Explanipedia

288 Propranolol Use in Adult Burn Patients: Results from a Multi-center Safety and Efficacy Trial Open

David N. Herndon, Joshua Carson, Shawn P. Fagan, Celeste C. Finnerty, Kevin N Foster , et al. · 2023

Introduction The hypermetabolic response induced by a large burn is associated with increased cardiac work, total body wasting, and impaired physical function, leading to delays in psychosocial recovery and reintegration into society, and …

119 Exercise in the ICU and its Effects on Physical and Mental Health in Pediatric Burn Open

Andrea Rego, Ingrid Parry, Soman Sen, Heidi Spratt, Jong Seok Lee , et al. · 2023

Introduction Suffering a severe burn is an event that can have lifelong physical and mental ramifications. Exercise after discharge from the hospital, has been shown to improve quality of life with better physical and mental status in chil…

Effects of Aerobic Exercise in the Intensive Care Unit on Patient-Reported Physical Function and Mental Health Outcomes in Severely Burned Children—A Multicenter Prospective Randomized Trial Open

Alen Palackic, Andrea Rego, Ingrid Parry, Soman Sen, Ludwik K. Branski , et al. · 2023

Severe burns are life-altering and can have lasting effects on patients’ physical and mental health. Alterations in physical function, changes in appearance, and psychological disturbances resulting from severe burns are especially concern…

Comparison of Six-Minute Walk Test and Modified Bruce Treadmill Test in Paediatric Patients With Severe Burns: A Cross-Over Study Open

Alen Palackic, Stephanie Abazie, Ingrid Parry, Soman Sen, Ronald P. Mlcak , et al. · 2022

Objective: To compare the six-minute walk test and the Modified Bruce treadmill test in paediatric patients with severe burns.Subjects: A total of 67 children, aged 7–17 years, with severe burns.Methods: Participants were assigned to perfo…

The effects of short bouts of ergometric exercise for severely burned children in intensive care: A randomized controlled trial Open

Tony Chao, Ingrid Parry, Alen Palackic, Soman Sen, Heidi Spratt , et al. · 2022

Objective To determine the effects of short bouts of ergometric exercises on the number of days in the burn intensive care unit (ICU), body mass, and functional ambulation. Design Multi-center, randomized controlled trial. Setting Burn int…

Thermal injury induces early blood vessel occlusion in a porcine model of brass comb burn Open

Jing Wang, Cheng Z. Wang, John R. Salsbury, Jianzi Zhang, Perenlei Enkhbaatar , et al. · 2021

Metal chelation attenuates oxidative stress, inflammation, and vertical burn progression in a porcine brass comb burn model Open

Amina El Ayadi, John R. Salsbury, Perenlei Enkhbaatar, David N. Herndon, Naseem H. Ansari · 2021

Comparison of Arterial-Venous Balance and Tracer Incorporation Methods for Measuring Muscle Fractional Synthesis and Fractional Breakdown Rates Open

Joshua Hudson, Matthew Cotter, David N. Herndon, Robert R. Wolfe, Elisabet Børsheim · 2021

Loss of muscle mass in response to injury or immobilization impairs functional capacity and metabolic health, thus hindering rehabilitation. Stable isotope techniques are powerful in determining skeletal muscle protein fluxes. Traditional …

Contracture Severity at Hospital Discharge in Children: A Burn Model System Database Study Open

Miranda Yelvington, Matthew Godleski, Austin F. Lee, Jeremy Goverman, Ingrid Parry , et al. · 2020

Contractures can complicate burn recovery. There are limited studies examining the prevalence of contractures following burns in pediatrics. This study investigates contracture outcomes by location, injury, severity, length of stay, and de…

Metal chelation reduces skin epithelial inflammation and rescues epithelial cells from toxicity due to thermal injury in a rat model Open

Amina El Ayadi, Cheng Z. Wang, Min Zhang, Michael D. Wetzel, Anesh Prasai , et al. · 2020

Background One of the most pervasive complications of burn injury is wound progression, characterized by continuous tissue destruction in untreated wounds, which leads to wound infection, inflammation, oxidative stress and excessive scar f…

Adipose-derived stem cells improve grafted burn wound healing by promoting wound bed blood flow Open

Osamu Fujiwara, Anesh Prasai, Dannelys Pérez‐Bello, Amina El Ayadi, Irene Y. Petrov , et al. · 2020

Background Researchers have explored the use of adipose-derived stem cells (ASCs) as a cell-based therapy to cover wounds in burn patients; however, underlying mechanistic aspects are not completely understood. We hypothesized that ASCs wo…

An Examination of Follow-up Services Received by Vulnerable Burn Populations: A Burn Model System National Database Study Open

Lynne Benavides, Vivian L. Shie, Brennan Yee, Miranda Yelvington, L C Simko , et al. · 2019

While disparities in healthcare outcomes and services for vulnerable populations have been documented, the extent to which vulnerable burn populations demonstrate disparities in long-term care is relatively underexplored. This study’s goal…

Peroxynitrite decomposition catalyst reduces vasopressin requirement in ovine MRSA sepsis Open

Osamu Fujiwara, Satoshi Fukuda, Ernesto Lopez, Yaping Zeng, Yosuke Niimi , et al. · 2019

Background Sepsis is one of the most frequent causes of death in the intensive care unit. Host vascular hypo-responsiveness to vasopressors during septic shock is one of the challenging problems. This study tested the hypothesis that adjun…

Early reduced bone formation following burn injury in rats is not inversely related to marrow adiposity Open

Amina El Ayadi, Ron C. Helderman, Celeste C. Finnerty, David N. Herndon, Clifford J. Rosen , et al. · 2019

Surgical anatomy of the ovine sural nerve for facial nerve regeneration and reconstruction research Open

Yosuke Niimi, Satoshi Fukuda, Ryan S. Gilbert, Tuvshintugs Baljinnyam, Yu Niimi , et al. · 2019

The Influence of Obesity on Treatment and Outcome of Severely Burned Patients Open

Christian Tapking, Khosrow Siamak Houschyar, Victoria G. Rontoyanni, Gabriel Hundeshagen, Karl‐Friedrich Kowalewski , et al. · 2019

Obesity and the related medical, social, and economic impacts are relevant multifactorial and chronic conditions that also have a meaningful impact on outcomes following a severe injury, including burns. In addition to burn-specific diffic…

Postacute Care Setting Is Associated With Employment After Burn Injury Open

Leda F. Espinoza, L C Simko, Richard Goldstein, Kara McMullen, Chloe Slocum , et al. · 2019

Monophosphoryl Lipid a Attenuates Multiorgan Dysfunction During Post-Burn Pseudomonas Aeruginosa Pneumonia in Sheep Open

Satoshi Fukuda, Koji Ihara, Julia K. Bohannon, Antonio Hernandez, Naeem K. Patil , et al. · 2019

Background: Monophosphoryl lipid A (MPLA) is a TLR4 agonist that has potent immunomodulatory properties and modulates innate immune function to improve host resistance to infection with common nosocomial pathogens in mice. The goal of this…

A Comparison of Contracture Severity at Acute Discharge in Patients With and Without Heterotopic Ossification: A Burn Model System National Database Study Open

Miranda Yelvington, Matthew Godleski, Austin F. Lee, Jeremy Goverman, David N. Herndon , et al. · 2019

This study assesses the association between heterotopic ossification and upper extremity contracture by comparing goniometric measured active range of motion outcomes of patients with and without heterotopic ossification. Data were obtaine…

The Presence of Scarring and Associated Morbidity in the Burn Model System National Database Open

Jeremy Goverman, Waverley He, Geoffrey Martello, Ann Whalen, Edward A. Bittner , et al. · 2019

Introduction Postburn scarring is common, but the risk factors, natural history, and consequences of such scars are still poorly understood. This study aims to describe the frequency of scar-related morbidity for up to 2 years after injury…

Selected Performance Indicators of University-Model Schools Open

David N. Herndon · 2019

University-Model® schools seek to blend attributes of homeschooling with traditional schooling by transferring a significant portion of classroom time to a satellite classroom, typically the student’s home. Proponents suggest the model len…

Clearance of Indocyanine Green in Severe Pediatric Burns Open

Eva C. Diaz, David N. Herndon, Mario A. Cleves, Ronald P. Mlcak, Asle Aarsland , et al. · 2018

BACKGROUND Clearance of indocyanine green dye (ICGc) reflects sinusoidal perfusion and hepatocyte cell membrane function. Thus, ICGc is a reflection of the functional reserve of intact hepatocytes. The purpose of this study was to identify…

Calpain‐mediated cleavage of p53 in human cytomegalovirus‐infected lung fibroblasts Open

Zhenping Chen, Peter Boor, Celeste C. Finnerty, David N. Herndon, Thomas Albrecht · 2018

Endogenous fragments of p53 protein were identified in human cytomegalovirus (HCMV)‐infected human lung fibroblasts, particularly a 44‐kDa N‐terminal fragment [hereafter referred to as p53(ΔCp44)], generated via calpain cleavage. The fragm…

Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock Open

Satoshi Fukuda, Koji Ihara, Clark R. Andersen, Anita C. Randolph, Christina Nelson , et al. · 2018

Vascular hypo-responsiveness to vasopressors during septic shock is a challenging problem. This study is to test the hypothesis that reactive nitrogen species (RNS), such as peroxynitrite, are major contributing factors to vascular hypo-re…

Negative Pressure Wound Therapy with Instillation and Dwell for the Management of a Complex Burn: A Case Report and Review of the Literature Open

Pablo L. Padilla, Elliott Freudenburg, Katarzyna Kania, Rece W Laney, Ludwik K. Branski , et al. · 2018

Trends 10 years after burn injury: A Burn Model System National Database study Open

Theresa L. Chin, Gretchen J. Carrougher, Dagmar Amtmann, Kara McMullen, David N. Herndon , et al. · 2018

Sepsis Increases Muscle Proteolysis in Severely Burned Adults, but Does not Impact Whole-Body Lipid or Carbohydrate Kinetics Open

Andrew J. Murton, Fredrick J. Bohanon, John O. Ogunbileje, Karel Čapek, Ellen A. Tran , et al. · 2018

Sepsis is a common and often fatal consequence of severe burn injury, but its exact effects on whole body and muscle metabolism in the burn patient is unclear. To address this, 13 septic and 11 nonseptic patients (age: 36.9 ± 13.0 years) w…

Relationship between lean body mass and isokinetic peak torque of knee extensors and flexors in severely burned children Open

Christian Tapking, Andrew M. Armenta, Daniel Popp, David N. Herndon, Ludwik K. Branski , et al. · 2018

Cardiovascular Effect of Varying Interval Training Frequency in Rehabilitation of Severely Burned Children Open

Christian Tapking, Daniel Popp, David N. Herndon, Andrew M. Armenta, Ludwik K. Branski , et al. · 2018

Structured exercise programs initiated after acute hospitalization can improve muscle strength and mass, cardiorespiratory capacity, and quality of life in severely burned children. In this retrospective study, we compared the cardiovascul…

Correlation between invasive and noninvasive blood pressure measurements in severely burned children Open

Janos Cambiaso‐Daniel, Victoria G. Rontoyanni, Guillermo Foncerrada, Anthony V. Nguyen, Karel Čapek , et al. · 2018

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