David Price
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View article: A 21-Practice Evaluation of an Asthma and COPD Quality Improvement Program
A 21-Practice Evaluation of an Asthma and COPD Quality Improvement Program Open
Our findings support the potential for the ACAER asthma and COPD program to drive treatment change and improve long-term outcomes in high-risk patients in primary care settings.
View article: Correction to: The Association Between Short-Acting β2-Agonist Over-Prescription, and Patient-Reported Acquisition and Use on Asthma Control and Exacerbations: Data from Australia
Correction to: The Association Between Short-Acting β2-Agonist Over-Prescription, and Patient-Reported Acquisition and Use on Asthma Control and Exacerbations: Data from Australia Open
View article: Reply to Liu <i>et al.</i>, Zhou <i>et al.</i>, and Dong <i>et al.</i>
Reply to Liu <i>et al.</i>, Zhou <i>et al.</i>, and Dong <i>et al.</i> Open
International audience
View article: Changes in use and utilisation patterns of drugs with reported shortages between 2010 and 2024 in Europe and North America: a network cohort study
Changes in use and utilisation patterns of drugs with reported shortages between 2010 and 2024 in Europe and North America: a network cohort study Open
Innovative Medicines Initiative 2 Joint Undertaking.
View article: Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach
Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach Open
T2-targeting biologics have utility in the management of asthma with low T2 involvement, but more effective therapies are needed. Further research is warranted to identify specific pathogenic pathways at the lower end of the T2 spectrum th…
View article: Expert Perspectives on Next Generation Health Guidelines: How to Integrate RWE in EBM
Expert Perspectives on Next Generation Health Guidelines: How to Integrate RWE in EBM Open
Integrating real-world evidence (RWE) into evidence-based medicine (EBM) enhances healthcare decision-making. RWE provides insights into the real-world effectiveness and safety of therapies and health technologies, filling gaps that clinic…
View article: Disease Trajectory and Treatment Escalation in Asthma: A Retrospective Analysis of Data From the Optimum Patient Care Research Database (OPCRD)
Disease Trajectory and Treatment Escalation in Asthma: A Retrospective Analysis of Data From the Optimum Patient Care Research Database (OPCRD) Open
Treatment escalation is associated with mood disorder and asthma exacerbations. Obesity is highly prevalent in patients with asthma before treatment escalation. A symptom-based treatment approach potentially exposes patients to inappropria…
View article: Effect of budesonide/glycopyrronium/formoterol fumarate dihydrate on cardiopulmonary outcomes in COPD: rationale and design of the THARROS trial
Effect of budesonide/glycopyrronium/formoterol fumarate dihydrate on cardiopulmonary outcomes in COPD: rationale and design of the THARROS trial Open
Background Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are leading causes of death with overlapping and syndemic pathophysiological interactions. Inhaled triple therapies containing inhaled corticosteroids…
View article: Correction: Update on Psychiatry Residency Training in Personality Disorders: Becoming a Good Psychiatrist Through Becoming “Good Enough” at Treating Borderline and Narcissistic Personality Disorders
Correction: Update on Psychiatry Residency Training in Personality Disorders: Becoming a Good Psychiatrist Through Becoming “Good Enough” at Treating Borderline and Narcissistic Personality Disorders Open
View article: Association of Frequent Short-Acting Beta-Agonist Inhaler Prescriptions with Acute Cardiovascular Events
Association of Frequent Short-Acting Beta-Agonist Inhaler Prescriptions with Acute Cardiovascular Events Open
Frequent SABA usage appears to be associated with an increased risk of ACE even in patients not having oral corticosteroids for exacerbations of asthma or COPD. The risks of frequent SABA usage need both further research and clinical consi…
View article: Burden of Oral Corticosteroid Use in Severe Asthma: Challenges and Opportunities
Burden of Oral Corticosteroid Use in Severe Asthma: Challenges and Opportunities Open
Over the past 70 years, oral corticosteroids (OCS) have played an important role in the management of acute and chronic asthma; however, their use is associated with an increased incidence of adverse events, chronic diseases such as osteop…
View article: Prediction Pathway for Severe Asthma Exacerbations
Prediction Pathway for Severe Asthma Exacerbations Open
This study identified an essential prediction pathway of severe exacerbation, which involves the influence of chronic rhinosinusitis on the immediate predictors of risk transition from current to future severe asthma exacerbations. Macroli…
View article: Patterns of care in the management of high-risk COPD in Australia (2015–2019): an observational study for the CONQUEST quality improvement program
Patterns of care in the management of high-risk COPD in Australia (2015–2019): an observational study for the CONQUEST quality improvement program Open
This study was conducted by Optimum Patient Care Australia Pty Ltd (OPCA) and was partially funded by OPCA and AstraZeneca Pty Ltd. No funding was received by the Observational & Pragmatic Research Institute Pte Ltd (OPRI) for its contribu…
View article: Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT
Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT Open
Background Observational studies of people with chronic obstructive pulmonary disease using beta-blockers for cardiovascular disease indicate that beta-blocker use is associated with reduced risk of chronic obstructive pulmonary disease ex…
View article: The Real-World Impact of Glucagon-Like Peptide 1 Receptor Agonists on Asthma Control in People with High-Risk Asthma and Obesity
The Real-World Impact of Glucagon-Like Peptide 1 Receptor Agonists on Asthma Control in People with High-Risk Asthma and Obesity Open
View article: CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment
CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment Open
Background: Prevention of lung attacks (LAs)/exacerbation is an important treatment goal in both asthma and chronic obstructive pulmonary disease (COPD). However, LAs are often not registered as such in medical records. Objectives: Develop…
View article: Real-World Biologic Use Patterns in Severe Asthma, 2015–2021: The CLEAR Study
Real-World Biologic Use Patterns in Severe Asthma, 2015–2021: The CLEAR Study Open
Switching or stopping biologic therapy was associated with worse clinical outcomes than continuing the initial therapy.
View article: Predicting Risk of Morbidities Associated with Oral Corticosteroid Prescription for Asthma
Predicting Risk of Morbidities Associated with Oral Corticosteroid Prescription for Asthma Open
OCS exposure in this primary care asthma population usually continued longitudinally. Our models predict increased risk of multiple morbidities with higher projected OCS exposure. These findings support early initiation of strategies to mi…
View article: Identification and management of cardiopulmonary risk in patients with chronic obstructive pulmonary disease: a multidisciplinary consensus and modified Delphi study
Identification and management of cardiopulmonary risk in patients with chronic obstructive pulmonary disease: a multidisciplinary consensus and modified Delphi study Open
Aims Cardiovascular disease is a common comorbidity in chronic obstructive pulmonary disease. Yet, cardiovascular disease and risk are underdiagnosed in chronic obstructive pulmonary disease and are often undertreated, increasing the risk …
View article: Increasing Prevalence of Syphilis: Oral Manifestations, Diagnosis and Management
Increasing Prevalence of Syphilis: Oral Manifestations, Diagnosis and Management Open
Introduction Cases of syphilis are increasing, with 9513 cases diagnosed in England in 2023, the highest annual number since 1948. Oral healthcare professionals should therefore be aware of how oral syphilis presents, the differential diag…
View article: International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update
International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update Open
The International Severe Asthma Registry (ISAR) was established in 2017 to advance the understanding of severe asthma and its management, thereby improving patient care worldwide. As the first global registry for adults with severe asthma,…
View article: Re “Inhaled Corticosteroid Particle Size and Risk of Hospitalization Rue to Exacerbations and All-Cause Mortality in Patients With Chronic Obstructive Respiratory Disease. A Nationwide Cohort Study”. Heerfordt et al [Letter]
Re “Inhaled Corticosteroid Particle Size and Risk of Hospitalization Rue to Exacerbations and All-Cause Mortality in Patients With Chronic Obstructive Respiratory Disease. A Nationwide Cohort Study”. Heerfordt et al [Letter] Open
Peer reviewed
View article: Using routine primary care data in research: (in)efficient case studies and perspectives from the Asthma UK Centre for Applied Research
Using routine primary care data in research: (in)efficient case studies and perspectives from the Asthma UK Centre for Applied Research Open
Aim We aimed to identify enablers and barriers of using primary care routine data for healthcare research, to formulate recommendations for improving efficiency in knowledge discovery. Background Data recorded routinely in primary care can…
View article: Lung Cancer in Interstitial Lung Disease: A Matched Case-Control and Cohort Analysis
Lung Cancer in Interstitial Lung Disease: A Matched Case-Control and Cohort Analysis Open
View article: Pragmatic Evaluation of an Improvement Program for People Living With Modifiable High-Risk COPD Versus Usual Care: Protocol for the Cluster Randomized PREVAIL Trial
Pragmatic Evaluation of an Improvement Program for People Living With Modifiable High-Risk COPD Versus Usual Care: Protocol for the Cluster Randomized PREVAIL Trial Open
UK trial: ISRCTN15819828; US trial: NCT05306743.
View article: The Importance of Turnaround and Variant Doubling Times for the Early Detection of Novel and Emerging Viruses using Genomic Surveillance
The Importance of Turnaround and Variant Doubling Times for the Early Detection of Novel and Emerging Viruses using Genomic Surveillance Open
View article: Practical strategies for achieving system change in the US: lessons and insights from the CONQUEST quality improvement programme
Practical strategies for achieving system change in the US: lessons and insights from the CONQUEST quality improvement programme Open
Background: Quality improvement programmes (QIPs) are designed to enhance patient outcomes by systematically introducing evidence-based clinical practices. The CONQUEST QIP focuses on improving the identification and management of patients…
View article: Reply to: Is there a kindling effect in COPD exacerbations?
Reply to: Is there a kindling effect in COPD exacerbations? Open
Real world studies have shown that over half of the patients having an exacerbation will not have one in the next year, suggesting that the majority of patients are not subject to a “kindling effect” https://bit.ly/3O016tT
View article: Preserved Ratio Impaired Spirometry in US Primary Care Patients Diagnosed with Chronic Obstructive Pulmonary Disease
Preserved Ratio Impaired Spirometry in US Primary Care Patients Diagnosed with Chronic Obstructive Pulmonary Disease Open
One in four primary care patients with clinically diagnosed COPD in a large US registry fulfil the spirometric definition of PRISm rather than COPD, but suffers from emphysema in CT and significant respiratory symptoms.
View article: Use and acceptability of an asthma diagnosis clinical decision support system for primary care clinicians: an observational mixed methods study
Use and acceptability of an asthma diagnosis clinical decision support system for primary care clinicians: an observational mixed methods study Open
There is uncertainty about how best to diagnose asthma, especially in primary care where mis-diagnosis is common. To address this, we developed a clinical decision support system (CDSS) for asthma diagnosis in children and young people (ag…