David P Buennagel
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View article: Heart rate fragmentation during a Stroop task reveals cognitively healthy individuals with pathological CSF amyloid/tau
Heart rate fragmentation during a Stroop task reveals cognitively healthy individuals with pathological CSF amyloid/tau Open
Background Stroop task is used to evaluate inhibition, a core executive function. Alpha Event‐Related Desynchronization (ERD) from analysis of electroencephalogram (EEG) during Stroop task reflects brain interference processing. We previou…
View article: Amyloid ratios in plasma and CSF are biomarkers of pre‐symptomatic Alzheimer’s disease
Amyloid ratios in plasma and CSF are biomarkers of pre‐symptomatic Alzheimer’s disease Open
Background The CSF amyloid to tau ratio can isolate c ognitively h ealthy participants into n ormal A β 42 / t au (CH‐NAT) or a p athological A β 42 / t au (CH‐PAT) with a low or high risk of cognitive decline, respectively. We aim to dete…
View article: Correlation between heartrate and alpha Event‐Related Desynchronization during a Stroop task helps reveal cognitively healthy individuals with pathological CSF amyloid/tau
Correlation between heartrate and alpha Event‐Related Desynchronization during a Stroop task helps reveal cognitively healthy individuals with pathological CSF amyloid/tau Open
Background Alzheimer’s Disease (AD) impacts brain regions associated with memory and executive function in early stages. The Stroop task is used to evaluate inhibition, a common factor for executive functioning. Alpha Event‐Related Desynch…
View article: Larger hippocampal and temporal lobe volume may associate with early rapid forgetting in cognitively healthy individuals with a predisposition to Alzheimer’s disease
Larger hippocampal and temporal lobe volume may associate with early rapid forgetting in cognitively healthy individuals with a predisposition to Alzheimer’s disease Open
Background Growing need exists to link volumetric brain analysis to functional cognitive performance in early prediction of Alzheimer’s disease. Method In cognitively healthy older adults ( N = 40; M age = 71.7±7.7 years), we established a…
View article: Association of urine dicarboxylic acid levels with intracranial volume–normalized brain regions and with white matter hypo‐intensities
Association of urine dicarboxylic acid levels with intracranial volume–normalized brain regions and with white matter hypo‐intensities Open
Background Non‐invasive molecules related to AD imaging biomarkers can reveal disease mechanisms and may help in the mass screening of an aging population. Our study aims to determine if urine dicarboxylic acids (DCA) that changed in AD ar…
View article: Exploring Brain Functional Connectivity in Cognitively Healthy Individuals with Pathological CSF Amyloid/Tau
Exploring Brain Functional Connectivity in Cognitively Healthy Individuals with Pathological CSF Amyloid/Tau Open
Background Disrupted brain connectivity precedes cognitive impairment in Alzheimer’s disease (AD), affects self‐regulation and executive functions, and can be revealed by quantitative electroencephalography (qEEG). Neuroimaging research on…
View article: Changes in urinary odd‐chain and even‐chain saturated fatty acids in Alzheimer’s Disease
Changes in urinary odd‐chain and even‐chain saturated fatty acids in Alzheimer’s Disease Open
Background The health benefits of odd‐chain saturated fatty acids (ocSAFA) have recently been recognized. We previously showed decreased unesterified ocSAFA in cerebrospinal fluid (CSF) of AD compared to MCI and cognitively healthy (CH). H…
View article: Resting heart rate (variability) and cognition relationships reveal cognitively healthy individuals with pathological amyloid/tau ratio
Resting heart rate (variability) and cognition relationships reveal cognitively healthy individuals with pathological amyloid/tau ratio Open
Introduction Resting heart rate (HR) and heart rate variability (HRV) have been linked with cognition in the general population and in older individuals. The knowledge of this aspect of heart-brain relationship is relatively absent in olde…
View article: Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial
Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial Open
HNY was supported by R01AG055770, R01AG054434, R01AG067063 from the National Institute of Aging and NIRG-15-361854 from the Alzheimer's Association, and MGH by the L. K. Whittier Foundation. This work was also supported by P50AG05142 (HCC)…
View article: APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline Open
View article: P1‐165: FOUR‐YEAR LONGITUDINAL STUDY OF COGNITIVELY HEALTHY INDIVIDUALS: CSF AMYLOID/TAU LEVELS AND NANOPARTICLE MEMBRANES IDENTIFY HIGH RISK FOR ALZHEIMER'S DISEASE
P1‐165: FOUR‐YEAR LONGITUDINAL STUDY OF COGNITIVELY HEALTHY INDIVIDUALS: CSF AMYLOID/TAU LEVELS AND NANOPARTICLE MEMBRANES IDENTIFY HIGH RISK FOR ALZHEIMER'S DISEASE Open
AD pathology with falling Aß42 levels in CSF and/or increased brain amyloid deposition on PET is recognized many years before cognitive decline. Previously (Cerebrospinal Fluid Res. 2009), we reported abundant brain-derived nanoparticles i…