David G. Muñoz
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PATH-25. Identifying the molecular signature of infiltrating edge cells in glioblastoma as drivers of tumour invasion and recurrence Open
Glioblastoma is the most common malignant brain tumour in adults. Despite extensive research, there haven’t been remarkable gains in resolving the seeds of glioblastoma recurrence, and the outcomes for many patients suffering from this dev…
A Multimodal Evaluation of Transcranial Photobiomodulation in Mild Cognitive Impairment: Cognitive, Metabolic, and Neuroimaging Outcomes of a Pilot Randomized Control Trial Open
INTRODUCTION: Mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease and related dementias (ADRD), offers a critical window for early intervention. Mitochondrial dysfunction is increasingly recognized as a driver of neur…
32 IDENTIFYING THE MOLECULAR SIGNATURE OF INFILTRATING EDGE CELLS IN GLIOBLASTOMA AS DRIVERS OF TUMOUR INVASION AND RECURRENCE Open
BACKGROUND Glioblastoma (GBM) is the most common malignant brain tumour in adults. Despite extensive research, there haven’t been remarkable gains in resolving the seeds of glioblastoma recurrence, and the outcomes for many patients suffer…
View article: Determining the Role of Sex and APOE4 status on Psychosis in Alzheimer’s Disease
Determining the Role of Sex and APOE4 status on Psychosis in Alzheimer’s Disease Open
Background Psychosis occurs in approximately 41% of patients living with Alzheimer’s disease. Previous findings from our group based on analyses of a neuropathological cohort suggest that among AD patients with Lewy Body pathology, female …
A molecular array for 10-second diagnosis of common spinal tumor types with picosecond infrared laser mass spectrometry Open
Background Improving the surgical outcomes for commonly occurring spinal neoplasms of extradural and intradural extramedullary origins requires precise intraoperative diagnosis provided by highly trained neuropathologists. Methods Through …
Depletion of nuclear cytoophidia in Alzheimer's disease Open
There is considerable evidence for a role for metabolic dysregulation, including disordered purine nucleotide metabolism, in the pathogenesis of Alzheimer’s disease (AD). Purine nucleotide synthesis in the brain is regulated with high fide…
Towards a histological diagnosis of childhood small vessel CNS vasculitis Open
Distinct histological features were identified in sv-cPACNS biopsies, including moderate to severe angiocentric inflammatory infiltrates in the cortex or white matter, consisting of CD3, CD4, CD8, and CD20 cells, alongside reactive endothe…
View article: Presence and Severity of Lewy Body Pathology is Modulated by Sex and ApoE4 Zygosity in a Neuropathologically‐Confirmed Alzheimer’s Disease Cohort
Presence and Severity of Lewy Body Pathology is Modulated by Sex and ApoE4 Zygosity in a Neuropathologically‐Confirmed Alzheimer’s Disease Cohort Open
Background The APOE ε4 allele (ApoE4) is a known genetic risk factor for developing Alzheimer’s disease (AD). Previous work by our group demonstrated that female ApoE4 homozygotes with Lewy body (LB) pathology were significantly more likel…
A pilot study evaluating the feasibility, safety, and efficacy of transcranial photobiomodulation (tPBM) for the treatment of mild cognitive impairment (MCI): preliminary findings Open
Background Mild Cognitive Impairment (MCI) is often a precursor to Alzheimer’s dementia (AD). Recent research underscores the relationship between mitochondrial dysfunction and amyloid‐beta accumulation, raising the prospect of targeting m…
View article: Towards a histological diagnosis of childhood small vessel CNS vasculitis
Towards a histological diagnosis of childhood small vessel CNS vasculitis Open
Background: Primary small vessel CNS vasculitis (sv-cPACNS) is a challenging inflammatory brain disease in children. Brain biopsy is mandatory to confirm the diagnosis. This study aims to develop and validate a histological scoring tool fo…
EPCO-38. IDENTIFYING THE MOLECULAR SIGNATURE OF INFILTRATING EDGE IN GLIOBLASTOMA AS DRIVERS OF TUMOUR INVASION AND RECURRENCE Open
Complete tumour resection in glioblastoma patients is not possible. Residual therapy-resistant edge-derived cells drive tumour recurrence and infiltrative expansion in glioblastoma. Features that are specific to malignant edge-derived cell…
Molecular Testing of Central Nervous System Tumours: Recommendations of the Canadian Association of Neuropathologists Open
The diagnosis of central nervous system tumours has been transformed in recent years from a microscopic morphology-based process to one dominated by the identification of somatic genetic alterations in tumour cells. This switch requires im…
View article: Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology
Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology Open
sponsorship: NIA NIH HHS|P30 AG072946, NIA NIH HHS|K24 AG053435, NIA NIH HHS|P30 AG072980, NIA NIH HHS|P30 AG062422, NIA NIH HHS|P01 AG019724, NINDS NIH HHS|U24 NS072026, NIA NIH HHS|P30 AG019610, NIA NIH HHS|P30 AG072972, NIA NIH HHS|P01 …
New neural-inspired controller generalises modularity over lower limb tasks through internal models Open
Predictive neuromuscular models based on neural controllers are a powerful tool for testing assumptions on the underlying architecture of sensorimotor control and its associated neural activity. However, most current controllers suffer fro…
Transglutaminase 2 function in glioblastoma tumor efferocytosis Open
Glioblastoma is an aggressive and incurable type of brain cancer. Regions of tissue necrosis are a distinctive pathological feature of this cancer. These arise through thrombosis of tumor vasculature, driven by tumor-derived pro-coagulatio…
NVTG-03 IDENTIFYING THE DRIVERS OF EARLY BRAIN METASTASES ESTABLISHMENT IN BREAST CANCER PATIENTS Open
Breast cancer is the most common type of cancer in women. It is also the 2nd most common cause of brain metastases (BrM), with 30-50% of breast cancer patients developing BrM over the course of their disease. Despite aggressive therapy and…
View article: Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing
Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing Open
Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide assoc…
View article: LGG-34. THE LANDSCAPE OF GLIOMAS IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS REVEALS INSIGHTS ON GLIOMAGENESIS: A CANADIAN ADOLESCENTS AND YOUNG ADULTS NEURO-ONCOLOGY NETWORK (CANON) STUDY
LGG-34. THE LANDSCAPE OF GLIOMAS IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS REVEALS INSIGHTS ON GLIOMAGENESIS: A CANADIAN ADOLESCENTS AND YOUNG ADULTS NEURO-ONCOLOGY NETWORK (CANON) STUDY Open
BACKGROUND Gliomas are a heterogenous and common cancer in children, adolescents and young adults (CAYA, ages 0-39 years). Little is known about the biologic and clinical implications of gliomas in AYA limiting our ability to appropriately…
Epstein-Barr Virus–Associated Smooth-Muscle Tumor of the Brain Open
Epstein-Barr virus, a herpesvirus, has been associated with a variety of cancers, including Burkitt, Hodgkin, and non-Hodgkin lymphomas; posttransplant lymphoproliferative disorders; gastric carcinoma; and nasopharyngeal carcinoma, in both…
Lipidomic-Based Approach to 10 s Classification of Major Pediatric Brain Cancer Types with Picosecond Infrared Laser Mass Spectrometry Open
Picosecond infrared laser mass spectrometry (PIRL-MS) is shown, through a retrospective patient tissue study, to differentiate medulloblastoma cancers from pilocytic astrocytoma and two molecular subtypes of ependymoma (PF-EPN-A, ST-EPN-RE…
View article: The outcomes measured and reported in intracranial meningioma clinical trials: A systematic review
The outcomes measured and reported in intracranial meningioma clinical trials: A systematic review Open
Background Meningioma clinical trials have assessed interventions including surgery, radiotherapy, and pharmacotherapy. However, agreement does not exist on what, how, and when outcomes of interest should be measured. To do so would allow …
Differences in methylation profiles between long-term survivors and short-term survivors of IDH-wild-type glioblastoma Open
Background Patients with glioblastoma (GBM) have a median overall survival (OS) of approximately 16 months. However, approximately 5% of patients survive >5 years. This study examines the differences in methylation profiles between long-te…
View article: The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review
The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review Open
Background The clinical management of patients with incidental intracranial meningioma varies markedly and is often based on clinician choice and observational data. Heterogeneous outcome measurement has likely hampered knowledge progress …
View article: Sex‐specific neuropsychiatric burden distinguished by APOE4 status and cortical thickness
Sex‐specific neuropsychiatric burden distinguished by APOE4 status and cortical thickness Open
Background The APOE ε4 (APOE4) allele is a genetic risk factor for Alzheimer’s disease (AD). Prior work by our group found a significant association between the APOE4 allele and presence of psychosis as well as overall increased neuropsych…
TMIC-53. TRANSGLUTAMINASE 2 EXPRESSION IN GLIOBLASTOMA: EVIDENCE FOR A ROLE IN EFFEROCYTOSIS Open
Glioblastoma is the most common type of brain cancer in adults. It is currently incurable and there is a clear need for more effective treatments. The heterogeneity of this cancer and its ability to promote both local and systemic immunosu…
PATH-09. THE IMPACT OF MISMATCH REPAIR DEFICIENCY ON GLIOMAS IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS; A MULTI-CENTRIC, COLLABORATIVE STUDY LED BY THE IRRDC AND GLIOMA TASKFORCE Open
BACKGROUND Primary mismatch repair deficiency (pMMRD) is a pan-cancer mechanism caused by somatic mutations or inherited as part of Lynch Syndrome (LS) or constitutional mismatch repair deficiency (CMMRD). PMMRD results in universal hyperm…