David C. Poole
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View article: Silly walks: An urgent practical solution to the inactivity and obesity pandemics
Silly walks: An urgent practical solution to the inactivity and obesity pandemics Open
To assess whether the increased energy cost of silly walking (SW) could enhance physical activity, reduce obesity and extend health span, we retrospectively analysed data from 13 healthy adults (seven males, six females; age 22–71 years) w…
View article: Why Isn't Relational Learning Taking Over the World?
Why Isn't Relational Learning Taking Over the World? Open
Artificial intelligence seems to be taking over the world with systems that model pixels, words, and phonemes. The world is arguably made up, not of pixels, words, and phonemes but of entities (objects, things, including events) with prope…
View article: Effects of aging on the vasoconstrictor reactivity and potassium channel regulation of diaphragm arterioles from male and female Fischer-344 rats
Effects of aging on the vasoconstrictor reactivity and potassium channel regulation of diaphragm arterioles from male and female Fischer-344 rats Open
This investigation demonstrates that old age blunts both the myogenic response and potassium (K + )-induced vasoconstriction of diaphragm arterioles from male and female rats. The age-related decline in myogenic constriction was due, in pa…
View article: Physiology of nitrogen: A life or death matter
Physiology of nitrogen: A life or death matter Open
With each breath, four out of every five molecules we inspire are nitrogen (N 2 ), since this gas constitutes ∼80% of the atmospheric air that surrounds us. Despite its abundance and unlike molecular oxygen, N 2 has traditionally held less…
View article: Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction
Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction Open
Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation…
View article: Cooling-induced changes in intracellular hydrogen peroxide and gene expression in mouse skeletal muscle in vivo
Cooling-induced changes in intracellular hydrogen peroxide and gene expression in mouse skeletal muscle in vivo Open
This in vivo model successfully characterized the effects of cooling on cytosolic and mitochondrial [H 2 O 2 ] in mouse tibialis anterior skeletal muscle. Cooling decreased [H 2 O 2 ] down to ∼13°C, but the effect was reversed at still low…
View article: Increasing the health span: unique role for exercise
Increasing the health span: unique role for exercise Open
Health span, that period between birth and onset of major disease(s), when adequate physical and cognitive function permit those daily living activities essential to life quality, is lower in the United States than other developed countrie…
View article: Exercise promotes cognition and hippocampal mitochondrial complex II expression in female rats
Exercise promotes cognition and hippocampal mitochondrial complex II expression in female rats Open
Evidence supports that exercise defends against age‐associated declines in brain health and protects against neurodegenerative disease. To help understand the molecular basis for the neuroprotection, we examined the impact of training on m…
View article: Ageing impairs endothelium‐dependent vasodilatation and alters redox signalling in diaphragm arterioles from male and female Fischer‐344 rats
Ageing impairs endothelium‐dependent vasodilatation and alters redox signalling in diaphragm arterioles from male and female Fischer‐344 rats Open
Diaphragm hyperaemia and regional blood flow distribution are impaired with ageing, potentially consequent to altered vascular structure and/or diminished vasomotor function. Evidence from locomotory skeletal muscle suggests that age‐relat…
View article: Blue plaque review series: A.V. Hill, athletic records and the birth of exercise physiology
Blue plaque review series: A.V. Hill, athletic records and the birth of exercise physiology Open
One hundred years ago, A.V. Hill authored three manuscripts analysing athletic world records from a physiological perspective. That analysis, grounded in Hill's understanding of contemporary muscle bioenergetics, provides a fascinating ske…
View article: Tumor bearing in untreated breast cancer decreases exercise tolerance without lowering maximal oxygen uptake in rats
Tumor bearing in untreated breast cancer decreases exercise tolerance without lowering maximal oxygen uptake in rats Open
Breast cancer patients' maximal O2 uptake (V̇O2max) values average 60-80% of age-predicted values which is often attributed to adjuvant therapy rather than risk factors, comorbidities, or the tumor and associated factors (e.g., pro-inflamma…
View article: Skeletal and respiratory muscle blood flow redistribution during submaximal exercise in pulmonary hypertensive rats
Skeletal and respiratory muscle blood flow redistribution during submaximal exercise in pulmonary hypertensive rats Open
Pulmonary hypertension (PH) is a chronic, progressive disease characterized by pulmonary vascular remodelling, dyspnoea and exercise intolerance. Key facets of dyspnoea and exercise intolerance include skeletal and respiratory muscle contr…
View article: In vivo intracellular Ca<sup>2+</sup> profiles after eccentric rat muscle contractions: addressing the mechanistic bases for repeated bout protection
In vivo intracellular Ca<sup>2+</sup> profiles after eccentric rat muscle contractions: addressing the mechanistic bases for repeated bout protection Open
We demonstrated a reduced [Ca 2+ ] i profile with suppressed muscle damage after a repeated bout of ECC in vivo: the ECC-induced immediate [Ca 2+ ] i increase was suppressed and the persistence of increased [Ca 2+ ] i with localized accumu…
View article: Intracellular Ca2+ After Eccentric Muscle Contractions: Key Role for Ryanodine Receptors
Intracellular Ca2+ After Eccentric Muscle Contractions: Key Role for Ryanodine Receptors Open
Eccentric contractions (ECC) induce excessive intracellular calcium ion (Ca 2+ ) accumulation and muscle structural damage in localized regions of the muscle fibers. In this investigation, we present the novel hypothesis that the ryanodine…
View article: Death by nitrogen anoxia: On the integrated physiology of human execution
Death by nitrogen anoxia: On the integrated physiology of human execution Open
In opposition to any stated opinion that the death penalty and state execution are somehow humane, we demonstrate herein that the latest method, nitrogen anoxia, invoked by the state of Alabama is inherently inhumane. From a respiratory an…
View article: Further perspectives on measuring pulmonary oxygen uptake kinetics
Further perspectives on measuring pulmonary oxygen uptake kinetics Open
We thank Drs Francescato and Cettolo for stimulating further discussion on the 'Independent breath' (IND) algorithm for breath-by-breath gas exchange measurement. In Rossiter & Poole (2024) we mistakenly referred the reader to the work of …
View article: Measuring pulmonary oxygen uptake kinetics: Contemporary perspectives
Measuring pulmonary oxygen uptake kinetics: Contemporary perspectives Open
As championed by Brian J. Whipp, resolution of pulmonary oxygen uptake ( V ̇ O 2 ${\dot{V}}_{{{\mathrm{O}}}_{\mathrm{2}}}$ ) kinetics following exercise onset provides a unique and non-invasive window into muscle energetics, mitochondrial f…
View article: Pulmonary hypertension alters blood flow distribution and impairs the hyperemic response in the rat diaphragm
Pulmonary hypertension alters blood flow distribution and impairs the hyperemic response in the rat diaphragm Open
Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling, respiratory muscle and cardiac impairments, and exercise intolerance. Specifically, impaired gas exchange increases work of the diaphragm; however, compromised …
View article: Exercise intolerance with ageing: Major role for vascular dysfunction?
Exercise intolerance with ageing: Major role for vascular dysfunction? Open
Our health, happiness and, to a certain extent, our lifespan link inextricably – but not inexplicably – to our capacity for exercise and physical activity. Hippocrates opined 'If we could give every individual the right amount of nourishme…
View article: Assessing cardiorespiratory fitness relative to sex improves surgical risk stratification
Assessing cardiorespiratory fitness relative to sex improves surgical risk stratification Open
Background To what extent sex‐related differences in cardiorespiratory fitness (CRF) impact postoperative patient mortality and corresponding implications for surgical risk stratification remains to be established. Methods To examine this,…
View article: Effects of comorbid type II diabetes mellitus and heart failure on rat hindlimb and respiratory muscle blood flow during treadmill exercise
Effects of comorbid type II diabetes mellitus and heart failure on rat hindlimb and respiratory muscle blood flow during treadmill exercise Open
Herein, we demonstrate that rats comorbid with heart failure with reduced ejection fraction (HF-rEF) and type II diabetes mellitus (T2DM) have a higher hindlimb and respiratory muscle blood flow during submaximal treadmill running (20 m·mi…
View article: ‘Fatigue makes cowards of us all’
‘Fatigue makes cowards of us all’ Open
Fatigue makes cowards of us all. Whether it is the physical performance of soldiers on the battlefield, as for Lt. General George S. Patton Jr (1947), athletes on the American football field, as for legendary Green Bay Packers’ coach Vince…