David Maresca
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View article: A Compact 2-D Matrix Array Comprised of Hexagonal Transducer Elements for Fast Volumetric Ultrasound Imaging
A Compact 2-D Matrix Array Comprised of Hexagonal Transducer Elements for Fast Volumetric Ultrasound Imaging Open
Advances in 4-D ultrasound imaging open new perspectives in biomedical research by reducing the long-standing challenge of operator dependency. Extensive research efforts are focused on developing next generation of 2-D transducer arrays f…
View article: Adaptive transcranial ultrasound Doppler imaging of the brain
Adaptive transcranial ultrasound Doppler imaging of the brain Open
The development of fully noninvasive, transcranial functional ultrasound (fUS) would increase the translatability and clinical potential of this neuroimaging modality. Unfortunately, transcranial fUS is hindered by skull-induced aberration…
View article: Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale
Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale Open
Light-sheet fluorescence microscopy has revolutionized biology by visualizing dynamic cellular processes in three dimensions. However, light scattering in thick tissue and photobleaching of fluorescent reporters limit this method to studyi…
View article: A Low-Cost Photobioreactor for Scalable Gas Vesicle Production
A Low-Cost Photobioreactor for Scalable Gas Vesicle Production Open
Gas vesicles (GVs) are air-filled protein nanostructures (∼85 nm diameter, ∼500 nm length) with the physical property to scatter sound. This new class of contrast agent serves as an acoustic analog to green fluorescent proteins and enables…
View article: Cross amplitude modulation imaging: theory and basic principles
Cross amplitude modulation imaging: theory and basic principles Open
The introduction of genetically encoded gas vesicles (GVs), protein nanostructures with the ability to scatter sound, has created the possibility for deep tissue cellular imaging. GVs establish a platform for biomolecular engineering and w…
View article: Bridging Neuroscience and Engineering with Nano-Neurotechnology
Bridging Neuroscience and Engineering with Nano-Neurotechnology Open
View article: Assessing Transducer Parameters for Accurate Medium Sound Speed Estimation and Image Reconstruction
Assessing Transducer Parameters for Accurate Medium Sound Speed Estimation and Image Reconstruction Open
The influence of the transducer lens on image reconstruction is often overlooked. Lenses usually exhibit a lower sound speed than soft biological tissues. In academic research, the exact lens sound speed and thickness are typically unknown…
View article: Nonlinear sound-sheet microscopy: imaging opaque organs at the capillary and cellular scale
Nonlinear sound-sheet microscopy: imaging opaque organs at the capillary and cellular scale Open
Light-sheet fluorescence microscopy has revolutionized biology by visualizing dynamic cellular processes in three dimensions. However, light scattering in thick tissue and photobleaching of fluorescent reporters limit this method to studyi…
View article: Impact of wavefront shape on nonlinear ultrasound imaging of monodisperse microbubbles
Impact of wavefront shape on nonlinear ultrasound imaging of monodisperse microbubbles Open
The field of contrast-enhanced ultrasound (CEUS) combines nonlinear, resonant microbubbles (MBs) with dedicated pulse sequences to reveal the vascular function of organs. Clinical ultrasound contrast agents consist of polydisperse MB suspe…
View article: CFD models for the PROTEUS simulator
CFD models for the PROTEUS simulator Open
This archive file contains the CFD simulation files and corresponding models to use with the PROTEUS simulator. You can download the model of your choice, unzip it, and place it in the "geometry_data" folder of the PROTEUS simulator. You m…
View article: CFD models for the PROTEUS simulator
CFD models for the PROTEUS simulator Open
This archive file contains the CFD simulation files and corresponding models to use with the PROTEUS simulator. You can download the model of your choice, unzip it, and place it in the "geometry_data" folder of the PROTEUS simulator. You m…
View article: CFD models for the PROTEUS simulator
CFD models for the PROTEUS simulator Open
This archive file contains the CFS simulation and corresponding model to use with the PROTEUS simulator. You can replace the empty "geometry_data" folder in the simulator by this (unzipped) folder.
View article: Nonlinear interaction of two cross-propagating plane waves
Nonlinear interaction of two cross-propagating plane waves Open
An ideal contrast-enhanced ultrasound image should display microbubble-induced nonlinearities while avoiding wave propagation nonlinearities. One of the most successful ultrasound pulse sequences to disentangle these nonlinear effects reli…
View article: Cryo-EM structure of gas vesicles for buoyancy-controlled motility
Cryo-EM structure of gas vesicles for buoyancy-controlled motility Open
View article: Biomolecular actuators for genetically selective acoustic manipulation of cells
Biomolecular actuators for genetically selective acoustic manipulation of cells Open
The ability to physically manipulate specific cells is critical for the fields of biomedicine, synthetic biology, and living materials. Ultrasound has the ability to manipulate cells with high spatiotemporal precision via acoustic radiatio…
View article: Cryo-EM structure of gas vesicles for buoyancy-controlled motility
Cryo-EM structure of gas vesicles for buoyancy-controlled motility Open
Gas vesicles allow a diverse group of bacteria and archaea to move in the water column by controlling their buoyancy (1). These gas-filled cellular nanocompartments are formed by up to micrometers long protein shells that are permeable onl…
View article: Volumetric ultrasound localization microscopy of the whole brain microvasculature
Volumetric ultrasound localization microscopy of the whole brain microvasculature Open
Technologies to visualize whole organs across scales in vivo are essential for our understanding of biology in health and disease. To date, only post-mortem techniques achieve cellular resolution across entire organs. 2D ultrasound localiz…
View article: Retrieving Pulsatility in Ultrasound Localization Microscopy
Retrieving Pulsatility in Ultrasound Localization Microscopy Open
Ultrasound localization microscopy (ULM) is a vascular imaging method that provides a 10-fold improvement in resolution compared to ultrasound Doppler imaging. Because typical ULM acquisitions accumulate large numbers of synthetic microbub…
View article: Volumetric Ultrasound Localization Microscopy of the Whole Rat Brain Microvasculature
Volumetric Ultrasound Localization Microscopy of the Whole Rat Brain Microvasculature Open
Technologies to visualize whole organs across scales in vivo are essential for our understanding of biology in health and disease. To date, only post-mortem techniques achieve cellular resolution across entire organs. Here, we demonstrate …
View article: Doppler Slicing for Ultrasound Super-Resolution Without Contrast Agents
Doppler Slicing for Ultrasound Super-Resolution Without Contrast Agents Open
Much of the information needed for diagnosis and treatment monitoring of diseases like cancer and cardiovascular disease is found at scales below the resolution limit of classic ultrasound imaging. Recently introduced vascular super-locali…
View article: Volumetric ultrasound localization microscopy of the whole brain microvasculature
Volumetric ultrasound localization microscopy of the whole brain microvasculature Open
Technologies to visualize whole organs across scales in vivo are essential for our understanding of biology in health and disease. To date, only post-mortem techniques such as perfused computed tomography scanning or optical microscopy of …
View article: Single-trial decoding of movement intentions using functional ultrasound neuroimaging
Single-trial decoding of movement intentions using functional ultrasound neuroimaging Open
View article: The Advent of Biomolecular Ultrasound Imaging
The Advent of Biomolecular Ultrasound Imaging Open
Ultrasound imaging is one of the most widely used modalities in clinical practice, revealing human prenatal development but also arterial function in the adult brain. Ultrasound waves travel deep within soft biological tissues and provide …
View article: Biomolecular Ultrasound Imaging of Phagolysosomal Function
Biomolecular Ultrasound Imaging of Phagolysosomal Function Open
Phagocytic clearance and lysosomal processing of pathogens and debris are essential functions of the innate immune system. However, the assessment of these functions in vivo is challenging because most nanoscale contrast agents comp…
View article: Publisher Correction: Acoustic biosensors for ultrasound imaging of enzyme activity
Publisher Correction: Acoustic biosensors for ultrasound imaging of enzyme activity Open
View article: Acoustic biosensors for ultrasound imaging of enzyme activity
Acoustic biosensors for ultrasound imaging of enzyme activity Open
View article: Single Trial Decoding of Movement Intentions Using Functional Ultrasound Neuroimaging
Single Trial Decoding of Movement Intentions Using Functional Ultrasound Neuroimaging Open
Brain-machine interfaces (BMI) are powerful devices for restoring function to people living with paralysis. Leveraging significant advances in neurorecording technology, computational power, and understanding of the underlying neural signa…
View article: Quantitative imaging of coronary flows using 3D ultrafast Doppler coronary angiography
Quantitative imaging of coronary flows using 3D ultrafast Doppler coronary angiography Open
Coronary flow rate remains complex to assess in clinical practice using non-invasive, non-ionizing imaging tools. In this study, we introduce 3D ultrafast Doppler coronary angiography (3D UDCA), an ultrasound-based method to assess coronar…
View article: Acoustic biomolecules enhance hemodynamic functional ultrasound imaging of neural activity
Acoustic biomolecules enhance hemodynamic functional ultrasound imaging of neural activity Open
View article: Acoustic biomolecules enhance hemodynamic functional ultrasound imaging of neural activity
Acoustic biomolecules enhance hemodynamic functional ultrasound imaging of neural activity Open
Hemodynamic functional ultrasound imaging (fUS) of neural activity provides a unique combination of spatial coverage, spatiotemporal resolution and compatibility with freely moving animals. However, deep and transcranial monitoring of brai…