David Proud
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View article: WS12.04 An “expanding area” of interest – the effect of elexacaftor/tezacaftor/ivacaftor (ETI) therapy on body image and weight
WS12.04 An “expanding area” of interest – the effect of elexacaftor/tezacaftor/ivacaftor (ETI) therapy on body image and weight Open
View article: WS18.06 The impact of cytomegalovirus on airway epithelial gene expression
WS18.06 The impact of cytomegalovirus on airway epithelial gene expression Open
View article: Inhibition of TGFβ-induced Fibroblast to Myofibroblast Transition by Conditioned Medium From Human Rhinovirus-infected Airway Epithelial Cells is Mediated by Prostaglandin E2
Inhibition of TGFβ-induced Fibroblast to Myofibroblast Transition by Conditioned Medium From Human Rhinovirus-infected Airway Epithelial Cells is Mediated by Prostaglandin E2 Open
Background Airway remodeling, including increased deposition of extracellular matrix proteins, is a hallmark of asthma. Myofibroblasts, derived via fibroblast to myofibroblast transition (FMT), play an important role in this increased depo…
View article: Inhibition of TGFb-induced Fibroblast to Myofibroblast Transition by Conditioned Medium from Human Rhinovirus-infected Airway Epithelial Cells is Mediated by Prostaglandin E2
Inhibition of TGFb-induced Fibroblast to Myofibroblast Transition by Conditioned Medium from Human Rhinovirus-infected Airway Epithelial Cells is Mediated by Prostaglandin E2 Open
Background: Airway remodeling, including increased deposition of extracellular matrix proteins, is a hallmark of asthma. Myofibroblasts, derived via fibroblast to myofibroblast transition (FMT), play an important role in this increased dep…
View article: Epithelial Barrier Dysfunction Is Mediated by Lysophosphatidic Acid and Associated Cytokines
Epithelial Barrier Dysfunction Is Mediated by Lysophosphatidic Acid and Associated Cytokines Open
Background: Acute allergen exposure is associated with transient epithelial barrier loss in the asthmatic airways, allowing passage of intraluminal allergens, particles, and cytokines to create a positive feedforward loop of inflammation.C…
View article: Multi-Omics Reveal Rhinovirus Strain-Specific Metabolic Signatures in Highly Differentiated Human Airway Epithelial Cells
Multi-Omics Reveal Rhinovirus Strain-Specific Metabolic Signatures in Highly Differentiated Human Airway Epithelial Cells Open
View article: Editorial: The Response of Mucosal Epithelial Cells to Infections
Editorial: The Response of Mucosal Epithelial Cells to Infections Open
EDITORIAL article Front. Cell. Infect. Microbiol., 16 November 2020Sec. Microbes and Innate Immunity https://doi.org/10.3389/fcimb.2020.602312
View article: Publisher Correction: IGF1R is an entry receptor for respiratory syncytial virus
Publisher Correction: IGF1R is an entry receptor for respiratory syncytial virus Open
View article: P281 Body composition in adults with cystic fibrosis – are measurements taken using single frequency and multifrequency devices interchangeable?
P281 Body composition in adults with cystic fibrosis – are measurements taken using single frequency and multifrequency devices interchangeable? Open
View article: P211 Real-world experience of lumacaftor/ivacaftor combination in Welsh cystic fibrosis patients homozygous for the F508del CFTR mutation with severe lung disease
P211 Real-world experience of lumacaftor/ivacaftor combination in Welsh cystic fibrosis patients homozygous for the F508del CFTR mutation with severe lung disease Open
View article: P272 High dose vitamin D supplementation: the patient knows best
P272 High dose vitamin D supplementation: the patient knows best Open
View article: Human Rhinovirus Infection of Primary Bronchial Epithelial Cells Upregulates Prostaglandin E2 Production That Attenuates Transforming Growth Factor Beta-1-Induced Fibroblast-to-Myofibroblast Transition
Human Rhinovirus Infection of Primary Bronchial Epithelial Cells Upregulates Prostaglandin E2 Production That Attenuates Transforming Growth Factor Beta-1-Induced Fibroblast-to-Myofibroblast Transition Open
View article: Rhinovirus C Infection Activates Cytoskeletal Signaling and Results in Barrier Loss in Highly Differentiated Airway Epithelial Cells
Rhinovirus C Infection Activates Cytoskeletal Signaling and Results in Barrier Loss in Highly Differentiated Airway Epithelial Cells Open
View article: Regulation of the Antiviral Protein Viperin in Human Airway Epithelial Cells Infected with Human Rhinovirus
Regulation of the Antiviral Protein Viperin in Human Airway Epithelial Cells Infected with Human Rhinovirus Open
View article: List of SYBR RT-qPCR primer sequences.
List of SYBR RT-qPCR primer sequences. Open
View article: Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells
Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells Open
Type III interferons (IFN-lambdas(λ)) are important cytokines that inhibit viruses and modulate immune responses by acting through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, the primary antiviral function of IFN-λs has bee…
View article: Performance Characteristics of Spirometry With Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis
Performance Characteristics of Spirometry With Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis Open
View article: Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells
Rhinovirus Induces Basolateral Release of IL-17C in Highly Differentiated Airway Epithelial Cells Open
Human rhinovirus (HRV) is a major trigger of acute exacerbations of both asthma and chronic obstructive pulmonary disease. The airway epithelium is the primary site of HRV infection, and responds by releasing proinflammatory and antimicrob…
View article: P206 Putting some backbone into managing low vitamin D
P206 Putting some backbone into managing low vitamin D Open
View article: P192 To be or not to be (happy): fat is the question?
P192 To be or not to be (happy): fat is the question? Open
View article: Tumor necrosis factor<i>α</i>decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription
Tumor necrosis factor<i>α</i>decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription Open
Inflammatory diseases of the gut are associated with altered electrolyte and water transport, leading to the development of diarrhea. Epithelially expressed aquaporins (AQPs) are downregulated in inflammation, although the mechanisms invol…
View article: Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations: A randomized controlled study
Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations: A randomized controlled study Open
View article: AllerGen’s 8th research conference
AllerGen’s 8th research conference Open
View article: TLR2 Activation Limits Rhinovirus-Stimulated CXCL-10 by Attenuating IRAK-1–Dependent IL-33 Receptor Signaling in Human Bronchial Epithelial Cells
TLR2 Activation Limits Rhinovirus-Stimulated CXCL-10 by Attenuating IRAK-1–Dependent IL-33 Receptor Signaling in Human Bronchial Epithelial Cells Open
Airway epithelial cells are the major target for rhinovirus (RV) infection and express proinflammatory chemokines and antiviral cytokines that play a role in innate immunity. Previously, we demonstrated that RV interaction with TLR2 causes…
View article: WS10.6 Are cystic fibrosis patients frail? Is 50 the new 80?
WS10.6 Are cystic fibrosis patients frail? Is 50 the new 80? Open
View article: 191 Test–retest reliability of bioelectrical impedance and hand grip strength over 1 year in adult patients with cystic fibrosis
191 Test–retest reliability of bioelectrical impedance and hand grip strength over 1 year in adult patients with cystic fibrosis Open
View article: Additional file 3: of Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection
Additional file 3: of Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection Open
This excel file contains the list of differentially expressed genes identified in HRV-induced HBE cells transfected with IRF7-siRNA #1 versus the all-star control siRNA. (XLSX 77Â kb)
View article: Additional file 4: of Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection
Additional file 4: of Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection Open
This excel file contains the list of biological pathways that were decreased in HRV-induced HBE cells transfected with IRF7-siRNA#1 versus the all-star control siRNA. (XLSX 13Â kb)
View article: Additional file 2: of Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection
Additional file 2: of Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection Open
This excel file contains the list of biological pathways that were upregulated by HRV in HBE cells transfected with the all-star control siRNA. (XLSX 23Â kb)
View article: Cystic Fibrosis: Detecting frailty in an outpatient clinic
Cystic Fibrosis: Detecting frailty in an outpatient clinic Open