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View article: Some Items of Interest to Process R&D Chemists and Engineers
Some Items of Interest to Process R&D Chemists and Engineers Open
ADVERTISEMENT RETURN TO ISSUEPREVHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersJames A. SchwindemanJames A. SchwindemanLaxai, Daufuskie Island, South Carolina 29915, Un…
View article: Sperm Toolbox—A selection of small molecules to study human spermatozoa
Sperm Toolbox—A selection of small molecules to study human spermatozoa Open
Male contraceptive options and infertility treatments are limited, and almost all innovation has been limited to updates to medically assisted reproduction protocols and methods. To accelerate the development of drugs that can either impro…
View article: Sperm Cell Painting: A Mechanism Driven Approach for Drug Discovery in Human Spermatozoa
Sperm Cell Painting: A Mechanism Driven Approach for Drug Discovery in Human Spermatozoa Open
We have adapted the cell painting assay developed by Carpenter and colleagues on cultured U2OS cells to human spermatozoa. In Sperm Cell Painting (SCP) we assemble an image-based quantitative fingerprint of the functional state of sperm. W…
View article: Linearisation of a second-order nonlinear ordinary differential equation
Linearisation of a second-order nonlinear ordinary differential equation Open
We analyse nonlinear second-order differential equations in terms of algebraic properties by reducing a nonlinear partial differential equation to a nonlinear second-order ordinary differential equation via the point symmetry f(v)∂v. The e…
View article: Pyrrolylquinoline-BF2 and BPh2 BODIPY-Type Analogues: Synthesis, Structural Analysis and Photophysical Properties
Pyrrolylquinoline-BF2 and BPh2 BODIPY-Type Analogues: Synthesis, Structural Analysis and Photophysical Properties Open
Two new pyrrolylquinoline-substituted heteroaromatic-containing compounds bearing a central boron bridge have been prepared by a short, high-yielding sequence consisting of Suzuki-coupling of 8-bromoquinoline and N-Boc 2-pyrroleboronic aci…
View article: Substituted Naphthols: Preparations, Applications, and Reactions
Substituted Naphthols: Preparations, Applications, and Reactions Open
Substituted naphthols (SNs) are an important class of chemical compounds present in many natural and synthetic products with biological and pharmaceutical activities. Moreover, the naphthol skeleton has been employed as a starting material…
View article: Catalytic Friedel–Crafts Alkylation of Electron Rich Aromatic Derivatives with α-Aryl Diazoacetates Mediated by Brønsted Acids
Catalytic Friedel–Crafts Alkylation of Electron Rich Aromatic Derivatives with α-Aryl Diazoacetates Mediated by Brønsted Acids Open
The catalytic protonation of aryl diazoacetates by strong Brønsted acids, followed by a Friedel-Crafts alkylation reaction with electron rich aromatic compounds, is reported. The reaction provided in a direct fashion 24 geminal diarylaceta…
View article: CCDC 1839656: Experimental Crystal Structure Determination
CCDC 1839656: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1839655: Experimental Crystal Structure Determination
CCDC 1839655: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1839654: Experimental Crystal Structure Determination
CCDC 1839654: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Silver-Catalyzed 1,3-Acyloxy Migration/Diels–Alder Reaction of 1,9-Dien-4-yne Esters to Partially Hydrogenated Isoquinolines
Silver-Catalyzed 1,3-Acyloxy Migration/Diels–Alder Reaction of 1,9-Dien-4-yne Esters to Partially Hydrogenated Isoquinolines Open
A synthetic method to prepare partially hydrogenated isoquinolines efficiently from silver-mediated [3,3]-sigmatropic rearrangement/Diels-Alder reaction of 1,9-dien-4-yne esters is described. The reactions were shown to be robust with a wi…
View article: CCDC 1508950: Experimental Crystal Structure Determination
CCDC 1508950: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Gold- and Brønsted Acid-Catalyzed Cycloisomerization of 1,8-Diynyl Vinyl Acetates to Bicyclo[2.2.1]hept-2-en-7-ones
Gold- and Brønsted Acid-Catalyzed Cycloisomerization of 1,8-Diynyl Vinyl Acetates to Bicyclo[2.2.1]hept-2-en-7-ones Open
A synthetic method for the efficient assembly of bicyclo[2.2.1]hept-2-en-7-ones that relies on gold(I)-catalyzed Rautenstrauch rearrangement followed by Brønsted acid-mediated formal [3 + 2]-cycloaddition/deacetylation of 1,8-diynyl vinyl …
View article: “Janus” Calixarenes: Double-Sided Molecular Linkers for Facile, Multianchor Point, Multifunctional, Surface Modification
“Janus” Calixarenes: Double-Sided Molecular Linkers for Facile, Multianchor Point, Multifunctional, Surface Modification Open
We herein report the synthesis of novel "Janus" calix[4]arenes bearing four "molecular tethering" functional groups on either the upper or lower rims of the calixarene. These enable facile multipoint covalent attachment to electrode surfac…
View article: Gold‐Catalyzed Cycloisomerizations of 1,<i>n</i>‐Diyne Carbonates and Esters
Gold‐Catalyzed Cycloisomerizations of 1,<i>n</i>‐Diyne Carbonates and Esters Open
Driven by the ever‐growing need for efficient methods to prepare synthetically valuable complex molecules, homogeneous gold catalysis has emerged as an invaluable addition in the organic chemist's toolbox to achieve such goals. Within this…
View article: CCDC 1477182: Experimental Crystal Structure Determination
CCDC 1477182: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1478746: Experimental Crystal Structure Determination
CCDC 1478746: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1418536: Experimental Crystal Structure Determination
CCDC 1418536: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis, Photochemical, and Redox Properties of Gold(I) and Gold(III) Pincer Complexes Incorporating a 2,2′:6′,2″-Terpyridine Ligand Framework
Synthesis, Photochemical, and Redox Properties of Gold(I) and Gold(III) Pincer Complexes Incorporating a 2,2′:6′,2″-Terpyridine Ligand Framework Open
Reaction of [Au(C6F5)(tht)] (tht = tetrahydrothiophene) with 2,2':6',2"-terpyridine (terpy) leads to complex [Au(C6F5)(η(1)-terpy)] (1). The chemical oxidation of complex (1) with 2 equiv of [N(C6H4Br-4)3](PF6) or using electrosynthetic te…
View article: New Non-Toxic Semi-Synthetic Derivatives from Natural Diterpenes Displaying Anti-Tuberculosis Activity
New Non-Toxic Semi-Synthetic Derivatives from Natural Diterpenes Displaying Anti-Tuberculosis Activity Open
We report herein the synthesis of six diterpene derivatives, three of which are new, generated through known organic chemistry reactions that allowed structural modification of the existing natural products kaurenoic acid (1) and copalic a…
View article: CCDC 1422895: Experimental Crystal Structure Determination
CCDC 1422895: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1408217: Experimental Crystal Structure Determination
CCDC 1408217: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …