David A. Power
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View article: Plasma total and donor-derived cell-free DNA predict survival in kidney transplant recipients
Plasma total and donor-derived cell-free DNA predict survival in kidney transplant recipients Open
Introduction Studies evaluating cell-free DNA (cfDNA) in kidney allograft dysfunction have primarily focused on detection of rejection by donor-derived cfDNA (ddcfDNA). The utility of ddcfDNA as a marker of longer-term outcomes has not bee…
View article: Glycolytic control proteins in urinary extracellular vesicles are elevated during kidney transplant T cell-mediated rejection
Glycolytic control proteins in urinary extracellular vesicles are elevated during kidney transplant T cell-mediated rejection Open
View article: The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury
The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury Open
Acute kidney injury (AKI) disrupts energy metabolism. Targeting metabolism through AMP-activated protein kinase (AMPK) may alleviate AKI. ATX-304, a pan-AMPK activator, was evaluated in C57Bl/6 mice and tubular epithelial cell (TEC) cultur…
View article: 2212MO Major secondary outcomes in the multicentre noninferiority randomised trial IoN: Is ablative radioiodine necessary for low-risk differentiated thyroid cancer patients?
2212MO Major secondary outcomes in the multicentre noninferiority randomised trial IoN: Is ablative radioiodine necessary for low-risk differentiated thyroid cancer patients? Open
View article: Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia
Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia Open
ENaC expression is upregulated in UEV of pre-eclamptic subjects but was not associated with changes in NEDD4L.
View article: PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages
PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages Open
View article: Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney
Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney Open
The anti-fibrotic effect of metformin has been widely demonstrated. Fibrosis in the kidney after injury is associated with reduced expression of genes involved in both fatty acid and glycolytic energy metabolism. We have previously reporte…
View article: Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin
Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin Open
View article: Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-sensitive Pathways
Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-sensitive Pathways Open
Excessive production of renal reactive oxygen species (ROS) play a major role in diabetic kidney disease (DKD). Here, we provide key novel findings demonstrating the predominant pathological role of the prooxidant enzyme NADPH oxidase-NOX5…
View article: Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-sensitive Pathways
Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-sensitive Pathways Open
Excessive production of renal reactive oxygen species (ROS) play a major role in diabetic kidney disease (DKD). Here, we provide key novel findings demonstrating the predominant pathological role of the prooxidant enzyme NADPH oxidase-NOX5…
View article: Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways
Independent of Renox, NOX5 Promotes Renal Inflammation and Fibrosis in Diabetes by Activating ROS-Sensitive Pathways Open
Excessive production of renal reactive oxygen species (ROS) plays a major role in diabetic kidney disease (DKD). Here, we provide key findings demonstrating the predominant pathological role of the pro-oxidant enzyme NADPH oxidase 5 (NOX5)…
View article: 561: Biofilm phenotyping of patients chronically infected with Pseudomonas aeruginosa reveals a novel, putative biomarker for biofilm infection in cystic fibrosis
561: Biofilm phenotyping of patients chronically infected with Pseudomonas aeruginosa reveals a novel, putative biomarker for biofilm infection in cystic fibrosis Open
View article: Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis
Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis Open
View article: AB042. Evaluation of the influence of wall shear stress features on endothelial cell phenotypes
AB042. Evaluation of the influence of wall shear stress features on endothelial cell phenotypes Open
Background: Patency rates for arteriovenous fistulae (AVF) range between 40-50% at 4 years with neointimal hyperplasia of the venous limb being a significant determining factor. The wall shear stress (WSS) is a potent stimulus of neointima…
View article: AB038. Assessing the quality of online information for patients with carotid disease—a 5-year follow up
AB038. Assessing the quality of online information for patients with carotid disease—a 5-year follow up Open
Background: The availability of medical information has increased in recent decades. This does not necessarily equate with readable information. The aim of this study is to assess the readability of online available information, 5 years on…
View article: Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility
Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility Open
The sequelae of diabetes include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediated renal injury associated with a disruption in mitochondrial metabolic agility, inflammation, and fibrosis. W…
View article: SUN-148 THREE DIMENSIONAL GLOMERULAR RECONSTRUCTION: A NOVEL APPROACH TO EVALUATE RENAL MICROANATOMY IN DIABETIC KIDNEY DISEASE
SUN-148 THREE DIMENSIONAL GLOMERULAR RECONSTRUCTION: A NOVEL APPROACH TO EVALUATE RENAL MICROANATOMY IN DIABETIC KIDNEY DISEASE Open
Mesangial metrics reflect glomerular filtration surface area in diabetes. The point-sampled intercept (PSI) method is the conventional method to calculate these parameters. However, this is time consuming and subject to underestimation. We…
View article: Absence of the β1 subunit of <scp>AMP</scp>‐activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes
Absence of the β1 subunit of <span>AMP</span>‐activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes Open
Summary Activation of the heterotrimeric energy‐sensing kinase AMP ‐activated protein kinase ( AMPK ) has been reported to improve experimental diabetic kidney disease. We examined the effect of type 1 diabetes in wild‐type ( WT ) mice and…
View article: Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia
Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia Open
View article: Three Dimensional Glomerular Reconstruction: A Novel Approach to Evaluate Renal Microanatomy in Diabetic Kidney Disease
Three Dimensional Glomerular Reconstruction: A Novel Approach to Evaluate Renal Microanatomy in Diabetic Kidney Disease Open
View article: Comparison of Clinic-Pathological, Molecular Features and PD-L1 Status in a Series of Non-small Cell Lung Cancers: Are Real Life Data Similar to Clinical Trials results?
Comparison of Clinic-Pathological, Molecular Features and PD-L1 Status in a Series of Non-small Cell Lung Cancers: Are Real Life Data Similar to Clinical Trials results? Open
Objective: Immunotherapy is a promising treatment option for a subset of lung cancers as it utilizes the host’s own immune system to attack tumors cells. Selection of patients who are likely to respond to immunotherapy is based on PD-L1 ex…
View article: Malignant Hypertension Causing a Pulmonary-Renal Syndrome
Malignant Hypertension Causing a Pulmonary-Renal Syndrome Open
Background. Pulmonary-renal syndrome is characterised by acute kidney injury, haematuria, and haemoptysis and is a well-recognised presentation of diseases such as ANCA vasculitis that require urgent immunosuppression. Case Presentation. A…
View article: Diagnostic application of kidney allograft-derived absolute cell-free DNA levels during transplant dysfunction
Diagnostic application of kidney allograft-derived absolute cell-free DNA levels during transplant dysfunction Open
Graft-derived cell-free DNA (donor-derived cell-free DNA) is an emerging marker of kidney allograft injury. Studies examining the clinical validity of this biomarker have previously used the graft fraction, or proportion of total cell-free…
View article: Pre-eclampsia is associated with altered expression of the renal sodium transporters NKCC2, NCC and ENaC in urinary extracellular vesicles
Pre-eclampsia is associated with altered expression of the renal sodium transporters NKCC2, NCC and ENaC in urinary extracellular vesicles Open
Pre-eclampsia is a hypertensive disorder of pregnancy characterised by hypertension and sodium retention by the kidneys. To identify changes in sodium uptake proteins in the tubules of the distal nephron, we studied their expression in uri…
View article: Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin
Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin Open
Background Expression of genes regulating fatty acid metabolism is reduced in tubular epithelial cells from kidneys with tubulointerstitial fibrosis (TIF), thus decreasing the energy produced by fatty acid oxidation (FAO). Acetyl-CoA carbo…
View article: AB035. 242. Measuring what matters—a 5-year study of factors predicting arteriovenous fistulae outcomes
AB035. 242. Measuring what matters—a 5-year study of factors predicting arteriovenous fistulae outcomes Open
Background: Arteriovenous fistulas (AVF) are the preferred method of access for patients undergoing haemodialysis. Over half of AVFs are non-functioning 4 years post-formation, however despite the use of vascular imaging prior to fistula f…
View article: Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells
Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells Open
View article: Evaluation of 18F-fluorothymidine positron emission tomography ([18F]FLT-PET/CT) methodology in assessing early response to chemotherapy in patients with gastro-oesophageal cancer
Evaluation of 18F-fluorothymidine positron emission tomography ([18F]FLT-PET/CT) methodology in assessing early response to chemotherapy in patients with gastro-oesophageal cancer Open
View article: Safety profile of nivolumab (NIVO) and ipilimumab (IPI) combination therapy in patients (pts) with advanced melanoma (MEL)
Safety profile of nivolumab (NIVO) and ipilimumab (IPI) combination therapy in patients (pts) with advanced melanoma (MEL) Open
View article: Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis
Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis Open
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein with dual roles in redox signaling and programmed cell death. Deficiency in AIF is known to result in defective oxidative phosphorylation (OXPHOS), via loss of complex I activ…