David M. Weller
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View article: Complete attenuation of Plasmodium falciparum sporozoites by atovaquone–proguanil
Complete attenuation of Plasmodium falciparum sporozoites by atovaquone–proguanil Open
To develop a Plasmodium falciparum (Pf) vaccine that precludes replication inside the host for improved vaccine safety, we tested chemo-attenuation (CVac) of sporozoites (SPZ) with atovaquone–proguanil (AP). In mice, P. berghei sporozoites…
View article: Role of viral coinfection in post-pandemic invasive Group A streptococcal infections in adults, a nation-wide cohort study (iGASWISS)
Role of viral coinfection in post-pandemic invasive Group A streptococcal infections in adults, a nation-wide cohort study (iGASWISS) Open
Objective During the winter season of 2022–2023, numerous countries experienced a surge in invasive Streptococcus pyogenes (iGAS) infections. The role of viral coinfections in the post-COVID surge has not been elucidated. We report nation-…
View article: Impact of the COVID-19 Pandemic on Group A Streptococcal Necrotizing Soft Tissue Infections: A Retrospective Cohort Study
Impact of the COVID-19 Pandemic on Group A Streptococcal Necrotizing Soft Tissue Infections: A Retrospective Cohort Study Open
Background Necrotizing soft tissue infections (NSTIs) are often caused by group A Streptococcus (GAS). As the number of invasive GAS infections decreased during the coronavirus disease 2019 (COVID-19) pandemic restrictions, this study aime…
View article: Cross-sectional associations between prenatal maternal per-/poly-fluoroalkyl substances (PFAS) and bioactive lipids in three Environmental influences on Child Health Outcomes cohorts
Cross-sectional associations between prenatal maternal per-/poly-fluoroalkyl substances (PFAS) and bioactive lipids in three Environmental influences on Child Health Outcomes cohorts Open
View article: Plant-Driven Assembly of Disease-Suppressive Soil Microbiomes
Plant-Driven Assembly of Disease-Suppressive Soil Microbiomes Open
Plants have coevolved together with the microbes that surround them and this assemblage of host and microbes functions as a discrete ecological unit called a holobiont. This review outlines plant-driven assembly of disease-suppressive micr…
View article: Disease-Suppressive Soils Induce Systemic Resistance in <i>Arabidopsis thaliana</i> Against <i>Pseudomonas syringae</i> pv. <i>tomato</i>
Disease-Suppressive Soils Induce Systemic Resistance in <i>Arabidopsis thaliana</i> Against <i>Pseudomonas syringae</i> pv. <i>tomato</i> Open
Arabidopsis thaliana accession Col-0 seedlings were transferred into an autoclaved soil/sand mixture amended with either 10 or 20% (wt/wt) soil from fields in Washington State that are suppressive to take-all or Rhizoctonia root rot of whe…
View article: Cross-sectional associations between prenatal maternal per- and poly-fluoroalkyl substances and bioactive lipids in three Environmental influences on Child Health Outcomes (ECHO) cohorts
Cross-sectional associations between prenatal maternal per- and poly-fluoroalkyl substances and bioactive lipids in three Environmental influences on Child Health Outcomes (ECHO) cohorts Open
Background Per- and poly-fluoroalkyl substances (PFAS) exposure can occur through ingestion of contaminated food and water, and inhalation of indoor air contaminated with these chemicals from consumer and industrial products. Prenatal PFAS…
View article: Eight Years in the Soil: Temporal Dynamics of Wheat-Associated Bacterial Communities Under Dryland and Irrigated Conditions
Eight Years in the Soil: Temporal Dynamics of Wheat-Associated Bacterial Communities Under Dryland and Irrigated Conditions Open
View article: Glutamic acid reshapes the plant microbiota to protect plants against pathogens
Glutamic acid reshapes the plant microbiota to protect plants against pathogens Open
View article: Development of platforms for functional characterization and production of phenazines using a multi-chassis approach via CRAGE
Development of platforms for functional characterization and production of phenazines using a multi-chassis approach via CRAGE Open
View article: Root Exudates Alter the Expression of Diverse Metabolic, Transport, Regulatory, and Stress Response Genes in Rhizosphere Pseudomonas
Root Exudates Alter the Expression of Diverse Metabolic, Transport, Regulatory, and Stress Response Genes in Rhizosphere Pseudomonas Open
Plants live in association with microorganisms that positively influence plant development, vigor, and fitness in response to pathogens and abiotic stressors. The bulk of the plant microbiome is concentrated belowground at the plant root-s…
View article: The effect of root exudates on the transcriptome of rhizosphere<i>Pseudomonas</i>spp
The effect of root exudates on the transcriptome of rhizosphere<i>Pseudomonas</i>spp Open
Plants live in association with microorganisms that positively influence plant development, vigor, and fitness in response to pathogens and abiotic stressors. The bulk of the plant microbiome is concentrated belowground at the plant root-s…
View article: Additional file 4 of Glutamic acid reshapes the plant microbiota to protect plants against pathogens
Additional file 4 of Glutamic acid reshapes the plant microbiota to protect plants against pathogens Open
Additional file 3. Strawberry anthosphere metagenome OTU data.
View article: Additional file 5 of Glutamic acid reshapes the plant microbiota to protect plants against pathogens
Additional file 5 of Glutamic acid reshapes the plant microbiota to protect plants against pathogens Open
Additional file 4. Tomato rhizosphere metagenome OTU data.
View article: Glutamic Acid Reshapes The Phytobiome To Protect Plants Against Pathogens
Glutamic Acid Reshapes The Phytobiome To Protect Plants Against Pathogens Open
Background: The physiology and growth of plants are strongly influenced by their associated microbiomes. Conversely, the composition of the phytobiome is flexible, responding to the state of the host and raising the possibility that it can…
View article: Mapping of safe and early chemo-attenuated live<i>Plasmodium falciparum</i>immunization identifies immune signature of vaccine efficacy
Mapping of safe and early chemo-attenuated live<i>Plasmodium falciparum</i>immunization identifies immune signature of vaccine efficacy Open
Potent protection against malaria can be induced by attenuated live-immunization with Plasmodium falciparum (Pf) sporozoites (SPZ). However, a better understanding of the critical processes involved in the establishment of protective immun…
View article: Consumer behavior and exposure to parabens, bisphenols, triclosan, dichlorophenols, and benzophenone-3: Results from a crowdsourced biomonitoring study
Consumer behavior and exposure to parabens, bisphenols, triclosan, dichlorophenols, and benzophenone-3: Results from a crowdsourced biomonitoring study Open
Nearly all Americans have detectable concentrations of endocrine disrupting chemicals from consumer products in their bodies, and expert panels recommend reducing exposures. To inform exposure reduction, we investigated whether consumers w…
View article: Author response: Global landscape of phenazine biosynthesis and biodegradation reveals species-specific colonization patterns in agricultural soils and crop microbiomes
Author response: Global landscape of phenazine biosynthesis and biodegradation reveals species-specific colonization patterns in agricultural soils and crop microbiomes Open
View article: Genome-Wide Identification and Expression Profile Analysis of the Phospholipase C Gene Family in Wheat (Triticum aestivum L.)
Genome-Wide Identification and Expression Profile Analysis of the Phospholipase C Gene Family in Wheat (Triticum aestivum L.) Open
Phospholipid-hydrolyzing enzymes include members of the phospholipase C (PLC) family that play important roles in regulating plant growth and responding to stress. In the present study, a systematic in silico analysis of the wheat PLC gene…
View article: Global landscape of phenazine biosynthesis and biodegradation reveals species-specific colonization patterns in agricultural soils and crop microbiomes
Global landscape of phenazine biosynthesis and biodegradation reveals species-specific colonization patterns in agricultural soils and crop microbiomes Open
Phenazines are natural bacterial antibiotics that can protect crops from disease. However, for most crops it is unknown which producers and specific phenazines are ecologically relevant, and whether phenazine biodegradation can counter the…
View article: <i>Pseudomonas synxantha</i> 2-79 Transformed with Pyrrolnitrin Biosynthesis Genes Has Improved Biocontrol Activity Against Soilborne Pathogens of Wheat and Canola
<i>Pseudomonas synxantha</i> 2-79 Transformed with Pyrrolnitrin Biosynthesis Genes Has Improved Biocontrol Activity Against Soilborne Pathogens of Wheat and Canola Open
A four-gene operon (prnABCD) from Pseudomonas protegens Pf-5 encoding the biosynthesis of the antibiotic pyrronitrin was introduced into P. synxantha (formerly P. fluorescens) 2-79, an aggressive root colonizer of both dryland and irrigate…
View article: A mutualistic interaction between Streptomyces bacteria, strawberry plants and pollinating bees
A mutualistic interaction between Streptomyces bacteria, strawberry plants and pollinating bees Open
View article: Exploring the Pathogenicity of <i>Pseudomonas brassicacearum</i> Q8r1-96 and Other Strains of the <i>Pseudomonas fluorescens</i> Complex on Tomato
Exploring the Pathogenicity of <i>Pseudomonas brassicacearum</i> Q8r1-96 and Other Strains of the <i>Pseudomonas fluorescens</i> Complex on Tomato Open
Pseudomonas brassicacearum and related species of the P. fluorescens complex have long been studied as biocontrol and growth-promoting rhizobacteria involved in suppression of soilborne pathogens. We report here that P. brassicacearum Q8r1…
View article: Soil Probiotic Utilizes Plant and Pollinator Transport for Territorial Expansion
Soil Probiotic Utilizes Plant and Pollinator Transport for Territorial Expansion Open
Microbe-plant interactions are linked with the core microbiota, and both the plant and the microbial partners depend on one other to thrive in nature. However, why and how the below-ground core microbiota become established aboveground is …
View article: The soil‐borne legacy in the age of the holobiont
The soil‐borne legacy in the age of the holobiont Open
Future efforts to increase agricultural productivity will focus on crops as functional units comprised of plants and their associated microflora in the context of the various environments in which they are grown. It is suggested that futur…
View article: Differential Response of Wheat Cultivars to<i>Pseudomonas brassicacearum</i>and Take-All Decline Soil
Differential Response of Wheat Cultivars to<i>Pseudomonas brassicacearum</i>and Take-All Decline Soil Open
2,4-Diacetylphloroglucinol (DAPG)-producing Pseudomonas spp. in the P. fluorescens complex are primarily responsible for a natural suppression of take-all of wheat known as take-all decline (TAD) in many fields in the United States. P. bra…
View article: An integrated workflow for phenazine-modifying enzyme characterization
An integrated workflow for phenazine-modifying enzyme characterization Open
Increasing availability of new genomes and putative biosynthetic gene clusters (BGCs) has extended the opportunity to access novel chemical diversity for agriculture, medicine, environmental and industrial purposes. However, functional cha…
View article: Multiple Modes of Nematode Control by Volatiles of Pseudomonas putida 1A00316 from Antarctic Soil against Meloidogyne incognita
Multiple Modes of Nematode Control by Volatiles of Pseudomonas putida 1A00316 from Antarctic Soil against Meloidogyne incognita Open
Pseudomonas putida 1A00316 isolated from Antarctic soil showed nematicidal potential for biological control of Meloidogyne incognita; however, little was known about whether strain 1A00316 could produce volatile organic compo…
View article: Biological Control of <i>Botrytis cinerea</i>: Interactions with Native Vineyard Yeasts from Washington State
Biological Control of <i>Botrytis cinerea</i>: Interactions with Native Vineyard Yeasts from Washington State Open
Native yeasts are of increasing interest to researchers, grape growers, and vintners because of their potential for biocontrol activity and their contributions to the aroma, flavor, and mouthfeel qualities of wines. To assess biocontrol ac…
View article: Volatile organic compounds from Paenibacillus polymyxa KM2501-1 control Meloidogyne incognita by multiple strategies
Volatile organic compounds from Paenibacillus polymyxa KM2501-1 control Meloidogyne incognita by multiple strategies Open