Explanipedia

Continuous Flow Techniques in the Total Synthesis of Jaspine B: Part II Open

Michal Gurský, Dorotea Trnovcová, Pavol Lopatka, Martin Markovič, Peter Koóš , et al. · 2025

In this work, we report on the completion of the total synthesis of jaspine B from Garner's aldehyde using a Pd-catalyzed carbonylation strategy under continuous flow conditions. The target compound was synthesized from the key intermediat…

Straightforward, scalable, solution-phase synthesis of peptide bonds in flow Open

Zoe E. Wilson, Enol López, Nils J. Flodén, Charis Watkins, Giulia Bianchini , et al. · 2025

We report the development of simple solution-phase flow conditions for the scalable synthesis of peptides using in-situ activation as mixed anhydrides, contributing to the synthetic toolbox of available solution-phase flow reactions. This …

Antascomicin B stabilizes FKBP51-Akt1 complexes as a molecular glue Open

Sabine C. Schäfer, Andreas M. Voll, Andreas Bracher, Steven V. Ley, Felix Hausch · 2024

Nitro-sulfinate Reductive Coupling to Access (Hetero)aryl Sulfonamides Open

Sandra E. Gatarz, Oliver Griffiths, Henrique A. Esteves, Wenhua Jiao, Peter Morse , et al. · 2024

A method to assemble (hetero)aryl sulfonamides via the reductive coupling of aryl sulfinates and nitroarenes is reported. Various reducing conditions with sodium bisulfite and with or without tin(II) chloride in DMSO were developed using a…

Continuous flow synthesis enabling reaction discovery Open

Antonella Ilenia Alfano, Jorge García‐Lacuna, Oliver Griffiths, Steven V. Ley, Marcus Baumann · 2024

This Perspective article highlights recent studies in which continuous flow approaches exploiting photochemical, electrochemical, and thermal reactions led to the discovery and subsequent exploitation of new reactions and reactivity patter…

Photoredox‐Catalyzed Preparation of Sulfones Using Bis‐Piperidine Sulfur Dioxide – An Underutilized Reagent for SO2 Transfer Open

Oliver Griffiths, Henrique A. Esteves, Darcy C. Emmet, Steven V. Ley · 2023

Sulfonyl groups are widely observed in biologically relevant molecules and consequently, SO 2 capture is an increasingly attractive method to prepare these sulfonyl‐containing compounds given the range of SO 2 ‐surrogates now available as …

Automated multistep synthesis of 2-pyrazolines in continuous flow Open

Ricardo Labes, Julio Cezar Pastre, Richard J. Ingham, Claudio Battilocchio, Henrique Magri Marçon , et al. · 2023

The synthesis of 2-pyrazolines from aldehydes via cycloaddition of unstabilised diazo species and alkenes is reported, including automated library generation and graphical interface for reaction control.

The Evolution of Flow Chemistry: An Opinion on Factors Driving Innovation Open

Samuel L. Bourne, Franz Amann, Steven V. Ley · 2023

This article seeks to provide an overview of the environmental factors within the pharmaceutical industry that have contributed to the emergence of flow chemistry over the past two decades. It highlights some of the challenges facing the i…

Exploring the chemical space of phenyl sulfide oxidation by automated optimization Open

Pia Mueller, Aikaterini Vriza, Adam D. Clayton, Oliver May, Norman Govan , et al. · 2023

Automated platforms allow for rapid, detailed screening of chemical systems.

CCDC 2190648: Experimental Crystal Structure Determination Open

Oliver M. Griffiths, Steven V. Ley · 2022

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Multicomponent Direct Assembly of N-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis Open

Oliver Griffiths, Steven V. Ley · 2022

N-heterospirocycles are interesting structural units found in both natural products and medicinal compounds but have relatively few reliable methods for their synthesis. Here, we enlist the photocatalytic generation of N-cent…

Data for "Fast Continuous Alcohol Amination Employing a Hydrogen Borrowing Protocol" Open

Ricardo Labes, Carlos Mateos, Claudio Battilocchio, Yiding Chen, P. R. Dingwall , et al. · 2021

NMR and HRMS raw data for the communication entitled "Fast Continuous Alcohol Amination Employing a Hydrogen Bor-rowing Protocol" \nNMR spectroscopy: 1H-NMR spectra were recorded on a 400 MHz Avance III HD spectrometer or Bruker Avance DPX…

Frontmatter Open

Ferenç Darvas, György Dormán, Volker Hessel, Steven V. Ley · 2021

Frontmatter Open

Ferenç Darvas, György Dormán, Volker Hessel, Steven V. Ley · 2021

Photoredox-Catalyzed Dehydrogenative Csp3–Csp2 Cross-Coupling of Alkylarenes to Aldehydes in Flow Open

Oliver Griffiths, Henrique A. Esteves, Yiding Chen, Karin Sowa, Oliver May , et al. · 2021

Executing photoredox reactions in flow offers solutions to frequently encountered issues regarding reproducibility, reaction time, and scale-up. Here, we report the transfer of a photoredox-catalyzed benzylic coupling of alkylarenes to ald…

Formation and utility of reactive ketene intermediates under continuous flow conditions Open

Harry R. Smallman, Jamie A. Leitch, Tom McBride, Steven V. Ley, Duncan L. Browne · 2021

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells Open

Sougata Roy, James Sipthorp, Bidesh Mahata, Jhuma Pramanik, Marco L. Hennrich , et al. · 2021

Pregnenolone (P5) promotes prostate cancer cell growth, and de novo synthesis of intratumoural P5 is a potential cause of development of castration resistance. Immune cells can also synthesize P5 de novo. Despite its biologic…

A Comment on Continuous Flow Technologies within the Agrochemical Industry Open

Steven V. Ley, Yiding Chen, Alan Robinson, Benjamin Otter, Edouard Godineau , et al. · 2021

The agrochemical sector operates on a large scale within a highly complex environment. Cost-effective production on an increasing scale in a sustainable fashion imposes massive constraints on the industry. Here we offer a perspective on fl…

Research data supporting "Photoredox generation of sulfone radicals and coupling with electron deficient olefins" Open

Yiding Chen, Nicole McNamara, Oliver May, Thanigaimalai Pillaiya, David C. Blakemore , et al. · 2020

Dataset for the titled publication: Photoredox generation of sulfone radicals and coupling with electron deficient olefins. \nThe title of the files and title of folders represent the corresponding NMR spectura and its compound respectivel…

Research data supporting "Real-time spectroscopic analysis enabling the full and safe consumption of fluoroform during nucleophilic trifluoromethylation in flow." Open

Biagia Musio, Elena Gala, Steven V. Ley · 2020

The productive use of toxic waste materials derived from industrial processes is one of the main goals of the modern chemical research to increase the sustainability of the large scale production. Here we devise a simple and robust strateg…

Research data supporting "Rapid, selective and stable HaloTag-LbADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides" Open

Biagia Musio, Steven V. Ley · 2020

A strategy for biocatalyst immobilization in flow directly from the crude cell extract is described. The efficiency and the stability of the immobilized enzyme were demonstrated during the asymmetric reduction of a range of ketones. The ca…

Research data supporting "Continuous direct anodic flow oxidation of aromatic hydrocarbons to benzyl amides" Open

Biagia Musio, Mikhail Kabeshov, Steven V. Ley · 2020

An efficient continuous method to convert aromatic hydrocarbons directly into the benzyl amides using flow electrochemistry was developed. It was found that the conversion to the amide was higher while in the presence of a Brønsted acid ad…

Integrated Batch and Continuous Flow Process for the Synthesis of Goniothalamin Open

Julio Cezar Pastre, Philip R. D. Murray, Duncan L. Browne, Guilherme Andrade Brancaglion, Renan Galaverna , et al. · 2020

An integrated batch and continuous flow process has been developed for the gram-scale synthesis of goniothalamin. The synthetic route hinges upon a telescoped continuous flow Grignard addition followed by an acylation reaction capable of d…

Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins Open

Yiding Chen, Nicole McNamara, Oliver May, Thanigaimalai Pillaiyar, David C. Blakemore , et al. · 2020

Various sulfone tetrazoles were activated via iridium photoredox catalysis in the presence of DMAP to give dialkyl sulfones. The presumed sulfone radical intermediates were trapped by a range of electron deficient olefins in generally good…

In silico rationalisation of selectivity and reactivity in Pd-catalysed C–H activation reactions Open

Liwei Cao, Mikhail Kabeshov, Steven V. Ley, Alexei A. Lapkin · 2020

A computational approach has been developed to automatically generate and analyse the structures of the intermediates of palladium-catalysed carbon–hydrogen (C–H) activation reactions as well as to predict the final products. Implemented a…

Living with our machines: Towards a more sustainable future Open

Steven V. Ley, Yiding Chen, Daniel E. Fitzpatrick, Oliver May · 2020

A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions Open

Daniel E. Fitzpatrick, Matthew O’Brien, Steven V. Ley · 2020

This Tutored Discourse constitutes a preliminary exposure on how synthesis chemists can engage positively with inexpensive, low-power microcontrollers to aid control, monitoring and optimisation of chemical reactions.

A Practical Method for Continuous Production of sp3‐Rich Compounds from (Hetero)Aryl Halides and Redox‐Active Esters Open

Eiichi Watanabe, Yiding Chen, Oliver May, Steven V. Ley · 2019

A practically useful coupling reaction between aromatic halides and redox‐active esters was realized by nickel catalysis through the use of a packed zinc bed column in continuous flow. Multiple reuse of the column showed a negligible decre…

Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source Open

Pavol Lopatka, Martin Markovič, Peter Koóš, Steven V. Ley, Tibor Gracza · 2019

This work discloses a continuous flow carbonylation reaction using iron pentacarbonyl as source of CO. The described transformation using this surrogate was designed for use in commonly accessible flow equipment. Optimized conditions were …

A New World for Chemical Synthesis? Open

Steven V. Ley, Yiding Chen, Daniel E. Fitzpatrick, Oliver May · 2019

This perspective seeks to provide an overarching vision of the current state of chemical synthesis methodology using machinery as enabling tools. It highlights current capabilities and limitations in this highly digitallyconnected world an…

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