David J. Nikolic‐Paterson
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View article: Deficiency of mineralocorticoid receptor signalling in myeloid cells protects cardiac and kidney function in hypertensive diabetic mice
Deficiency of mineralocorticoid receptor signalling in myeloid cells protects cardiac and kidney function in hypertensive diabetic mice Open
Mineralocorticoid receptor antagonists (MRAs) reduce hypertension, inflammation and tissue injury in human and experimental diabetes. Inflammation and injury in diabetic hearts and kidneys is also dependent on infiltrating macrophages. The…
View article: Spleen tyrosine kinase signaling in myeloid cells promotes macrophage infiltration, glomerulosclerosis, and interstitial fibrosis in diabetic kidney disease
Spleen tyrosine kinase signaling in myeloid cells promotes macrophage infiltration, glomerulosclerosis, and interstitial fibrosis in diabetic kidney disease Open
Spleen tyrosine kinase (SYK) was shown to be mainly expressed by infiltrating kidney macrophages in human and experimental diabetic kidney disease (DKD), suggesting a potential role for SYK in the progression of this disease. Furthermore, …
View article: Corticosteroids augment cyclosporine nephrotoxicity in pediatric nephrotic syndrome: potential role of alternatively activated macrophages.
Corticosteroids augment cyclosporine nephrotoxicity in pediatric nephrotic syndrome: potential role of alternatively activated macrophages. Open
Background: Cyclosporine A (CsA) is an effective steroid-sparing agent for steroid-dependent nephrotic syndrome (SDNS); however, long-term administration of CsA can induce chronic kidney injury (CsA nephropathy). We previously reported tha…
View article: Tumor Innervation: From Bystander to Emerging Therapeutic Target for Cancer
Tumor Innervation: From Bystander to Emerging Therapeutic Target for Cancer Open
Innervation is ubiquitous in diseased tissues, including cancer. Increasing evidence suggests that innervation not only plays a direct role in cancer pain, but is also closely related to disease progression, including cancer growth, metast…
View article: Comparative Analysis of Human Kidney Organoid and Tubuloid Models
Comparative Analysis of Human Kidney Organoid and Tubuloid Models Open
Key Points Gene expression profiling of tubuloids derived from human fetal kidneys, adult nephrectomies, and kidney organoids reveals common and unique signatures. Induced pluripotent stem cell–derived kidney organoids express higher level…
View article: Immunosuppressant drug tacrolimus inhibits HUVEC angiogenesis and production of placental growth factor
Immunosuppressant drug tacrolimus inhibits HUVEC angiogenesis and production of placental growth factor Open
An acute tacrolimus exposure reduced PlGF secretion and impaired angiogenesis in primary endothelial cells, without affecting. These findings provide a potential mechanistic basis for tacrolimus to contribute to the endothelial dysfunction…
View article: Comparative analysis of iPSC-derived human kidney organoid and tubuloid models
Comparative analysis of iPSC-derived human kidney organoid and tubuloid models Open
Background Epithelial kidney organoids (tubuloids) made from kidney biopsies, urine, or iPSC-derived kidney organoids offer new opportunities in experimental and clinical nephrology. Yet, we have limited knowledge of how tubuloid models di…
View article: The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism
The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism Open
Renal interstitial fibrosis is an important mechanism in the progression of chronic kidney disease (CKD) to end-stage kidney disease. However, we lack specific treatments to slow or halt renal fibrosis. Ribosome profiling identified upregu…
View article: 7747 Poor Sleep Health And Shift Work Are Modifiable Risk Factors For Chronic Kidney Disease In UK Biobank Participants
7747 Poor Sleep Health And Shift Work Are Modifiable Risk Factors For Chronic Kidney Disease In UK Biobank Participants Open
Disclosure: M. Kanki: None. R. Xiang: None. N. Artika: None. D. Nikolic-Paterson: None. G.H. Tesch: None. F. Takeuchi: None. M.J. Young: None. Evaluating the impact of lifestyle factors and work practices on renal function has the potentia…
View article: PAR2 activation on human tubular epithelial cells engages converging signaling pathways to induce an inflammatory and fibrotic milieu
PAR2 activation on human tubular epithelial cells engages converging signaling pathways to induce an inflammatory and fibrotic milieu Open
Key features of chronic kidney disease (CKD) include tubulointerstitial inflammation and fibrosis. Protease activated receptor-2 (PAR2), a G-protein coupled receptor (GPCR) expressed by the kidney proximal tubular cells, induces potent pro…
View article: The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism
The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism Open
Renal interstitial fibrosis is an important mechanism in the progression of chronic kidney disease (CKD) to end-stage kidney disease. However, we lack specific treatments to slow or halt renal fibrosis. Ribosome profiling identified upregu…
View article: Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4
Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4 Open
Ferroptosis is a form of programmed cell death involved in various types of acute kidney injury (AKI). It is characterized by inactivation of the selenoprotein, glutathione peroxidase 4 (GPX4), and upregulation of acyl-CoA synthetase long-…
View article: Podocyte number and glomerulosclerosis indices are associated with the response to therapy for primary focal segmental glomerulosclerosis
Podocyte number and glomerulosclerosis indices are associated with the response to therapy for primary focal segmental glomerulosclerosis Open
Corticosteroid therapy, often in combination with inhibition of the renin-angiotensin system, is first-line therapy for primary focal and segmental glomerulosclerosis (FSGS) with nephrotic-range proteinuria. However, the response to treatm…
View article: Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury
Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury Open
Senescence of kidney tubules leads to tubulointerstitial fibrosis (TIF). Proximal tubular epithelial cells undergo stress-induced senescence during diabetes and episodes of acute kidney injury (AKI), and combining these injuries promotes t…
View article: A gradient model of renal ischemia reperfusion injury to investigate renal interstitial fibrosis
A gradient model of renal ischemia reperfusion injury to investigate renal interstitial fibrosis Open
Background: The progression from acute kidney injury to chronic kidney disease poses a significant health challenge. Nonetheless, a constraint in existing animal models of renal ischemia/reperfusion (I/R) injury is the necessity for a seve…
View article: Single-Cell RNA-Sequencing Identifies Bone Marrow-Derived Progenitor Cells as a Main Source of Extracellular Matrix-Producing Cells Across Multiple Organ-Based Fibrotic Diseases
Single-Cell RNA-Sequencing Identifies Bone Marrow-Derived Progenitor Cells as a Main Source of Extracellular Matrix-Producing Cells Across Multiple Organ-Based Fibrotic Diseases Open
Fibrosis is characterized by the aberrant deposition of extracellular matrix (ECM) due to dysregulated tissue repair responses, imposing a significant global burden on fibrosis-related diseases. Although alpha-smooth muscle actin (α-SMA/AC…
View article: Hypoxic injury triggers maladaptive repair in human kidney organoids
Hypoxic injury triggers maladaptive repair in human kidney organoids Open
Acute kidney injury (AKI) is a common clinical disorder linked to high rates of illness and death. Ischemia is a leading cause of AKI, which can result in chronic kidney disease (CKD) through a maladaptive repair process characterised by f…
View article: A Model of Ischaemia-Induced Renal Interstitial Fibrosis in Mice with Established Diabetes
A Model of Ischaemia-Induced Renal Interstitial Fibrosis in Mice with Established Diabetes Open
Background: Diabetes is a well-established clinical risk factor for the development of acute kidney injury (AKI) following an episode of renal ischaemia. However, we lack a robust animal model to investigate the pathological mechanisms und…
View article: Corrigendum: c-Jun amino terminal kinase signaling promotes aristolochic acid-induced acute kidney injury
Corrigendum: c-Jun amino terminal kinase signaling promotes aristolochic acid-induced acute kidney injury Open
[This corrects the article DOI: 10.3389/fphys.2021.599114.].
View article: The ability of remaining glomerular podocytes to adapt to the loss of their neighbours decreases with age
The ability of remaining glomerular podocytes to adapt to the loss of their neighbours decreases with age Open
Progressive podocyte loss is a feature of healthy ageing. While previous studies have reported age-related changes in podocyte number, density and size and associations with proteinuria and glomerulosclerosis, few studies have examined how…
View article: Editorial: Immune Landscape of Kidney Pathology
Editorial: Immune Landscape of Kidney Pathology Open
EDITORIAL article Front. Physiol., 25 January 2022Sec. Renal Physiology and Pathophysiology Volume 12 - 2021 | https://doi.org/10.3389/fphys.2021.827537
View article: Role of the adaptive immune system in diabetic kidney disease
Role of the adaptive immune system in diabetic kidney disease Open
Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end‐stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response prom…