David Paulding
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View article: <i>Ttc21b</i> is required for proper forebrain neural progenitor proliferation
<i>Ttc21b</i> is required for proper forebrain neural progenitor proliferation Open
Primary cilia play a pivotal role in cellular signaling and development. Human primary microcephaly is strongly associated with pathogenic variants in primary cilia genes. Here, we examine the role of Ttc21b, a component of the intraflagel…
View article: Perdurant TTC21B protein in the early mouse embryo is required for proper forebrain neural progenitor proliferation
Perdurant TTC21B protein in the early mouse embryo is required for proper forebrain neural progenitor proliferation Open
Primary cilia play a pivotal role in cellular signaling and development and disruptions in ciliary form and/or function leads to human ciliopathies. Here, we examine the role of Ttc21b , a key component of the intraflagellar transport-A co…
View article: Sox10 is required for systemic initiation of bone mineralization
Sox10 is required for systemic initiation of bone mineralization Open
Heterozygous variants in SOX10 cause congenital syndromes affecting pigmentation, digestion, hearing, and neural development, primarily attributable to failed differentiation or loss of non-skeletal neural crest derivatives. We report here…
View article: Control of cranial ectomesenchyme fate by Nr2f nuclear receptors
Control of cranial ectomesenchyme fate by Nr2f nuclear receptors Open
Certain cranial neural crest cells are uniquely endowed with the ability to make skeletal cell types otherwise only derived from mesoderm. As these cells migrate into the pharyngeal arches, they downregulate neural crest specifier genes an…
View article: Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants
Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants Open
The primary cilium is a signaling center critical for proper embryonic development. Previous studies have demonstrated that mice lacking Ttc21b have impaired retrograde trafficking within the cilium and multiple organogenesis phenotypes, i…
View article: <i>Nubp2</i>is required for cranial neural crest survival in the mouse
<i>Nubp2</i>is required for cranial neural crest survival in the mouse Open
The N-ethyl-N-nitrosourea (ENU) forward genetic screen is a useful tool for the unbiased discovery of novel mechanisms regulating developmental processes. We recovered the dorothy mutation in such a screen designed to recover recessive mut…
View article: Relations Between Stream Chemistry, Fish Diversity, and Land Use in the Upper Little Miami Watershed
Relations Between Stream Chemistry, Fish Diversity, and Land Use in the Upper Little Miami Watershed Open
Streams are susceptible to numerous threats to their water quality and biodiversity. In southwest Ohio a major driver of these impacts is associated with current agricultural practices and associated legacy effects. These structural and ch…