David Hervás
YOU?
Author Swipe
View article: Experimental Airway Allogenic Transplantation Model with Decellularized Cryopreserved Tracheas
Experimental Airway Allogenic Transplantation Model with Decellularized Cryopreserved Tracheas Open
Background/Objectives: Tracheal replacement remains an unmet necessity in airway pathology treatment. We describe a decellularization and cryopreservation tracheal replacement protocol tested in vivo. Methods: A prospective experimental co…
View article: miRNAs as Epigenetic Biomarkers for CTEPH: A case-control study towards personalized medicine
miRNAs as Epigenetic Biomarkers for CTEPH: A case-control study towards personalized medicine Open
Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of acute pulmonary embolism (PE) in which delayed diagnosis significantly affects patient health outcomes. This case-control study aimed to identify a set of mi…
View article: Evaluation of microbial-derived metabolites in patients with acute pulmonary embolism. Findings from the MICTEP study
Evaluation of microbial-derived metabolites in patients with acute pulmonary embolism. Findings from the MICTEP study Open
Patients with acute pulmonary embolism (PE) exhibit significant differences in the serological concentrations of microbial-derived metabolites (MDMs) compared to healthy controls, as well as in relation to etiological risk factors. Introdu…
View article: Validation of a microRNA profile in urine liquid biopsy with diagnostic and stratification value for bladder cancer classification, available through the open app BladdermiRaCan
Validation of a microRNA profile in urine liquid biopsy with diagnostic and stratification value for bladder cancer classification, available through the open app BladdermiRaCan Open
View article: Blood DNA Methylation in Nuclear and Mitochondrial Sequences Links to Malnutrition and Poor Prognosis in ALS: A Longitudinal Study
Blood DNA Methylation in Nuclear and Mitochondrial Sequences Links to Malnutrition and Poor Prognosis in ALS: A Longitudinal Study Open
Background: Malnutrition in amyotrophic lateral sclerosis (ALS) is associated with disease severity, and epigenetic regulation may be involved. The aim of this study was to assess the methylation levels of specific DNA sequences from the n…
View article: Malignant Transformation of Proliferative Verrucous Leukoplakia: A Description of the Clinical Oral Characteristics of These Squamous Cell Carcinomas
Malignant Transformation of Proliferative Verrucous Leukoplakia: A Description of the Clinical Oral Characteristics of These Squamous Cell Carcinomas Open
Background/Objectives: Proliferative verrucous leukoplakia (PVL) is an oral disorder with the greatest degree of malignant transformation. However, it is relatively rare. This study compared the clinical characteristics of patients with or…
View article: The impact of perinatal factors on executive function development in 30 months infants following threatened preterm labour: a cohort study
The impact of perinatal factors on executive function development in 30 months infants following threatened preterm labour: a cohort study Open
View article: Malignant Transformation of Proliferative Verrucous Leukoplakia: A Description of the Clinical Characteristics of These Oral Cancers
Malignant Transformation of Proliferative Verrucous Leukoplakia: A Description of the Clinical Characteristics of These Oral Cancers Open
Background/Objectives: Proliferative verrucous leukoplakia (PVL) is the oral disorder with the greatest degree of malignant transformation. However, it is relatively rare. This study compared the clinical characteristics of patients with o…
View article: Guaranteeism in the Delivery of Justice in Mexico
Guaranteeism in the Delivery of Justice in Mexico Open
View article: Endoscopic thoracic sympathectomy for primary hyperhidrosis: an over a decade-long follow-up on efficacy, impact, and patient satisfaction
Endoscopic thoracic sympathectomy for primary hyperhidrosis: an over a decade-long follow-up on efficacy, impact, and patient satisfaction Open
Endoscopic thoracic sympathectomy is an effective and safe treatment for palmar and axillary PHH, with a relatively low rate of CS which, when present, is typically mild, making it a highly satisfactory treatment option for patients.
View article: Genome‐wide DNA methylation in early‐onset dementias brain tissue and lymphoblastoid cell lines
Genome‐wide DNA methylation in early‐onset dementias brain tissue and lymphoblastoid cell lines Open
Background Epigenetic mechanisms as a potential underlying pathogenic mechanism of neurodegenerative diseases have been the scope of several studies performed so far. However, there is a gap in analyzing different forms of early‐onset deme…
View article: Estimation of the Real Incidence of a Contagious Disease Through a Bayesian Multilevel Model: Study of COVID-19 in Spanish Provinces
Estimation of the Real Incidence of a Contagious Disease Through a Bayesian Multilevel Model: Study of COVID-19 in Spanish Provinces Open
Background: Pandemic outbreaks have emerged as a significant global threat, with the potential to cause waves of infections that challenge public health systems and disrupt societal norms. Understanding the underlying behavior of disease t…
View article: 20214. IMPACTO DEL NIVEL SOCIOECONÓMICO EN LA SUPERVIVENCIA DE PACIENTES CON ELA
20214. IMPACTO DEL NIVEL SOCIOECONÓMICO EN LA SUPERVIVENCIA DE PACIENTES CON ELA Open
View article: 20733. HISTORIA NATURAL DE PACIENTES CON ATROFIA MUSCULAR ESPINAL CON 3 Y 4 COPIAS DEL GEN SMN2. DATOS DEL REGISTRO NACIONAL ESPAÑOL (CUIDAME)
20733. HISTORIA NATURAL DE PACIENTES CON ATROFIA MUSCULAR ESPINAL CON 3 Y 4 COPIAS DEL GEN SMN2. DATOS DEL REGISTRO NACIONAL ESPAÑOL (CUIDAME) Open
View article: The cross-sectional area of the median nerve: An independent prognostic biomarker in amyotrophic lateral sclerosis
The cross-sectional area of the median nerve: An independent prognostic biomarker in amyotrophic lateral sclerosis Open
The CSAmn is an easy to assess biomarker that seems reliable and reproducible. Our data also suggest that it could act as a progression and prognostic biomarker in ALS patients. Longitudinal studies with repeated measures are warranted to …
View article: clickR: Semi-automatic pre-processing of messy data with change tracking for integral dataset cleaning
clickR: Semi-automatic pre-processing of messy data with change tracking for integral dataset cleaning Open
View article: Proliferative verrucous and homogeneous Leukoplakias exhibit differential methylation patterns
Proliferative verrucous and homogeneous Leukoplakias exhibit differential methylation patterns Open
Objective Proliferative verrucous leukoplakia (PVL) is considered a clinically distinct entity from other oral leucoplakias (OLs) due to its clinical presentation and evolution. However, molecular differences between them remain unclear. W…
View article: Genome-Wide DNA Methylation in Early-Onset-Dementia Patients Brain Tissue and Lymphoblastoid Cell Lines
Genome-Wide DNA Methylation in Early-Onset-Dementia Patients Brain Tissue and Lymphoblastoid Cell Lines Open
Epigenetics, a potential underlying pathogenic mechanism of neurodegenerative diseases, has been in the scope of several studies performed so far. However, there is a gap in regard to analyzing different forms of early-onset dementia and t…
View article: Virtual Screening of Small Molecules Targeting BCL2 with Machine Learning, Molecular Docking, and MD Simulation
Virtual Screening of Small Molecules Targeting BCL2 with Machine Learning, Molecular Docking, and MD Simulation Open
This study aimed to identify potential BCL-2 small molecule inhibitors using deep neural networks (DNN) and random forest (RF), algorithms as well as molecular docking and molecular dynamics (MD) simulations to screen a library of small mo…
View article: Understanding the course of attention deficit hyperactivity disorder in children born after a threatened preterm labor: a 6-year cohort study
Understanding the course of attention deficit hyperactivity disorder in children born after a threatened preterm labor: a 6-year cohort study Open
View article: Pain in Children and Adolescents with Spinal Muscular Atrophy: A Longitudinal Study from a Patient Registry
Pain in Children and Adolescents with Spinal Muscular Atrophy: A Longitudinal Study from a Patient Registry Open
Spinal muscular atrophy (SMA) is a devastating genetic neurodegenerative disease caused by the insufficient production of Survival Motor Neuron (SMN) protein. It presents different phenotypes with frequent contractures and dislocations, sc…
View article: EPIC Array Study in Liquid Biopsy Identifies a Non-invasive Epigenetic Signature for Early Diagnosis in Non-small Cell Lung Cancer
EPIC Array Study in Liquid Biopsy Identifies a Non-invasive Epigenetic Signature for Early Diagnosis in Non-small Cell Lung Cancer Open
View article: Is the long-term mortality similar in COVID-19 and community-acquired pneumonia?
Is the long-term mortality similar in COVID-19 and community-acquired pneumonia? Open
Introduction There are no data on the association of type of pneumonia and long-term mortality by the type of pneumonia (COVID-19 or community-acquired pneumonia [CAP]) on long-term mortality after an adjustment for potential confounding v…
View article: Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis
Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis Open
Resveratrol (RSV) holds promise as cerebroprotective treatment in cerebral ischemia. This systematic review aims to assess the effects and mechanisms of RSV in animal models of ischemic stroke. We searched Medline, Embase and Web of Scienc…
View article: PB1022 MicroRNAs Expression before and after Exercise in Patients with Residual Thrombosis after Pulmonary Embolism
PB1022 MicroRNAs Expression before and after Exercise in Patients with Residual Thrombosis after Pulmonary Embolism Open
View article: Implementación de aprendizaje colaborativo, software R y evaluación orientada al aprendizaje de competencias en estudiantes de econometría
Implementación de aprendizaje colaborativo, software R y evaluación orientada al aprendizaje de competencias en estudiantes de econometría Open
En esta innovación docente se ha abordado la problemática de la falta de motivación de los alumnos del grado de dirección y administración de empresas por las asignaturas del área de estadística, así como el aprendizaje demasiado mecánico …
View article: Sex Differences in Opioid Response Linked to OPRM1 and COMT genes DNA Methylation/Genotypes Changes in Patients with Chronic Pain
Sex Differences in Opioid Response Linked to OPRM1 and COMT genes DNA Methylation/Genotypes Changes in Patients with Chronic Pain Open
Analgesic-response variability in chronic noncancer pain (CNCP) has been reported due to several biological and environmental factors. This study was undertaken to explore sex differences linked to OPRM1 and COMT DNA methylation changes an…
View article: Neutrophil Extracellular Traps and Platelet Activation for Identifying Severe Episodes and Clinical Trajectories in COVID-19
Neutrophil Extracellular Traps and Platelet Activation for Identifying Severe Episodes and Clinical Trajectories in COVID-19 Open
The role of NETs and platelet activation in COVID-19 is scarcely known. We aimed to evaluate the role of NETs (citrullinated histone H3 [CitH3], cell-free DNA [cfDNA]) and platelet activation markers (soluble CD40 ligand [CD40L] and P-sele…
View article: Supplementary table 2 from A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer
Supplementary table 2 from A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer Open
Primers for pyrosequencing and priority list.
View article: Supplementary material and Supplementary table 1 from A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer
Supplementary material and Supplementary table 1 from A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer Open
Study design participants, supplementary figure legends and List of cancer-related differentially methylated CpGs