analysis of the enteric nervous system Open

Nikolai Rakhilin, Bradley B. Barth, Jiahn Choi, Nini Muñoz, Subhash Kulkarni , et al. · 2016

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