Martin Ogwang
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View article: Integrating Pathogenic Variants, Polygenic Risk Score, and Family History for Prostate Cancer Risk Estimation in Men of African Ancestry
Integrating Pathogenic Variants, Polygenic Risk Score, and Family History for Prostate Cancer Risk Estimation in Men of African Ancestry Open
Integration of PV status, PRS, and family history enables more refined PCa risk estimates. The wide range of PCa risk observed among men of African ancestry in our study supports future prospective studies in the development of risk-strati…
View article: Evidence of latent-lytic replication in EBV-positive Burkitt lymphoma from whole genome and transcriptome sequencing
Evidence of latent-lytic replication in EBV-positive Burkitt lymphoma from whole genome and transcriptome sequencing Open
Epstein–Barr virus (EBV) is a ubiquitous human herpesvirus linked to multiple malignancies, but its role in disease remains uncertain. We analysed 410 EBV genomes, including 64 newly sequenced isolates from plasma of East African children …
View article: Clinical Validation of Liquid Biopsy for Faster Molecular Diagnosis of EBV-Positive Burkitt Lymphoma
Clinical Validation of Liquid Biopsy for Faster Molecular Diagnosis of EBV-Positive Burkitt Lymphoma Open
Burkitt Lymphoma (BL) is common in sub-Saharan Africa, but its diagnosis is often delayed. Here, we comprehensively evaluate blood-based liquid biopsies from 377 children and young adults with clinically suspected lymphoma for diagnostic a…
View article: Supplementary Tables from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features
Supplementary Tables from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features Open
S1. DMRs EBVpos vs CB S2. DMRs EBVneg vs CB S3. Shared DMRs EBV S4. DMRs EBV status S5. Methylation gene corrs EB S6. GO pathways enrichment S7. LPS selected probes S8. Epitype assignment S9. DMRs eptiype S10. DMR gene corrs epitype S11. J…
View article: Supplementary Figures from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features
Supplementary Figures from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features Open
Supplemental Figure 1. Association between genetic alterations and methylation patterns Supplemental Figure 2. Epitypes characteristics and their relation to other lymphomas. Supplemental Figure 3. Comparison of epitype characteristics in …
View article: Data from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features
Data from DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features Open
The genetic subtypes of Burkitt lymphoma have been defined, but the role of epigenetics remains to be comprehensively characterized. We searched genomic DNA from 218 patients across four continents for recurrent DNA methylation patterns an…
View article: DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features
DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features Open
The genetic subtypes of Burkitt lymphoma have been defined, but the role of epigenetics remains to be comprehensively characterized. We searched genomic DNA from 218 patients across four continents for recurrent DNA methylation patterns an…
View article: Rituximab for children with EBV-positive Burkitt lymphoma in East Africa
Rituximab for children with EBV-positive Burkitt lymphoma in East Africa Open
The addition of rituximab to the chemotherapy backbone was shown to significantly improve outcomes of children with aggressive high-grade lymphomas in high-income countries. However, data on its safety and efficacy in children with Epstein…
View article: Global Surgery Dilemmas: When Informed Consent Shifts - A Case Report of Gastric Perforation for Emergency Exploratory Laparotomy on Operating Table
Global Surgery Dilemmas: When Informed Consent Shifts - A Case Report of Gastric Perforation for Emergency Exploratory Laparotomy on Operating Table Open
particularly challenging scenario where a patient's consent for an Ex-LAP procedure shifted dramatically, raising questions about the intricacies of ethical practice in global surgery. CASE PRESENTATION Patient's History"ON", a 43 years ma…
View article: GENOME‐WIDE ASSOCIATION STUDY OF CHILDHOOD BURKITT LYMPHOMA IN EAST AFRICA IDENTIFIES A NOVEL GERMLINE SUSCEPTIBILITY LOCUS ON CHROMOSOME 21
GENOME‐WIDE ASSOCIATION STUDY OF CHILDHOOD BURKITT LYMPHOMA IN EAST AFRICA IDENTIFIES A NOVEL GERMLINE SUSCEPTIBILITY LOCUS ON CHROMOSOME 21 Open
Introduction: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma with hallmark somatic IG::MYC chromosomal translocations. BL is responsible for a significant proportion of childhood cancers in equatorial Africa, where exposure to Epst…
View article: Evidence of Artemisinin-Resistant Malaria in Africa
Evidence of Artemisinin-Resistant Malaria in Africa Open
The independent emergence and local spread of clinically artemisinin-resistant P. falciparum has been identified in Africa. The two kelch13 mutations may be markers for detection of these resistant parasites. (Funded by the J…
View article: Incidental cholecystocolonic fistula in obstructive jaundice
Incidental cholecystocolonic fistula in obstructive jaundice Open
Cholecystocolonic fistula is a rare condition often diagnosed intraoperatively, requiring an adequate set of knowledge and skills to allow safe intraoperative change of prior planned surgery and alleviate significant morbidity.
View article: Access to pediatric surgery delivered by general surgeons and anesthesia providers in Uganda: Results from 2 rural regional hospitals
Access to pediatric surgery delivered by general surgeons and anesthesia providers in Uganda: Results from 2 rural regional hospitals Open
This investigation demonstrates that lifesaving pediatric procedures are safely performed by general surgeons in Uganda. General surgeons who perform pediatric surgery significantly increase surgical access to rural regions of the country …
View article: Community views on short birth interval in Northern Uganda: a participatory grounded theory
Community views on short birth interval in Northern Uganda: a participatory grounded theory Open
Background Short birth interval is associated with adverse perinatal, maternal, and infant outcomes, although evidence on actionable factors underlying short birth interval remains limited. We explored women and community views on short bi…
View article: Policy Implementation Challenges and Barriers to Access Sexual and Reproductive Health Services Faced By People With Disabilities: An Intersectional Analysis of Policy Actors’ Perspectives in Post-Conflict Northern Uganda
Policy Implementation Challenges and Barriers to Access Sexual and Reproductive Health Services Faced By People With Disabilities: An Intersectional Analysis of Policy Actors’ Perspectives in Post-Conflict Northern Uganda Open
Background: Emerging from a 20-year armed conflict, Uganda adopted several laws and policies to protect the rights of people with disabilities, including their sexual and reproductive health (SRH) rights. However, the SRH rights of people …
View article: Communities and service providers address access to perinatal care in postconflict Northern Uganda: socialising evidence for participatory action
Communities and service providers address access to perinatal care in postconflict Northern Uganda: socialising evidence for participatory action Open
Objectives Describe participatory codesign of interventions to improve access to perinatal care services in Northern Uganda. Study design Mixed-methods participatory research to codesign increased access to perinatal care. Fuzzy cognitive …
View article: Exploring the impact of a community participatory intervention on women's capability: a qualitative study in Gulu Northern Uganda
Exploring the impact of a community participatory intervention on women's capability: a qualitative study in Gulu Northern Uganda Open
Background Community participatory interventions mobilizing women of childbearing age are an effective strategy to promote maternal and child health. In 2017, we implemented this strategy in Gulu Northern Uganda. This study explored the pe…
View article: Additional file 2 of Community views on short birth interval in Northern Uganda: a participatory grounded theory
Additional file 2 of Community views on short birth interval in Northern Uganda: a participatory grounded theory Open
Additional file 2. Thematic analysis for child spacing benefits.
View article: Additional file 1 of Community views on short birth interval in Northern Uganda: a participatory grounded theory
Additional file 1 of Community views on short birth interval in Northern Uganda: a participatory grounded theory Open
Additional file 1. Thematic analysis for causes underlying short birth intervals.
View article: Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in Northern Uganda
Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in Northern Uganda Open
In Uganda, artemether-lumefantrine was introduced as an artemisinin-based combination therapy (ACT) for malaria in 2006. We have previously reported a moderate decrease in ex vivo efficacy of lumefantrine in Northern Uganda, where we also …
View article: Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya
Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya Open
Background Endemic Burkitt lymphoma (eBL) is an aggressive B cell non-Hodgkin lymphoma associated with antigenic stimulation from Plasmodium falciparum malaria. Whether eBL risk is related to malaria parasite density is unknown. To address…
View article: Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda
Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda Open
Background Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites. Since the first report in Malawi, numerous epidemiologica…
View article: Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda.
Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda. Open
Background Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites. Since the first report in Malawi, numerous epidemiologica…
View article: Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda.
Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda. Open
Background Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites. Since the first report in Malawi, numerous epidemiologica…
View article: Unifying Children’s Surgery and Anesthesia Stakeholders Across Institutions and Clinical Disciplines: Challenges and Solutions from Uganda
Unifying Children’s Surgery and Anesthesia Stakeholders Across Institutions and Clinical Disciplines: Challenges and Solutions from Uganda Open
Background There is a significant unmet need for children’s surgical care in low‐ and middle‐income countries (LMICs). Multidisciplinary collaboration is required to advance the surgical and anesthesia care of children’s surgical condition…
View article: Cango Lyec (Healing the Elephant): Gender Differences in HIV Infection in Post-conflict Northern Uganda
Cango Lyec (Healing the Elephant): Gender Differences in HIV Infection in Post-conflict Northern Uganda Open
Background: As previously encamped resettle, potential for rapid HIV transmission in post-conflict Northern Uganda is concerning. Women in particular may be experiencing heightened vulnerability resulting from war-related sexual violence. …