David L.S. Morales
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View article: National Experience With Tracheostomy in Neonates Undergoing Congenital Heart Surgery: A Multicenter Analysis
National Experience With Tracheostomy in Neonates Undergoing Congenital Heart Surgery: A Multicenter Analysis Open
OBJECTIVES: Our aim was to describe trends in tracheostomy utilization in infants requiring congenital heart surgery (CHS) during their index admission with specific focus on clinical and financial outcomes. DESIGN: A retrospective cohort …
View article: Personalized Patient-Specific Patch Augmentation Using Virtual Surgical Planning
Personalized Patient-Specific Patch Augmentation Using Virtual Surgical Planning Open
Patient-specific VSP is gaining momentum in congenital heart surgery. It can refine the surgical approach and may lower complications in long-segment AAH repair.
View article: Characterization of human skeletal stem cells in closed and open tibia fractures: a single center pilot study
Characterization of human skeletal stem cells in closed and open tibia fractures: a single center pilot study Open
Introduction Tibial shaft fractures are the most common long bone fractures and carry a significant risk of nonunion, particularly in open injuries. This increased risk has been attributed to heightened activation of damage-associated mole…
View article: Outcomes of Fontan patients undergoing combined heart-liver transplantation in pediatric hospitals across the United States
Outcomes of Fontan patients undergoing combined heart-liver transplantation in pediatric hospitals across the United States Open
This multi-institutional analysis demonstrates the rapidly increasing numbers of Fontan palliated patients successfully undergoing CHLT in pediatric hospitals. Conditional on surviving to discharge, long-term survival has been excellent, d…
View article: An Analytical Cross‐Sectional Study Among Adolescent Patients Who Attempted Suicide and Their Childhood Mobility
An Analytical Cross‐Sectional Study Among Adolescent Patients Who Attempted Suicide and Their Childhood Mobility Open
Problem Suicide rates among adolescents continue to rise globally. Frequent changes in residency can be traumatic for adolescents, increasing their risk of suicidal behaviors. However, the impact of residential mobility on mental health re…
View article: Pressure‐Wire Guided Hybrid Branch Pulmonary Artery Band Placement for Palliation of Single Ventricle and Critical Congenital Cardiac Lesions
Pressure‐Wire Guided Hybrid Branch Pulmonary Artery Band Placement for Palliation of Single Ventricle and Critical Congenital Cardiac Lesions Open
Background Historically, bilateral pulmonary artery band (PAB) placement was guided by pulmonary blood flow surrogates including systemic blood pressure (BP) and arterial saturation. These metrics alone may result in suboptimal bPAB placem…
View article: What is the Cumulative Impact of Race & Social Determinants of Health on Minorities’ Single Ventricle Journey Beyond the First Year
What is the Cumulative Impact of Race & Social Determinants of Health on Minorities’ Single Ventricle Journey Beyond the First Year Open
Background Race and social determinants of health are known to impact stage-I-palliation (S1P) outcomes. Resources are predominantly focused during their first year of life which may reduce the impact of socioeconomic status (SES) and race…
View article: Autologous umbilical cord blood mononuclear cell therapy for hypoplastic left heart syndrome: a nonrandomized control trial of the efficacy and safety of intramyocardial injections
Autologous umbilical cord blood mononuclear cell therapy for hypoplastic left heart syndrome: a nonrandomized control trial of the efficacy and safety of intramyocardial injections Open
Intramyocardial injections of autologous UCB-MNC products into the right ventricular myocardium during stage II palliation surgery failed to enhance cardiac function in patients with hypoplastic left heart syndrome. REGISTERED ON CLINICALT…
View article: Connective tissue disease-related interstitial lung disease and pulmonary hypertension
Connective tissue disease-related interstitial lung disease and pulmonary hypertension Open
Pulmonary hypertension (PH) is an important cause of morbidity and mortality in connective tissue diseases (CTDs) and may develop either in isolation or in combination with interstitial lung disease (ILD). Based on the World Health Organiz…
View article: Investigational New Drug-enabling studies to use genetically modified mesenchymal stromal cells in patients with critical limb ischemia
Investigational New Drug-enabling studies to use genetically modified mesenchymal stromal cells in patients with critical limb ischemia Open
Mesenchymal stromal cells (MSCs) have been tested in multiple clinical trials to treat peripheral artery disease, especially the more severe form called critical limb ischemia. However, MSCs have often not met the expected efficacy endpoin…
View article: Interventional Strategies for Children with Progressive Pulmonary Hypertension Despite Optimal Therapy: An Official American Thoracic Society Clinical Practice Guideline
Interventional Strategies for Children with Progressive Pulmonary Hypertension Despite Optimal Therapy: An Official American Thoracic Society Clinical Practice Guideline Open
Background: Pulmonary hypertension in children is progressive with wide variability in prognosis. This document provides an evidence-based clinical practice guideline for the management of children with progressive pulmonary hypertension d…
View article: ACTION-ARC Pediatric and Adult Congenital Heart Disease Ventricular Assist Device Adverse Event Definitions-2023
ACTION-ARC Pediatric and Adult Congenital Heart Disease Ventricular Assist Device Adverse Event Definitions-2023 Open
Adverse events (AEs) experienced by children and adults with congenital heart disease (CHD) on ventricular assist devices (VADs) are sometimes unique to these populations. The Advanced Cardiac Therapies Improving Outcomes Network (ACTION) …
View article: Kinetics of Renin Concentrations in Infants Undergoing Congenital Cardiac Surgery
Kinetics of Renin Concentrations in Infants Undergoing Congenital Cardiac Surgery Open
Background Elevated renin has been shown to predict poor response to standard vasoactive therapies and is associated with poor outcomes in adults. Similarly, elevated renin was associated with mortality in children with septic shock. Renin…
View article: Flexible bronchoscopy in pediatric lung transplantation
Flexible bronchoscopy in pediatric lung transplantation Open
Pediatric lung transplantation represents a treatment option for children with advanced lung disease or pulmonary vascular disorders who are deemed an appropriate candidate. Pediatric flexible bronchoscopy is an important and evolving fiel…
View article: Deep Learning for Automated Measurement of Total Cardiac Volume for Heart Transplantation Size Matching
Deep Learning for Automated Measurement of Total Cardiac Volume for Heart Transplantation Size Matching Open
Total Cardiac Volume (TCV)-based size matching using Computed Tomography (CT) is a novel technique to compare donor and recipient heart size in pediatric heart transplant that may increase overall utilization of available grafts. TCV requi…
View article: Outcomes of Concomitant Cardiac Surgical Procedures Performed During Pediatric Lung Transplantation in the United States
Outcomes of Concomitant Cardiac Surgical Procedures Performed During Pediatric Lung Transplantation in the United States Open
Data on concomitant cardiac surgery (CCS) performed during pediatric lung transplantation (LTx) is limited. Therefore, we conducted a multi-institutional analysis to identify the incidence and outcomes of CCS in pediatric (< 18 yrs) LTx re…